Purpose: To investigate whether the mixed beta-blocker, metipranolol, possesses calcium and sodium channel blocking activities and blunts the effects of retinal ischaemia as reported for the betal-antagonist, betaxolo...Purpose: To investigate whether the mixed beta-blocker, metipranolol, possesses calcium and sodium channel blocking activities and blunts the effects of retinal ischaemia as reported for the betal-antagonist, betaxolol (Expt. Eye Research 1999, 69, 331-342). Methods: Rat retinas or rat brain synaptosomes were exposed to radioactive calcium or sodium and NM-展开更多
Retinal photoreceptors and the retinal pigment epithelium contains particularly high amount of free zinc. Free zinc is also associated with the neuronal retina but at lower amounts where it is thought to participate i...Retinal photoreceptors and the retinal pigment epithelium contains particularly high amount of free zinc. Free zinc is also associated with the neuronal retina but at lower amounts where it is thought to participate in a number of functions, including being a neuromodulator. In the studies conducted we now provide experimental evidence to show that zinc is a key mediator and modulator of neuronal death in the retina. For example, physio-展开更多
文摘Purpose: To investigate whether the mixed beta-blocker, metipranolol, possesses calcium and sodium channel blocking activities and blunts the effects of retinal ischaemia as reported for the betal-antagonist, betaxolol (Expt. Eye Research 1999, 69, 331-342). Methods: Rat retinas or rat brain synaptosomes were exposed to radioactive calcium or sodium and NM-
文摘Retinal photoreceptors and the retinal pigment epithelium contains particularly high amount of free zinc. Free zinc is also associated with the neuronal retina but at lower amounts where it is thought to participate in a number of functions, including being a neuromodulator. In the studies conducted we now provide experimental evidence to show that zinc is a key mediator and modulator of neuronal death in the retina. For example, physio-
