AIM: To investigate the changes in plasminogen activity level during mesenteric ischemia. METHODS: We performed laparotomy in 90 female Wistar-Albino rats (average weight 230 g). In sham groups (SL) (GroupsⅠand Ⅱ) t...AIM: To investigate the changes in plasminogen activity level during mesenteric ischemia. METHODS: We performed laparotomy in 90 female Wistar-Albino rats (average weight 230 g). In sham groups (SL) (GroupsⅠand Ⅱ) the superior mesenteric artery (SMA) and vein (SMV) were explored, but not tied. In SMA groups (Groups Ⅲ and Ⅳ) the SMA was ligated, and in SMV groups (Groups Ⅴ and Ⅵ) the SMV was ligated. On re-laparatomy 2 mL of blood was drawn at 1 h in groupsⅠ, Ⅲ and Ⅴ, and at 3 h in groups Ⅱ, Ⅳ and Ⅵ. Plasminogen levels were assessed and comparisons were made between groups and within each group. RESULTS: The mean plasminogen activity in the SL group was significantly higher than SMA (25.1 ± 10.8 vs 11.8 ± 4.6, P < 0.001) or SMV (25.1 ± 10.8 vs 13.7 ± 4.4, P < 0.001) groups both at 1 h and at 3 h (29.8 ± 8.9 vs 15.1 ± 5.7, P < 0.0001; 29.8 ± 8.9 vs 14.2 ± 2.9, P < 0.0001). There were no significant differences between the values of SMA and SMV groups at 1 h (P = 0.28) and at 3 h (P = 0.71). In each group, plasminogen activity levels did not change significantly between the two measurements performed at 1 h and 3 h. CONCLUSION: We conclude that blood plasminogen activities decrease during early phases of both arterial and venous mesenteric ischemia which may be a useful marker for early diagnosis.展开更多
Duodenal duplication,a rare congenital malformation,can also be observed in adulthood.Although it can be cystic or tubular,communicating or non-communicating,cystic and non-communicating forms are the most common.Seve...Duodenal duplication,a rare congenital malformation,can also be observed in adulthood.Although it can be cystic or tubular,communicating or non-communicating,cystic and non-communicating forms are the most common.Several complications,such as obstruction,bleeding,perforation and pancreatitis,may result.Optimal treatment is total excision,although endoscopic procedures have also been described in appropriate cases.If total excision is not possible,subtotal excision and internal derivation can be performed.The 38-year-old woman presented here had occasional attacks of abdominal pain and obstruction,and we considered the diagnosis of duodenal duplication by abdominal computerized tomography.As we confirmed the diagnosis with operative findings and histopathological signs,we treated her with subtotal excision and intraduodenal cystoduodenostomy.展开更多
文摘AIM: To investigate the changes in plasminogen activity level during mesenteric ischemia. METHODS: We performed laparotomy in 90 female Wistar-Albino rats (average weight 230 g). In sham groups (SL) (GroupsⅠand Ⅱ) the superior mesenteric artery (SMA) and vein (SMV) were explored, but not tied. In SMA groups (Groups Ⅲ and Ⅳ) the SMA was ligated, and in SMV groups (Groups Ⅴ and Ⅵ) the SMV was ligated. On re-laparatomy 2 mL of blood was drawn at 1 h in groupsⅠ, Ⅲ and Ⅴ, and at 3 h in groups Ⅱ, Ⅳ and Ⅵ. Plasminogen levels were assessed and comparisons were made between groups and within each group. RESULTS: The mean plasminogen activity in the SL group was significantly higher than SMA (25.1 ± 10.8 vs 11.8 ± 4.6, P < 0.001) or SMV (25.1 ± 10.8 vs 13.7 ± 4.4, P < 0.001) groups both at 1 h and at 3 h (29.8 ± 8.9 vs 15.1 ± 5.7, P < 0.0001; 29.8 ± 8.9 vs 14.2 ± 2.9, P < 0.0001). There were no significant differences between the values of SMA and SMV groups at 1 h (P = 0.28) and at 3 h (P = 0.71). In each group, plasminogen activity levels did not change significantly between the two measurements performed at 1 h and 3 h. CONCLUSION: We conclude that blood plasminogen activities decrease during early phases of both arterial and venous mesenteric ischemia which may be a useful marker for early diagnosis.
文摘Duodenal duplication,a rare congenital malformation,can also be observed in adulthood.Although it can be cystic or tubular,communicating or non-communicating,cystic and non-communicating forms are the most common.Several complications,such as obstruction,bleeding,perforation and pancreatitis,may result.Optimal treatment is total excision,although endoscopic procedures have also been described in appropriate cases.If total excision is not possible,subtotal excision and internal derivation can be performed.The 38-year-old woman presented here had occasional attacks of abdominal pain and obstruction,and we considered the diagnosis of duodenal duplication by abdominal computerized tomography.As we confirmed the diagnosis with operative findings and histopathological signs,we treated her with subtotal excision and intraduodenal cystoduodenostomy.
