Objectives: Auditory neuropathy (AN) is a sensorineural hearing disorder characterized by absent or abnormal auditory brainstem responses (ABRs) and normal cochlear outer hair cell function as measured by otoacoustic ...Objectives: Auditory neuropathy (AN) is a sensorineural hearing disorder characterized by absent or abnormal auditory brainstem responses (ABRs) and normal cochlear outer hair cell function as measured by otoacoustic emissions (OAEs). Many risk factors are thought to be involved in its etiology and pathophysiology. Three Chinese pedigrees with familial AN are presented herein to demonstrate involvement of genetic factors in AN etiology. Methods: Probands of the above - mentioned pedigrees, who had been diagnosed with AN, were evaluated and followed up in the Department of Otolaryngology Head and Neck Surgery, China PLA General Hospital. Their family members were studied and the pedigree diagrams were established. History of illness, physical examination,pure tone audiometry, acoustic reflex, ABRs and transient evoked and distortion- product otoacoustic emissions (TEOAEs and DPOAEs) were obtained from members of these families. DPOAE changes under the influence of contralateral sound stimuli were observed by presenting a set of continuous white noise to the non - recording ear to exam the function of auditory efferent system. Some subjects received vestibular caloric test, computed tomography (CT)scan of the temporal bone and electrocardiography (ECG) to exclude other possible neuropathy disorders. Results: In most affected subjects, hearing loss of various degrees and speech discrimination difficulties started at 10 to16 years of age. Their audiological evaluation showed absence of acoustic reflex and ABRs. As expected in AN, these subjects exhibited near normal cochlear outer hair cell function as shown in TEOAE & DPOAE recordings. Pure- tone audiometry revealed hearing loss ranging from mild to severe in these patients. Autosomal recessive inheritance patterns were observed in the three families. In Pedigree Ⅰ and Ