目的探索脑小血管病(cerebral small vessel disease,CSVD)总负荷与记忆力下降老年患者认知功能、脑萎缩及脑灌注的关系。方法回顾性纳入2015年12月-2017年12月同济医院神经内科门诊及记忆减退专病门诊主诉记忆力下降患者,收集一般资料...目的探索脑小血管病(cerebral small vessel disease,CSVD)总负荷与记忆力下降老年患者认知功能、脑萎缩及脑灌注的关系。方法回顾性纳入2015年12月-2017年12月同济医院神经内科门诊及记忆减退专病门诊主诉记忆力下降患者,收集一般资料及影像学信息,进行认知评估、CSVD总负荷评分、全脑及各脑叶脑萎缩评分,计算脑血流(cerebralbloodflow,CBF)值。采用Spearman相关分析CSVD总负荷评分与认知功能、脑萎缩及CBF的关系。结果共纳入200例,平均年龄69.16±9.44岁,男性99例(49.5%)。CSVD总负荷与MoCA评分呈负相关(r=-0.202,P=0.004);与全脑(r=-0.234,P=0.001)、额叶(r=-0.252,P<0.001)、顶叶(r=-0.253,P<0.001)、枕叶(r=-0.224,P=0.001)CBF呈负相关;CSVD负荷与全脑(r=0.313,P<0.001)、额叶(r=0.393,P<0.001)及顶叶(r=0.237,P=0.001)的脑萎缩评分呈正相关。结论CSVD总负荷越高,认知功能越差、脑灌注越低、脑萎缩越严重。展开更多
Objective:To examine whether the combination of Naoxintong Capsule with standard care could further reduce the recurrence of ischemic stroke without increasing the risk of severe bleeding.Methods:A total of 23 Chinese...Objective:To examine whether the combination of Naoxintong Capsule with standard care could further reduce the recurrence of ischemic stroke without increasing the risk of severe bleeding.Methods:A total of 23 Chinese medical centers participated in this trial.Adult patients with a history of ischemic stroke were randomlyassigned ina 1:1ratiousing a blockdesign toreceive eitherNaoxintong Capsule(1.2gorally,twice a day)or placebo in addition to standard care.The primary endpoint was recurrence of ischemic stroke within 2 years.Secondary outcomes included myocardial infarction,death due to recurrent ischemic stroke,and all-cause mortality.The safety of drugs was monitored.Results were analyzed using the intention-to-treat principle.展开更多
Background Standardized screening tools for Parkinson syndrome have not been developed for non-westem populations. This study aimed to validate the Copiah County questionnaire （CCQ） as a screening instrument in a Ch...Background Standardized screening tools for Parkinson syndrome have not been developed for non-westem populations. This study aimed to validate the Copiah County questionnaire （CCQ） as a screening instrument in a Chinese rural population. Methods All participants of a previously reported prevalent study were interviewed using CCQ. The participants who answered yes to at least one item on CCQ were defined as positive. The Parkinson＇s disease （PD） diagnosis was established using United Kingdom Parkinson＇s disease Brain Bank Clinical diagnosis criteria （UKPDBBC） and served as a gold standard to determine the sensitivity, specificity, and positive and negative predictive values （PPV, NPV） for the questionnaire. Results Among 16 130 participants, 2872 （17.8%） were screened positive for CCQ and 13 258 negative （82.2%）. Among the 697 participants diagnosed as having Parkinson syndrome, 605 were positive for CCQ, and 92 were negative, leading to a sensitivity of 86.8%. Out of the 15 433 non-Parkinson syndrome participants, 13 166 were negative to CCQ, giving a specificity of 85.3%. Among the 2872 participants screened positive, 605 were diagnosed with Parkinson syndrome, and their PPV was 21.1%. For the 13 258 participants screened negative on CCQ, 92 were diagnosed with Parkinson syndrome and 13 166 did not have Parkinson syndrome, leading to a NPV of 99.3%. Conclusions CCQ appeared to have satisfactory statistical parameters to serve as a screening instrument for Parkinson syndrome in this rural Chinese population. Further studies may prove the utility of this short questionnaire in Parkinson syndrome screening among Chinese populations including those residing in rural areas.展开更多
文摘目的探索脑小血管病(cerebral small vessel disease,CSVD)总负荷与记忆力下降老年患者认知功能、脑萎缩及脑灌注的关系。方法回顾性纳入2015年12月-2017年12月同济医院神经内科门诊及记忆减退专病门诊主诉记忆力下降患者,收集一般资料及影像学信息,进行认知评估、CSVD总负荷评分、全脑及各脑叶脑萎缩评分,计算脑血流(cerebralbloodflow,CBF)值。采用Spearman相关分析CSVD总负荷评分与认知功能、脑萎缩及CBF的关系。结果共纳入200例,平均年龄69.16±9.44岁,男性99例(49.5%)。CSVD总负荷与MoCA评分呈负相关(r=-0.202,P=0.004);与全脑(r=-0.234,P=0.001)、额叶(r=-0.252,P<0.001)、顶叶(r=-0.253,P<0.001)、枕叶(r=-0.224,P=0.001)CBF呈负相关;CSVD负荷与全脑(r=0.313,P<0.001)、额叶(r=0.393,P<0.001)及顶叶(r=0.237,P=0.001)的脑萎缩评分呈正相关。结论CSVD总负荷越高,认知功能越差、脑灌注越低、脑萎缩越严重。
基金Supported by the Shanghai Municipal Commission of Science and Technology,China(No.STCSM 14401970300)。
文摘Objective:To examine whether the combination of Naoxintong Capsule with standard care could further reduce the recurrence of ischemic stroke without increasing the risk of severe bleeding.Methods:A total of 23 Chinese medical centers participated in this trial.Adult patients with a history of ischemic stroke were randomlyassigned ina 1:1ratiousing a blockdesign toreceive eitherNaoxintong Capsule(1.2gorally,twice a day)or placebo in addition to standard care.The primary endpoint was recurrence of ischemic stroke within 2 years.Secondary outcomes included myocardial infarction,death due to recurrent ischemic stroke,and all-cause mortality.The safety of drugs was monitored.Results were analyzed using the intention-to-treat principle.
文摘Background Standardized screening tools for Parkinson syndrome have not been developed for non-westem populations. This study aimed to validate the Copiah County questionnaire （CCQ） as a screening instrument in a Chinese rural population. Methods All participants of a previously reported prevalent study were interviewed using CCQ. The participants who answered yes to at least one item on CCQ were defined as positive. The Parkinson＇s disease （PD） diagnosis was established using United Kingdom Parkinson＇s disease Brain Bank Clinical diagnosis criteria （UKPDBBC） and served as a gold standard to determine the sensitivity, specificity, and positive and negative predictive values （PPV, NPV） for the questionnaire. Results Among 16 130 participants, 2872 （17.8%） were screened positive for CCQ and 13 258 negative （82.2%）. Among the 697 participants diagnosed as having Parkinson syndrome, 605 were positive for CCQ, and 92 were negative, leading to a sensitivity of 86.8%. Out of the 15 433 non-Parkinson syndrome participants, 13 166 were negative to CCQ, giving a specificity of 85.3%. Among the 2872 participants screened positive, 605 were diagnosed with Parkinson syndrome, and their PPV was 21.1%. For the 13 258 participants screened negative on CCQ, 92 were diagnosed with Parkinson syndrome and 13 166 did not have Parkinson syndrome, leading to a NPV of 99.3%. Conclusions CCQ appeared to have satisfactory statistical parameters to serve as a screening instrument for Parkinson syndrome in this rural Chinese population. Further studies may prove the utility of this short questionnaire in Parkinson syndrome screening among Chinese populations including those residing in rural areas.
