Brookline Ave nue, Boston, MA 02215, United States] Background: The association of light to moderate alcohol consumption with ris k for ischemic stroke remains controversial, as do the roles of beverage type an d drin...Brookline Ave nue, Boston, MA 02215, United States] Background: The association of light to moderate alcohol consumption with ris k for ischemic stroke remains controversial, as do the roles of beverage type an d drinking pattern. Objective: To assess the association of drinking patterns an d beverage type with risk for ischemic stroke among men. Design: Prospective coh ort study. Setting: United States. Participants: 38156 male health professionals who were free of known cardiovascular disease or cancer at baseline in 1986. Me asurements: With a semi quantitative food frequency questionnaire, the autho rs individually ascertained consumption of regular and light beer, red and white wine, and liquor every 4 years. Alcohol consumption was categorized as light (0 .1 to 9.9 g/d, or < 1 drink daily), moderate (10.0 to 29.9 g/d, or 1 to 2 drinks daily), and heavier (≥ 30.0 g/d, or ≥ 3 drinks daily). Results: During a foll ow up period of 14 years, 412 cases of incident ischemic stroke were documente d. Compared with abstainers, light drinkers had a multivariate adjusted relati ve risk of 0.99 (95% CI, 0.72 to 1.37), moderate drinkers had a multivariate adjusted relative risk of 1.26 (CI, 0.90 to 1.76), and heavier drinkers had a m ultivariate adjusted relative risk of 1.42 (CI, 0.97 to 2.09; P =0.01 for tren d). Consumption of 10.0 to 29.9 g of alcohol per day on 3 to 4 days per week app eared to be associated with the lowest risk (relative risk, 0.68 [CI, 0.44 to 1. 05]). Red wine consumption was inversely associated with risk in a graded manner (P = 0.02 for trend), but other beverages were not. The apparently higher risk for ischemic stroke with heavier alcohol use appeared to be most pronounced for the embolic subtype. Limitations: This study had limited power to examine specif ic drinking patterns and heavy drinking and could not assess risk for hemorrhagi c stroke. Conclusions: In this sample of male health professionals, light and mo derate average alcohol use was generally not associated with an increased risk f or ischemic stroke, although drinking pattern and beverage type modified this re lation. Intake of more than 2 drinks per day may be associated with a higher ris k for ischemic stroke.展开更多
Cross-sectional and limited prospective evidence has suggested that inflammatory markers may predict for the risk of atrial fibrillation(AF). In a prospective cohort study, we studied the risk of incident AF among 8,8...Cross-sectional and limited prospective evidence has suggested that inflammatory markers may predict for the risk of atrial fibrillation(AF). In a prospective cohort study, we studied the risk of incident AF among 8,870 women and men free of cardiovascular disease enrolled in the Copenhagen City Heart Study. We measured plasma fibrinogen and serum albumin levels at a study visit from 1991 to 1994. We identified 286 subsequent cases of AF during a mean of 7.5 years of follow-up by a validated nationwide registry of all hospitalizations. The fibrinogen levels at baseline were associated with a higher risk of AF, with a multivariate-adjusted hazard ratio for the highest versus lowest quartiles of 1.98(95%confidence interval[CI] 0.94 to 4.17) among men and 2.14(95%CI 1.15 to 3.96) among women. The albumin levels were inversely associated with the risk of AF among women(hazard ratio 0.47, 95%CI 0.28 to 0.77) but not among men(hazard ratio 1.01, 95%CI 0.56 to 1.84). Additional adjustment for cases of coronary heart disease, congestive heart failure, and stroke that occurred during follow-up did not attenuate these associations. In conclusion, higher levels of fibrinogen and lower levels of albumin were prospectively associated with a higher risk of AF, even accounting for their relation with the risk of cardiovascular disease. These findings support the hypothesis that inflammation contributes to the etiology of AF.展开更多
Objectives: We investigated the association between alcohol consumption and incident congestive heart failure(CHF) both overall and after adjusting for incident myocardial infarction(MI). Background: Moderate alcohol ...Objectives: We investigated the association between alcohol consumption and incident congestive heart failure(CHF) both overall and after adjusting for incident myocardial infarction(MI). Background: Moderate alcohol consumption has been associated with lower risk of CHF and MI. Methods: The Cardiovascular Health study, a prospective cohort study of cardiovascular disease risk factors and outcomes, followed 5,888 subjects ≥65 years old for 7 to 10 years. Cox models were used to estimate the adjusted risk of CHF by reported alcohol consumption. Results: There were 5,595 subjects at baseline at risk for incident CHF with alcohol data and 1,056 events during follow-up. Compared with abstainers, the adjusted risk of CHF was lower among subjects who reported consuming 1 to 6 drinks per week(hazard ratio[HR] 0.82, 95%confidence interval[CI] 0.67 to 1.00, p=0.05) and 7 to 13 drinks per week(HR 0.66, 95%CI 0.47 to 0.91, p=0.01). Time-dependent adjustment for incident MI altered only slightly the association between moderate alcohol consumption and CHF(for 1 to 6 drinks per week, HR 0.84, 95%CI 0.65 to 1.04; for 7 to 13 drinks per week, HR 0.69, 95%CI 0.49 to 0.99). Baseline former drinkers had a higher risk of CHF than abstainers(HR 1.51, p< 0.01), but those who quit during the study did not have a higher risk(HR 0.83, 95%CI 0.66 to 1.03). Conclusions: Moderate alcohol use is associated with a lower risk of incident CHF among older adults, even after accounting for incident MI and other factors.展开更多
