N-pivaloyl-Nˊ-（3,4-dichlorophenyl）thiourea （1）： monoclinic, P21/a, a=11.57（1）, b=9.278（8）, c=13.51（1）, β=103.85（1）°, V=1408（2）3 , Z=4, μ=0.598 mm-1 ; N-pivaloyl-N＇-（3,5- dichlorophenyl）thiour...N-pivaloyl-Nˊ-（3,4-dichlorophenyl）thiourea （1）： monoclinic, P21/a, a=11.57（1）, b=9.278（8）, c=13.51（1）, β=103.85（1）°, V=1408（2）3 , Z=4, μ=0.598 mm-1 ; N-pivaloyl-N＇-（3,5- dichlorophenyl）thiourea （2）： monoclinic, P21/a, a=7.176（2）, b=16.441（4）, c=11.923（2）, β=92.48（1）°, V=1405.3（6）3 , Z=4, μ=0.600 mm-1 ; N-pivaloyl-Nˊ-（2,6-dichlorophenyl）thiourea （3）： orthorhombic, Pnma, a=26.79（1）, b=8.780（4）, c=5.955（3）, V=1400.7（11）3 , Z=4, μ=0.601 mm-1 . All three complexes have an intramolecular hydrogen bond between NˊH and the carbonyl oxygen. Solution 1H NMR studies （CDCl3） show the NH resonance considerable downfield for each thiourea and their positions, as well as that of NH, is affected by substituents on the phenyl ring.展开更多
A novel fused isocoumarin skeleton has been synthesized through selective domino multicyclizations by mixing homothallic acid and 2,3-diphenylacryloyl chloride at 200℃ under catalyst and solvent free reaction conditi...A novel fused isocoumarin skeleton has been synthesized through selective domino multicyclizations by mixing homothallic acid and 2,3-diphenylacryloyl chloride at 200℃ under catalyst and solvent free reaction conditions. Six fused rings with two stereogenic centers were assembled in a convenient onepot operation in good yield. The resulting hexacyclic fused isocoumarin skeleton and its stereochemistry was fully characterized and unambiguously confirmed by X-ray diffraction analysis.展开更多
基金the Quaid-I-Azam University,Islamabad,Pakistan for Post-doctoral Fellowship and financial support
文摘N-pivaloyl-Nˊ-（3,4-dichlorophenyl）thiourea （1）： monoclinic, P21/a, a=11.57（1）, b=9.278（8）, c=13.51（1）, β=103.85（1）°, V=1408（2）3 , Z=4, μ=0.598 mm-1 ; N-pivaloyl-N＇-（3,5- dichlorophenyl）thiourea （2）： monoclinic, P21/a, a=7.176（2）, b=16.441（4）, c=11.923（2）, β=92.48（1）°, V=1405.3（6）3 , Z=4, μ=0.600 mm-1 ; N-pivaloyl-Nˊ-（2,6-dichlorophenyl）thiourea （3）： orthorhombic, Pnma, a=26.79（1）, b=8.780（4）, c=5.955（3）, V=1400.7（11）3 , Z=4, μ=0.601 mm-1 . All three complexes have an intramolecular hydrogen bond between NˊH and the carbonyl oxygen. Solution 1H NMR studies （CDCl3） show the NH resonance considerable downfield for each thiourea and their positions, as well as that of NH, is affected by substituents on the phenyl ring.
基金supported by the Higher Education Commission (HEC),Govt.of Pakistan for financial support
文摘A novel fused isocoumarin skeleton has been synthesized through selective domino multicyclizations by mixing homothallic acid and 2,3-diphenylacryloyl chloride at 200℃ under catalyst and solvent free reaction conditions. Six fused rings with two stereogenic centers were assembled in a convenient onepot operation in good yield. The resulting hexacyclic fused isocoumarin skeleton and its stereochemistry was fully characterized and unambiguously confirmed by X-ray diffraction analysis.
