Background: Immune dysfunction and a higher risk of uterine infections are characteristics of the transition into lactation in dairy cows. The supply of complexed trace minerals, which are more bioavailable, could hel...Background: Immune dysfunction and a higher risk of uterine infections are characteristics of the transition into lactation in dairy cows. The supply of complexed trace minerals, which are more bioavailable, could help overcome the greater needs of these nutrients in tissues around parturition and early lactation.Results: Twenty Holstein cows received an oral bolus with a mix of inorganic trace minerals(INO) or complexed trace minerals(AAC) to achieve 75, 65, 11, and 1 ppm supplemental Zn, Mn, Cu, and Co, respectively, in the total diet dry matter from -30 d through +30 d relative to parturition. Blood for polymorphonuclear leukocyte(PMNL) isolation was collected at-30,-15, +10, and + 30 d relative to parturition, whereas endometrium biopsies were performed at +14 and +30 d. Feeding AAC led to greater PMNL expression of genes related with inflammation response(DDX58), oxidative stress response(MPO), eicosanoid metabolism(PLA2G4A and ALOX5AP), transcription regulation(PPARG), and cellular adhesion(TLN1). The upregulation by AAC in endometrium of genes related with inflammation response( TLR2, TLR4, NFKB1, TNF, IL6, IL1 B, IL10, IL8), prostaglandin synthesis(PTGS2, PTGES), and antioxidant responses(NFE2 L2, SOD1) indicated a faster remodeling of uterine tissue and potentially greater capacity to control a local bacterial invasion.Conclusions: Data indicate that trace mineral supplementation from amino acid complexes improves PMNL activity and allows the prompt recovery of uterine tissue during early lactation. As such, the benefits of complexed trace minerals extend beyond an improvement of liver function and productive performance.展开更多
It is challenging to prepare a binary assembled metal-organic framework(MOF) by anisotropic epitaxial growth method. Besides, nanocages(NCs) with hollow structures are often constructed to improve microwave absorbing ...It is challenging to prepare a binary assembled metal-organic framework(MOF) by anisotropic epitaxial growth method. Besides, nanocages(NCs) with hollow structures are often constructed to improve microwave absorbing abilities. Herein, we combine the selective epitaxial growth and hollow engineering technologies to fabricate hybrid MOF-derived NCs. Benefiting from the unique nanocage/porous structure,complementary magnetic/dielectric components and suitable impedance matching characteristics, the optimized absorber(CoNi/TiO@PC-NCs) exhibits unique microwave absorbing properties. It is worth noting that the minimum reflection loss(RLmin) of the absorber reaches-65.3 dB, and the overall effective absorption bandwidth(EAB, RL <-10 dB) covers 15.1 GHz(2.9–18 GHz). The maximum EAB under a single thickness covers 4.4 GHz, displaying skipping dual-band coverages at both high and low frequencies. This work might provide a novel perspective for the synthesis of assembled MOF-derived absorbers.展开更多
基金Fernanda Batistel(FB)was supported by Coordenacao de Aperfeicoamento de Pessoal de Nível Superior(CAPES)Juan Loor(JL)was supported by National Institute of Food and Agriculture(Grant:ILLU-538-914)Zinpro Corporation provided support to Juan J.Loor and Michael T.Socha
文摘Background: Immune dysfunction and a higher risk of uterine infections are characteristics of the transition into lactation in dairy cows. The supply of complexed trace minerals, which are more bioavailable, could help overcome the greater needs of these nutrients in tissues around parturition and early lactation.Results: Twenty Holstein cows received an oral bolus with a mix of inorganic trace minerals(INO) or complexed trace minerals(AAC) to achieve 75, 65, 11, and 1 ppm supplemental Zn, Mn, Cu, and Co, respectively, in the total diet dry matter from -30 d through +30 d relative to parturition. Blood for polymorphonuclear leukocyte(PMNL) isolation was collected at-30,-15, +10, and + 30 d relative to parturition, whereas endometrium biopsies were performed at +14 and +30 d. Feeding AAC led to greater PMNL expression of genes related with inflammation response(DDX58), oxidative stress response(MPO), eicosanoid metabolism(PLA2G4A and ALOX5AP), transcription regulation(PPARG), and cellular adhesion(TLN1). The upregulation by AAC in endometrium of genes related with inflammation response( TLR2, TLR4, NFKB1, TNF, IL6, IL1 B, IL10, IL8), prostaglandin synthesis(PTGS2, PTGES), and antioxidant responses(NFE2 L2, SOD1) indicated a faster remodeling of uterine tissue and potentially greater capacity to control a local bacterial invasion.Conclusions: Data indicate that trace mineral supplementation from amino acid complexes improves PMNL activity and allows the prompt recovery of uterine tissue during early lactation. As such, the benefits of complexed trace minerals extend beyond an improvement of liver function and productive performance.
基金This work was financially supported by the National Natural Science Foundation of China(Nos.21975206 and 21901206)the Foundation of Shaanxi Province Natural Science Basic Research Program(No.2020JQ-146)the Innovation Foundation for Doctor Dissertation of Northwestern Polytechnical University。
文摘It is challenging to prepare a binary assembled metal-organic framework(MOF) by anisotropic epitaxial growth method. Besides, nanocages(NCs) with hollow structures are often constructed to improve microwave absorbing abilities. Herein, we combine the selective epitaxial growth and hollow engineering technologies to fabricate hybrid MOF-derived NCs. Benefiting from the unique nanocage/porous structure,complementary magnetic/dielectric components and suitable impedance matching characteristics, the optimized absorber(CoNi/TiO@PC-NCs) exhibits unique microwave absorbing properties. It is worth noting that the minimum reflection loss(RLmin) of the absorber reaches-65.3 dB, and the overall effective absorption bandwidth(EAB, RL <-10 dB) covers 15.1 GHz(2.9–18 GHz). The maximum EAB under a single thickness covers 4.4 GHz, displaying skipping dual-band coverages at both high and low frequencies. This work might provide a novel perspective for the synthesis of assembled MOF-derived absorbers.