Preparation and Characterization of Vitamin-D Incorporated Marshmallow

This project looks at a novel way to enhance the sensory experience of vitamin D ingestion by incorporating it into marshmallows. This investigation used a human panel taste test with twelve individuals, an index of swelling, and a stability evaluation. Samples of vitamin D infused marshmallows were prepared and given to participants in the human panel taste test, which evaluated mouthfeel and flavor. By analyzing dissolving behavior, the swelling index test revealed unexpected erosion. In addition, a temperature threshold for storage conditions was found through a temperature sensitivity test. All of these techniques assessed the feasibility and palatability of vitamin D supplementation with marshmallow flavor, offering insights into both the possible advantages and difficulties. The marshmallow infusion technique effectively covered up the disagreeable taste of vitamin D pills, leading to reviews that were overwhelmingly favorable (“Moderate Sweet”) and that indicated a pleasant mouthfeel. During the swelling index test, it showed erosion behavior, suggesting a certain kind of dissolution that is advantageous for nutritional absorption. Furthermore, the study discovered a temperature sensitivity threshold, highlighting how crucial proper storage conditions are.

Coupling ferromagnetic ordering electron transfer channels and surface reconstructed active species for spintronic electrocatalysis of water oxidation

Sluggish reaction kinetics of oxygen evolution reaction(OER), resulting from multistep proton-coupled electron transfer and spin constriction, limits overall efficiency for most reported catalysts. Herein, using modeled ZnFe_(2-x)Ni_xO_(4)(0 ≤ x ≤ 0.4) spinel oxides, we aim to develop better OER electrocatalyst through combining the construction of ferromagnetic(FM) ordering channels and generation of highly active reconstructed species. The number of symmetry-breaking Fe–O–Ni structure links to the formation of FM ordering electron transfer channels. Meanwhile, as the number of Ni^(3+)increases, more ligand holes are formed, beneficial for redirecting surface reconstruction. The electro-activated ZnFe_(1.6)Ni_(0.4)O_(4) shows the highest specific activity, which is 13 and 2.5 times higher than that of ZnFe_(2)O_(4) and unactivated ZnFe_(1.6)Ni_(0.4)O_(4), and even superior to the benchmark IrO_(2) under the overpotential of 350 mV. Applying external magnetic field can make electron spin more aligned, and the activity can be further improved to 39 times of ZnFe_(2)O_(4). We propose that intriguing FM exchange-field interaction at FM/paramagnetic interfaces can penetrate FM ordering channels into reconstructed oxyhydroxide layers, thereby activating oxyhydroxide layers as spin-filter to accelerate spin-selective electron transfer. This work provides a new guideline to develop highly efficient spintronic catalysts for water oxidation and other spin-forbidden reactions.

Recent Advances in the Comprehension and Regulation of Lattice Oxygen Oxidation Mechanism in Oxygen Evolution Reaction

Water electrolysis,a process for producing green hydrogen from renewable energy,plays a crucial role in the transition toward a sustainable energy landscape and the realization of the hydrogen economy.Oxygen evolution reaction(OER)is a critical step in water electrolysis and is often limited by its slow kinetics.Two main mechanisms,namely the adsorbate evolution mechanism(AEM)and lattice oxygen oxidation mechanism(LOM),are commonly considered in the context of OER.However,designing efficient catalysts based on either the AEM or the LOM remains a topic of debate,and there is no consensus on whether activity and stability are directly related to a certain mechanism.Considering the above,we discuss the characteristics,advantages,and disadvantages of AEM and LOM.Additionally,we provide insights on leveraging the LOM to develop highly active and stable OER catalysts in future.For instance,it is essential to accurately differentiate between reversible and irreversible lattice oxygen redox reactions to elucidate the LOM.Furthermore,we discuss strategies for effectively activating lattice oxygen to achieve controllable steady-state exchange between lattice oxygen and an electrolyte(OH^(-)or H_(2)O).Additionally,we discuss the use of in situ characterization techniques and theoretical calculations as promising avenues for further elucidating the LOM.

