AIM: To evaluate susceptibility of Helicobacter pylori to amoxicillin and clarithromycin in end-stage renal disease (ESRD) patients and non-uremic controls.METHODS: The subjects with dyspeptic complaints were 33 ESRD ...AIM: To evaluate susceptibility of Helicobacter pylori to amoxicillin and clarithromycin in end-stage renal disease (ESRD) patients and non-uremic controls.METHODS: The subjects with dyspeptic complaints were 33 ESRD patients and 46 age- and sex-matched nonuremic controls who exhibited H pylori on antral biopsy specimens. The two groups were age and sex matched.The H pylori strains' pattern of susceptibility to amoxicillin and clarithromycin was investigated with the agar dilution technique.RESULTS: None of the H pylori strains from either group showed resistance to amoxicillin with the agar dilution method. Twelve (36.4%) of the ESRD group strains and 7 (15.2%) of the control group strains showed resistance to clarithromycin, and this difference was statistically significant (P＜0.05).CONCLUSION: Resistance to amoxicillin does not appear to be an important problem in H pylori-infected ESRD and non-uremic patients in our region. In contrast, the rates of resistance to clarithromycin are high, particularly in the ESRD population.展开更多
Sarcopenia("sarx" for muscle,"penia" for loss) is an important problem in the elderly.Although muscle loss is a part of natural aging,excessive loss that limits physical activity is considered path...Sarcopenia("sarx" for muscle,"penia" for loss) is an important problem in the elderly.Although muscle loss is a part of natural aging,excessive loss that limits physical activity is considered pathological.Sarcopenia is associated with age,malnutrition,physical inactivity,inflammatory stress and hormonal changes.Although relationships between sarcopenia and various chronic inflammatory diseases have been shown,the role of rheumatologic disease in sarcopenia development is currently unknown.Our aim in this mini-review was to increase the awareness of clinicians to sarcopenia,and to evaluate studies in which the relationship between sarcopenia and rheumatologic diseases was investigated.We also aimed to determine whether the available literature was sufficient to confirm a strong relationship between these conditions.Although our findings showed that diseases such as rheumatoid arthritis,osteoarthritis and systemic sclerosis may have a role in sarcopenia development and progress,the methodologies and results of the majority of studies were insufficient in determining direct causal relationships.We believe future studies would benefit from focusing on the factors and causes of sarcopenia,with a goal of determining the factors associated with rheumatologic disease that are most effective in sarcopenia development.展开更多
文摘AIM: To evaluate susceptibility of Helicobacter pylori to amoxicillin and clarithromycin in end-stage renal disease (ESRD) patients and non-uremic controls.METHODS: The subjects with dyspeptic complaints were 33 ESRD patients and 46 age- and sex-matched nonuremic controls who exhibited H pylori on antral biopsy specimens. The two groups were age and sex matched.The H pylori strains' pattern of susceptibility to amoxicillin and clarithromycin was investigated with the agar dilution technique.RESULTS: None of the H pylori strains from either group showed resistance to amoxicillin with the agar dilution method. Twelve (36.4%) of the ESRD group strains and 7 (15.2%) of the control group strains showed resistance to clarithromycin, and this difference was statistically significant (P＜0.05).CONCLUSION: Resistance to amoxicillin does not appear to be an important problem in H pylori-infected ESRD and non-uremic patients in our region. In contrast, the rates of resistance to clarithromycin are high, particularly in the ESRD population.
文摘Sarcopenia("sarx" for muscle,"penia" for loss) is an important problem in the elderly.Although muscle loss is a part of natural aging,excessive loss that limits physical activity is considered pathological.Sarcopenia is associated with age,malnutrition,physical inactivity,inflammatory stress and hormonal changes.Although relationships between sarcopenia and various chronic inflammatory diseases have been shown,the role of rheumatologic disease in sarcopenia development is currently unknown.Our aim in this mini-review was to increase the awareness of clinicians to sarcopenia,and to evaluate studies in which the relationship between sarcopenia and rheumatologic diseases was investigated.We also aimed to determine whether the available literature was sufficient to confirm a strong relationship between these conditions.Although our findings showed that diseases such as rheumatoid arthritis,osteoarthritis and systemic sclerosis may have a role in sarcopenia development and progress,the methodologies and results of the majority of studies were insufficient in determining direct causal relationships.We believe future studies would benefit from focusing on the factors and causes of sarcopenia,with a goal of determining the factors associated with rheumatologic disease that are most effective in sarcopenia development.
