Prevalence and antibiogram of bacterial isolates from urinary tract infections at Dessie Health Research Laboratory,Ethiopia

Objective:To determine the prevalence and antimicrobial susceptibility of bacteria from suspected urinary tract infections.Methods:A retrospective analysis of Imcterial pathogens and their antimicrobial susceptibility was done on urine samples at Dessic Regional Laboratory in the period 2003 to 2010.Antimicrobial susceptibility tests were done using disc diffusion technique as per the standard of Kirby-Bauer method.Results:The male to female ratio of the patients was 1:1.96.Of the total 1404 samples..119(22.7%,were culture positive.Escherirhia coli was the dominant isolate(63.6%) followed by Klebsiella spp.(8.5%) and Proteus spp.(8.2%).The overall resistance rates to erythromycin,amoxycillin,and tetracycline were 85.6%,88.9%and 76.7%,respectively,The three most frequently isolated bacteria had resistance rates of 80.1%-90.0%to.amoxycillin,and tetracycline and sensitivity rates of 0to 25%to nitrofurantoin,ciprofloxacin and genlamiein.Antibiogram of isolates showed that 152i47.85%isolates were resistance to two and more antimicrobials.Conclusions:In the study area resistance rates to erythromycin,amoxycillin and tetracycline were high.Since most isolates were sensitive to nitrofurantoin and gentamicin.they are considered as appropriate antimicrobials for empirical treatment urinary tract infections.