文摘Brookline Ave nue, Boston, MA 02215, United States] Background: The association of light to moderate alcohol consumption with ris k for ischemic stroke remains controversial, as do the roles of beverage type an d drinking pattern. Objective: To assess the association of drinking patterns an d beverage type with risk for ischemic stroke among men. Design: Prospective coh ort study. Setting: United States. Participants: 38156 male health professionals who were free of known cardiovascular disease or cancer at baseline in 1986. Me asurements: With a semi quantitative food frequency questionnaire, the autho rs individually ascertained consumption of regular and light beer, red and white wine, and liquor every 4 years. Alcohol consumption was categorized as light (0 .1 to 9.9 g/d, or < 1 drink daily), moderate (10.0 to 29.9 g/d, or 1 to 2 drinks daily), and heavier (≥ 30.0 g/d, or ≥ 3 drinks daily). Results: During a foll ow up period of 14 years, 412 cases of incident ischemic stroke were documente d. Compared with abstainers, light drinkers had a multivariate adjusted relati ve risk of 0.99 (95% CI, 0.72 to 1.37), moderate drinkers had a multivariate adjusted relative risk of 1.26 (CI, 0.90 to 1.76), and heavier drinkers had a m ultivariate adjusted relative risk of 1.42 (CI, 0.97 to 2.09; P =0.01 for tren d). Consumption of 10.0 to 29.9 g of alcohol per day on 3 to 4 days per week app eared to be associated with the lowest risk (relative risk, 0.68 [CI, 0.44 to 1. 05]). Red wine consumption was inversely associated with risk in a graded manner (P = 0.02 for trend), but other beverages were not. The apparently higher risk for ischemic stroke with heavier alcohol use appeared to be most pronounced for the embolic subtype. Limitations: This study had limited power to examine specif ic drinking patterns and heavy drinking and could not assess risk for hemorrhagi c stroke. Conclusions: In this sample of male health professionals, light and mo derate average alcohol use was generally not associated with an increased risk f or ischemic stroke, although drinking pattern and beverage type modified this re lation. Intake of more than 2 drinks per day may be associated with a higher ris k for ischemic stroke.
文摘Cross-sectional and limited prospective evidence has suggested that inflammatory markers may predict for the risk of atrial fibrillation(AF). In a prospective cohort study, we studied the risk of incident AF among 8,870 women and men free of cardiovascular disease enrolled in the Copenhagen City Heart Study. We measured plasma fibrinogen and serum albumin levels at a study visit from 1991 to 1994. We identified 286 subsequent cases of AF during a mean of 7.5 years of follow-up by a validated nationwide registry of all hospitalizations. The fibrinogen levels at baseline were associated with a higher risk of AF, with a multivariate-adjusted hazard ratio for the highest versus lowest quartiles of 1.98(95%confidence interval[CI] 0.94 to 4.17) among men and 2.14(95%CI 1.15 to 3.96) among women. The albumin levels were inversely associated with the risk of AF among women(hazard ratio 0.47, 95%CI 0.28 to 0.77) but not among men(hazard ratio 1.01, 95%CI 0.56 to 1.84). Additional adjustment for cases of coronary heart disease, congestive heart failure, and stroke that occurred during follow-up did not attenuate these associations. In conclusion, higher levels of fibrinogen and lower levels of albumin were prospectively associated with a higher risk of AF, even accounting for their relation with the risk of cardiovascular disease. These findings support the hypothesis that inflammation contributes to the etiology of AF.
文摘Objectives: We investigated the association between alcohol consumption and incident congestive heart failure(CHF) both overall and after adjusting for incident myocardial infarction(MI). Background: Moderate alcohol consumption has been associated with lower risk of CHF and MI. Methods: The Cardiovascular Health study, a prospective cohort study of cardiovascular disease risk factors and outcomes, followed 5,888 subjects ≥65 years old for 7 to 10 years. Cox models were used to estimate the adjusted risk of CHF by reported alcohol consumption. Results: There were 5,595 subjects at baseline at risk for incident CHF with alcohol data and 1,056 events during follow-up. Compared with abstainers, the adjusted risk of CHF was lower among subjects who reported consuming 1 to 6 drinks per week(hazard ratio[HR] 0.82, 95%confidence interval[CI] 0.67 to 1.00, p=0.05) and 7 to 13 drinks per week(HR 0.66, 95%CI 0.47 to 0.91, p=0.01). Time-dependent adjustment for incident MI altered only slightly the association between moderate alcohol consumption and CHF(for 1 to 6 drinks per week, HR 0.84, 95%CI 0.65 to 1.04; for 7 to 13 drinks per week, HR 0.69, 95%CI 0.49 to 0.99). Baseline former drinkers had a higher risk of CHF than abstainers(HR 1.51, p< 0.01), but those who quit during the study did not have a higher risk(HR 0.83, 95%CI 0.66 to 1.03). Conclusions: Moderate alcohol use is associated with a lower risk of incident CHF among older adults, even after accounting for incident MI and other factors.
