Toxic hepatitis or drug-induced liver injury encompasses a spectrum of clinical disease ranging from mild biochemical abnormalities to acute liver failure.The advantages of a long half-life,wide spectrum,high tissue p...Toxic hepatitis or drug-induced liver injury encompasses a spectrum of clinical disease ranging from mild biochemical abnormalities to acute liver failure.The advantages of a long half-life,wide spectrum,high tissue penetration rate,and a good safety profile,make ceftriaxone,a third-generation cephalosporin,a frequent choice in the treatment of childhood infections.Previous studies have reported a few cases of high aspartate aminotransferase and alanine aminotransferase levels,along with three cases of hepatitis caused by ceftriaxone.Here,we report a case of drug-induced toxic hepatitis in a patient who was treated with ceftriaxone for acute tonsillitis.展开更多
Celiac disease(CD) is manifested by a variety of clinical signs and symptoms that may begin either in childhood or adult life.Neurological symptoms without signs of malabsorption have been observed for a long time in ...Celiac disease(CD) is manifested by a variety of clinical signs and symptoms that may begin either in childhood or adult life.Neurological symptoms without signs of malabsorption have been observed for a long time in CD.In this report,an 8-year-old girl with CD presented with rarely seen dilated cardiomyopathy and stroke.The girl was admitted with left side weakness.Her medical history indicated abdominal distention,chronic diarrhea,failure to thrive,and geophagia.On physical examination,short stature,pale skin and a grade 2 of 6 systolic murmur were detected.Muscle strength was 0/5 on the left side,and 5/5 on the right side.Coagulation examinations were normal.Tests for collagen tissue diseases were negative.Factor V Leiden and prothrombin GA20210 mutations were negative.Tandem mass spectrophotometry and blood carnitine profiles were normal.Brain magnetic resonance imaging and cerebral angiography showed an infarction area at the basal ganglia level.Examinations of serologic markers and intestinal biopsy revealed CD.We emphasize that in differential diagnosis of ischemic stroke,CD should be kept in mind.展开更多
文摘Toxic hepatitis or drug-induced liver injury encompasses a spectrum of clinical disease ranging from mild biochemical abnormalities to acute liver failure.The advantages of a long half-life,wide spectrum,high tissue penetration rate,and a good safety profile,make ceftriaxone,a third-generation cephalosporin,a frequent choice in the treatment of childhood infections.Previous studies have reported a few cases of high aspartate aminotransferase and alanine aminotransferase levels,along with three cases of hepatitis caused by ceftriaxone.Here,we report a case of drug-induced toxic hepatitis in a patient who was treated with ceftriaxone for acute tonsillitis.
文摘Celiac disease(CD) is manifested by a variety of clinical signs and symptoms that may begin either in childhood or adult life.Neurological symptoms without signs of malabsorption have been observed for a long time in CD.In this report,an 8-year-old girl with CD presented with rarely seen dilated cardiomyopathy and stroke.The girl was admitted with left side weakness.Her medical history indicated abdominal distention,chronic diarrhea,failure to thrive,and geophagia.On physical examination,short stature,pale skin and a grade 2 of 6 systolic murmur were detected.Muscle strength was 0/5 on the left side,and 5/5 on the right side.Coagulation examinations were normal.Tests for collagen tissue diseases were negative.Factor V Leiden and prothrombin GA20210 mutations were negative.Tandem mass spectrophotometry and blood carnitine profiles were normal.Brain magnetic resonance imaging and cerebral angiography showed an infarction area at the basal ganglia level.Examinations of serologic markers and intestinal biopsy revealed CD.We emphasize that in differential diagnosis of ischemic stroke,CD should be kept in mind.
