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双氯灭痛控释片的处方和特性评价 被引量:1
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作者 S.P.Vyas n.k.jain 吴国兴 《药学进展》 CAS 北大核心 1990年第3期169-171,共3页
当亲水的水溶性基质接触水溶液后,就形成了一层假胶状膜,这层膜控制了片子的溶蚀和药物向周围液体扩散的速率。Willis及其同工作者测定了双氯灭痛静脉给药和口服给药的药物动力学。该药动力学的特性曲线提示,以控制药物吸收来达到延长周... 当亲水的水溶性基质接触水溶液后,就形成了一层假胶状膜,这层膜控制了片子的溶蚀和药物向周围液体扩散的速率。Willis及其同工作者测定了双氯灭痛静脉给药和口服给药的药物动力学。该药动力学的特性曲线提示,以控制药物吸收来达到延长周期,保证几乎是恒定的血药水平,并具有较小的毒副作用是有可能的。本文拟介绍双氯灭痛控释片的研究。方法为使双氯灭痛从控释片中释放达12h以上,应用Robinson和Eriksen方程,根据所报道的药动学数据计算其修正剂量和维持剂量分别为16.5mg和96.0mg. 展开更多
关键词 双氯灭痛 控释片 处方
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A Micro-Structure Dependent Buckling Analysis of Partially-Cracked Generally Orthotropic Plate under Thermal Domain
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作者 Ankur Gupta Shashank Soni n.k.jain 《Advances in Applied Mathematics and Mechanics》 SCIE 2023年第1期244-266,共23页
In this work,a non-classical analytical approach for buckling analysis of partially cracked generally orthotropic plate is proposed under the thermal domain.The derivation for the governing equation is based on the no... In this work,a non-classical analytical approach for buckling analysis of partially cracked generally orthotropic plate is proposed under the thermal domain.The derivation for the governing equation is based on the non-classical approach using Kirchhoff’s thin plate theory and the modified couple stress theory.The effect of fibre orientation on critical buckling temperature is incorporated by considering the coefficients of mutual influence.Line spring model is applied with some modifications to formulate all the crack terms while the thermal effects are introduced in form of thermal in-plane moments and forces.The final governing equation is solved using Galerkin’s method and the relation for critical buckling temperature as affected by fibre orientation is obtained.The variation of critical buckling temperature as affected by fibre orientation for different values of crack length,crack location and length scale parameter is presented.Also,the effect of fibre orientation on fundamental frequency under the thermal domain is analysed. 展开更多
关键词 Orthotropic plate fibre orientation CRACK microstructure thermal domain
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