Dabigatran in cardiovascular disease management:A comprehensive review

Dabigatran,a direct thrombin inhibitor,has robust data for the treatment of deep venous thrombosis and pulmonary embolism,stroke prevention in non-valvular atrial fibrillation,and the prophylaxis of venous thromboembolism(VTE)after knee and hip replacement.Recent studies have evaluated dabigatran to determine its safety and efficacy in such conditions as VTE in malignancy,coronary artery disease,mechanical and bioprosthetic valves,and antiphospholipid syndrome.This article provides a comprehensive review on the role of dabigatran in various cardiovascular diseases.

Using IoT Innovation and Efficiency in Agriculture Monitoring System

Agriculture is undoubtedly a leading field for livelihoods in China.As the population increases,it is necessary to increase agricultural productivity.By capturing the support and the increment in production on farms,the need for freshwater used for irrigation increases too.Presently,agriculture accounts for 80% of overall water uptake in China.Unexpected overflow of water carelessly leads to waste of water.Therefore we created a programmed plant irrigation system with Arduino that mechanically supplies water to the plants and keeps it updated by transferring the message to user.Plant irrigation system employs the soil moisture sensor which controls a degree of moisture in the soil.If the humidity degree is lower,Arduino activates a pump of water to supply water to the system.The pump of water stops by design when the organism detects sufficient moisture in the ground.Each time the system is switched off or on,an electronic messaging is conveyed to the end-user through the IoT unit,informing the position of the soil moisture and the pump of water.A spray motor and the pump of water are grounded on the crane concept.Widely,this system is applicable for in small fields,gardens farms,etc.This design is entirely programmed and needed no human involvement.Furthermore,transmission of the sensor readings send through a Thing speak frequency to produce graphic elements for better inquiry.This study gathers the ideas of IoT(Internet of Things)with some engineering tools like machinery,artificial intelligence and use of sensors in an efficient way to respond current needs and extraction of resources by availing scientific methods and procedures that work on inputs.Moreover,this study further defines the engineering works that have been part of this field,but it requires more efficiency and reduction of energy as well as costs by adding more contribution of IoT in the field of agriculture engineering.

Additional responsibility for physicians caring for cardiac patients: Insight from a case series

Resuscitation measures performed at the scene of the event have the ultimate impact on the outcome of a cardiac arrest. We analysed six case histories of those sudden cardiac arrest patients who were revived in the field and were subsequently admitted to the intensive care unit during a six-month period. All were known cardiac patients and were under the care of healthcare providers. Four of those were discharged home from the hospital and did not suffer any residual damage where as one died of multi-organ failure and the other was declared brain dead. The outcome was good in patients who received early intervention in the form of basic life support. The family members of non-survivors witnessed the cardiac arrest at home but were not familiar with the concept or procedures of basic life support. We propose that physicians who care for cardiac patients should undertake the task of increasing family member awareness and knowledge in the techniques of basic life support.

In silico analysis of a disease-causing mutation in PCDH15 gene in a consanguineous Pakistani family with Usher phenotype

AIM： To map Usher phenotype in a consanguineous Pakistani family and identify disease-associated mutation in a causative gene to establish phenotype-genotype correlation.· METHODS： A consanguineous Pakistani family in which Usher phenotype was segregating as an autosomal recessive trait was ascertained. On the basis of results of clinical investigations of affected members of this family disease was diagnosed as Usher syndrome（USH）. To identify the locus responsible for the Usher phenotype in this family, genomic DNA from blood sample of each individual was genotyped using microsatellite Short Tandem Repeat（STR） markers for the known Usher syndrome loci. Then direct sequencing was performed to find out disease associated mutations in the candidate gene.· RESULTS： By genetic linkage analysis, the USH phenotype of this family was mapped to PCDH15 locus on chromosome 10q21.1. Three different point mutations in exon 11 of PCDH15 were identified and one of them,c.1304AC was found to be segregating with the disease phenotype in Pakistani family with Usher phenotype.This, c.1304 A C transversion mutation predicts an amino-acid substitution of aspartic acid with an alanine at residue number 435（p.D435A） of its protein product.Moreover, in silico analysis revealed conservation of aspartic acid at position 435 and predicated this change as pathogenic.·CONCLUSION：Theidentificationofc.1304ACpathogenic mutation in PCDH15 gene and its association with Usher syndrome in a consanguineous Pakistani family is thefirst example of a missense mutation of PCDH15 causing USH1 phenotype. In previous reports, it was hypothesized that severe mutations such as truncated protein of PCDH15 led to the Usher I phenotype and that missense variants are mainly responsible for non-syndromic hearing impairment.

