Zika virus(ZIKV)is the causative agent of a viral infection that causes neurological complications in newborns and adults worldwide.Its wide transmission route and alarming spread rates are of great concern to the sci...Zika virus(ZIKV)is the causative agent of a viral infection that causes neurological complications in newborns and adults worldwide.Its wide transmission route and alarming spread rates are of great concern to the scientific community.Numerous trials have been conducted to develop treatment options for ZIKV infection.This review highlights the latest developments in the fields of vaccinology and pharmaceuticals developments for ZIKV infection.A systematic and comprehensive approach was used to gather relevant and up-to-date data so that inferences could be made about the gaps in therapeutic development.The results indicate that several therapeutic interventions are being tested against ZIKV infection,such as DNA vaccines,subunit vaccines,live-attenuated vaccines,virus-vector-based vaccines,inactivated vaccines,virus-like particles,and mRNA-based vaccines.In addition,approved anti-ZIKV drugs that can reduce the global burden are discussed.Although many vaccine candidates for ZIKV are at different stages of development,none of them have received Food and Drug Authority approval for use up to now.The issue of side effects associated with these drugs in vulnerable newborns and pregnant women is a major obstacle in the therapeutic pathway.展开更多
Drought is one of the hot topics needing urgent attention in the current era of climate change.It massively disturbs the rice growth and productivity and is becoming a serious threat.The drought avoidance strategies i...Drought is one of the hot topics needing urgent attention in the current era of climate change.It massively disturbs the rice growth and productivity and is becoming a serious threat.The drought avoidance strategies in rice include stomatal closure,cellular adaptation and changes in root development.Moreover,the endogenous plant hormones(abscisic acid and jasmonic acid)and reactive oxygen species have paramount importance in drought tolerance in rice.The drought tolerance induces modification in biochemical,molecular and physiological properties of plants.At the molecular level,expression of several transcription-factors is modulated which further determine the activation of drought responsive gene families.Mitogen activated protein kinases and Ca signaling pathways initiate an array of signaling cascade for mediating the gene expression in rice.Approaches,conventional breeding methods combined with modern emerging techniques such as genetic engineering,to improve rice drought tolerance were discussed.This review provided recent insights into major regulatory factors against drought stress,signaling mechanisms and molecular engineering strategies(including conventional transgenic and recent genome editing approaches)to induce drought tolerance in rice.展开更多
In this paper,negative selection and genetic algorithms are combined and an improved bi-objective optimization scheme is presented to achieve optimized negative selection algorithm detectors.The main aim of the optima...In this paper,negative selection and genetic algorithms are combined and an improved bi-objective optimization scheme is presented to achieve optimized negative selection algorithm detectors.The main aim of the optimal detector generation technique is maximal nonself space coverage with reduced number of diversified detectors.Conventionally,researchers opted clonal selection based optimization methods to achieve the maximal nonself coverage milestone;however,detectors cloning process results in generation of redundant similar detectors and inefficient detector distribution in nonself space.In approach proposed in the present paper,the maximal nonself space coverage is associated with bi-objective optimization criteria including minimization of the detector overlap and maximization of the diversity factor of the detectors.In the proposed methodology,a novel diversity factorbased approach is presented to obtain diversified detector distribution in the nonself space.The concept of diversified detector distribution is studied for detector coverage with 2-dimensional pentagram and spiral self-patterns.Furthermore,the feasibility of the developed fault detection methodology is tested the fault detection of induction motor inner race and outer race bearings.展开更多
基金This work is supported by the United Arab Emirates University UPAR(Grant No.G3458).
文摘Zika virus(ZIKV)is the causative agent of a viral infection that causes neurological complications in newborns and adults worldwide.Its wide transmission route and alarming spread rates are of great concern to the scientific community.Numerous trials have been conducted to develop treatment options for ZIKV infection.This review highlights the latest developments in the fields of vaccinology and pharmaceuticals developments for ZIKV infection.A systematic and comprehensive approach was used to gather relevant and up-to-date data so that inferences could be made about the gaps in therapeutic development.The results indicate that several therapeutic interventions are being tested against ZIKV infection,such as DNA vaccines,subunit vaccines,live-attenuated vaccines,virus-vector-based vaccines,inactivated vaccines,virus-like particles,and mRNA-based vaccines.In addition,approved anti-ZIKV drugs that can reduce the global burden are discussed.Although many vaccine candidates for ZIKV are at different stages of development,none of them have received Food and Drug Authority approval for use up to now.The issue of side effects associated with these drugs in vulnerable newborns and pregnant women is a major obstacle in the therapeutic pathway.
文摘Drought is one of the hot topics needing urgent attention in the current era of climate change.It massively disturbs the rice growth and productivity and is becoming a serious threat.The drought avoidance strategies in rice include stomatal closure,cellular adaptation and changes in root development.Moreover,the endogenous plant hormones(abscisic acid and jasmonic acid)and reactive oxygen species have paramount importance in drought tolerance in rice.The drought tolerance induces modification in biochemical,molecular and physiological properties of plants.At the molecular level,expression of several transcription-factors is modulated which further determine the activation of drought responsive gene families.Mitogen activated protein kinases and Ca signaling pathways initiate an array of signaling cascade for mediating the gene expression in rice.Approaches,conventional breeding methods combined with modern emerging techniques such as genetic engineering,to improve rice drought tolerance were discussed.This review provided recent insights into major regulatory factors against drought stress,signaling mechanisms and molecular engineering strategies(including conventional transgenic and recent genome editing approaches)to induce drought tolerance in rice.
文摘In this paper,negative selection and genetic algorithms are combined and an improved bi-objective optimization scheme is presented to achieve optimized negative selection algorithm detectors.The main aim of the optimal detector generation technique is maximal nonself space coverage with reduced number of diversified detectors.Conventionally,researchers opted clonal selection based optimization methods to achieve the maximal nonself coverage milestone;however,detectors cloning process results in generation of redundant similar detectors and inefficient detector distribution in nonself space.In approach proposed in the present paper,the maximal nonself space coverage is associated with bi-objective optimization criteria including minimization of the detector overlap and maximization of the diversity factor of the detectors.In the proposed methodology,a novel diversity factorbased approach is presented to obtain diversified detector distribution in the nonself space.The concept of diversified detector distribution is studied for detector coverage with 2-dimensional pentagram and spiral self-patterns.Furthermore,the feasibility of the developed fault detection methodology is tested the fault detection of induction motor inner race and outer race bearings.
基金supported by the National Natural Science Foundation of China(51471127,51431007 and 51371134)the Program for Young Scientific New-star in Shaanxi Province of China(2014KJXX-35)+2 种基金the Innovation Capability Support Program of Shaanxi(2018PT-28 and 2017KTPT-04)Shenzhen Science and Technology Project(JCYJ20180507182246321)the Fundamental Research Funds for Central Universities of China。