In a recent study published in Cell,Ganz et al.shed new light on the mutational landscape of brain cells,particularly neurons and oligodendrocytes(OLs).1 Utilizing a combination of optimized single-cell whole-genome s...In a recent study published in Cell,Ganz et al.shed new light on the mutational landscape of brain cells,particularly neurons and oligodendrocytes(OLs).1 Utilizing a combination of optimized single-cell whole-genome sequencing with single-nucleus chromatin accessibility and gene expression analysis,they profiled somatic mutations in 86 OLs from 13 neurotypical individuals,spanning in age from infants to elderly.Neurons investigated were 56,derived from 19(including 12 overlapping)individuals(Fig.1).展开更多
基金supported by DZNE core funding,the Helmholtz-Gemeinschaft Innovation Pool,Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)under Germany’s Excellence Strategy XC2151-390873048CANTAR.The project“CANTAR”is receiving funding from the program“Netzwerke 2021,”an initiative of the Ministry of Culture and Science of the State of North Rhine-Westphalia.The sole responsibility for the content of this publication lies with the authors+3 种基金funding from the European Union’s Horizon Europe research and innovation program under the MSCA Doctoral Networks 2021,No.101072759(FuEl ThE bRaiN In healtThY aging and age-related diseases,ETERNITY)supported by DZNE core funding,a European Research Council Starting Grant(#101041677)Alzheimer’s Association Research Grant(AARG-19-616534)the project“InVirtuo 4.0”by the Ministry of Culture and Science of the State of North Rhine-Westphalia.
文摘In a recent study published in Cell,Ganz et al.shed new light on the mutational landscape of brain cells,particularly neurons and oligodendrocytes(OLs).1 Utilizing a combination of optimized single-cell whole-genome sequencing with single-nucleus chromatin accessibility and gene expression analysis,they profiled somatic mutations in 86 OLs from 13 neurotypical individuals,spanning in age from infants to elderly.Neurons investigated were 56,derived from 19(including 12 overlapping)individuals(Fig.1).
