The strength of signal downstream of the B-cell receptor(BCR)determines the positive and negative selection of B cells.Expression of a functional BCR is required for the selection of immature B cells into the peripher...The strength of signal downstream of the B-cell receptor(BCR)determines the positive and negative selection of B cells.Expression of a functional BCR is required for the selection of immature B cells into the peripheral repertoire in the absence of antigen;but selection is also modulated by avidity and affinity-dependent interactions with self and foreign antigens.展开更多
文摘The strength of signal downstream of the B-cell receptor(BCR)determines the positive and negative selection of B cells.Expression of a functional BCR is required for the selection of immature B cells into the peripheral repertoire in the absence of antigen;but selection is also modulated by avidity and affinity-dependent interactions with self and foreign antigens.
