The most common complication of orthopedic surgery is implant failure, which can result in catastrophic injury and a significant financial burden for patients. Implant failure can be caused by a variety of factors, th...The most common complication of orthopedic surgery is implant failure, which can result in catastrophic injury and a significant financial burden for patients. Implant failure can be caused by a variety of factors, the most common of which are peri–implant infection(or implantrelated infection), excessive inflammatory response which caused pain and aseptic loosening. Orthopedic surgeons now have a variety of options for treating these issues, including revision surgery, which has demonstrated to be effective. If excessive inflammatory reaction caused by the corrosion and peri–implant infection can be avoided, it will be of enormous social benefits. This review will provide a summary of corrosion and the inflammation reactions due to the corrosion and antimicrobial properties of Mg alloy-based implants covering both in vitro and in vivo studies. The strategies on hindering/overcoming the excessive inflammatory response and enhancing the antimicrobial activity are discussed in this review.展开更多
Magnesium alloys are considered the most suitable absorbable metals for bone fracture fixation implants.The main challenge in absorbable magnesium alloys is their high corrosion/degradation rate that needs to be contr...Magnesium alloys are considered the most suitable absorbable metals for bone fracture fixation implants.The main challenge in absorbable magnesium alloys is their high corrosion/degradation rate that needs to be controlled.Various coatings have been applied to magnesium alloys to slow down their corrosion rates to match their corrosion rate to the regeneration rate of the bone fracture.In this review,a bioactive coating is proposed to slow down the corrosion rate of magnesium alloys and accelerate the bone fracture healing process.The main aim of the bioactive coatings is to enhance the direct attachment of living tissues and thereby facilitate osteoconduction.Hydroxyapatite,collagen type I,recombinant human bone morphogenetic proteins 2,simvastatin,zoledronate,and strontium are six bioactive agents that show high potential for developing a bioactive coating system for high-performance absorbable magnesium bone implants.In addition to coating,the substrate itself can be made bioactive by alloying magnesium with calcium,zinc,copper,and manganese that were found to promote bone regeneration.展开更多
文摘The most common complication of orthopedic surgery is implant failure, which can result in catastrophic injury and a significant financial burden for patients. Implant failure can be caused by a variety of factors, the most common of which are peri–implant infection(or implantrelated infection), excessive inflammatory response which caused pain and aseptic loosening. Orthopedic surgeons now have a variety of options for treating these issues, including revision surgery, which has demonstrated to be effective. If excessive inflammatory reaction caused by the corrosion and peri–implant infection can be avoided, it will be of enormous social benefits. This review will provide a summary of corrosion and the inflammation reactions due to the corrosion and antimicrobial properties of Mg alloy-based implants covering both in vitro and in vivo studies. The strategies on hindering/overcoming the excessive inflammatory response and enhancing the antimicrobial activity are discussed in this review.
基金supported by the Universiti Kebangsaan Malaysia Research University Grant(GGPM-2020-037,MNS)the Natural Sciences and Engineering Research Council of Canada(RGPIN-2017-04274,HH).
文摘Magnesium alloys are considered the most suitable absorbable metals for bone fracture fixation implants.The main challenge in absorbable magnesium alloys is their high corrosion/degradation rate that needs to be controlled.Various coatings have been applied to magnesium alloys to slow down their corrosion rates to match their corrosion rate to the regeneration rate of the bone fracture.In this review,a bioactive coating is proposed to slow down the corrosion rate of magnesium alloys and accelerate the bone fracture healing process.The main aim of the bioactive coatings is to enhance the direct attachment of living tissues and thereby facilitate osteoconduction.Hydroxyapatite,collagen type I,recombinant human bone morphogenetic proteins 2,simvastatin,zoledronate,and strontium are six bioactive agents that show high potential for developing a bioactive coating system for high-performance absorbable magnesium bone implants.In addition to coating,the substrate itself can be made bioactive by alloying magnesium with calcium,zinc,copper,and manganese that were found to promote bone regeneration.