Plant-soil feedback during biological invasions:effect of litter decomposition from an invasive plant(Sphagneticola trilobata)on its native congener(S.calendulacea)

Plant invasions can affect soil properties in the invaded habitat by altering the biotic and abiotic nature of soils through positive or negative plant–soil feedback.Litter decomposition from many invasive species enhanced soil nutrients,thereby decreasing native plant diversity and leading to further plant invasions.Here,we examined the impact of litter decomposition from an invasive plant(Sphagneticola trilobata)in a range of soils at varying depths on growth and physiology of its native congener(Sphagneticola calendulacea).We added litter from S.trilobata to each soil type at different depths(0,2,4 and 6 cm).Plants of S.calendulacea were grown in each treatment,and morphological and physiological parameters were measured at the end of the growing period.All soils treated with litter displayed increases in soil nutrients at depths of 2 and 4 cm;while most growth traits,leaf chlorophyll and leaf nitrogen of S.calendulacea decreased at the same soil depths.Therefore,litter decomposition from invasive S.trilobata resulted in a positive plant–soil feedback for soil nutrients,and a negative plant–soil feedback for growth in native S.calendulacea.Our findings also suggest that the effects of litter decomposition from an invasive plant on soils and native species can vary significantly depending on the soil depth at which the litter is deposited.Future studies should focus on plant–soil feedback for more native and invasive species in invaded habitats,and the effects of invasive litter in more soil types and at greater soil depths.

Frequency of otitis media with effusion among children aged 1-5 years presenting to immunization center of tertiary care hospitals,Rawalpindi

Objective:We conducted this study to assess the etiopathogenic relation of otitis media with effusion(OME)in a group of children aged 1-5 years among the local population of Rawalpindi.Methods:This was a cross-sectional retrospective study.Study was conducted among the children presenting to the immunization center of three tertiary care hospitals of Rawalpindi.Otitis media was assessed by clinical examination and tympanometry from August 2019 to January 2020.Multi-factor regression analysis was then applied to recognize the statistical significance and association of various risk factors to OME.Results:Out of 400 children enrolled in this study,108(27.0%)had OME,out of which 65(60.2%)were males and 30(27.8%)were of age group 2-3 years.Multivariable regression analysis of risk factors associated with OME showed it was strongly associated with snoring(P<0.001),last year symptoms(attack of ear aches with hearing loss[P=0.002]),drugs(URTI antibiotics[P=0.026],All 3 drugs[P=0.013]).Conclusions:We found out that OME is a common disease which if not identified or treated timely can lead to other hard to cure health problems.Control of its etiopathogenic factors can play a major role in its prevention.

Theoretical evaluation of dielectric materials for lightning energy harvesting system

This study describes the hypothetical approach to system design to collect and store electrical energy present in a flash of lightning.The system’s operations include the attraction and handling of the electrical charge obtained from lightning flashes.Performance differences arise from three different dielectric materials(rutile,mica and quartz)and the results define the estimated response of the storage system,including charge storage.All the results in this article were obtained through simulation or demonstrated mathematically showing the estimated outcomes of the system.The findings demonstrate that each dielectric material has its own advantages and disadvantages that influence the efficiency of the storage system.Through analysing the distinction of the three materials,it is observed that mica is the most suitable dielectric material,as it has the greatest dielectric strength,which is the main factor in the handling of charge.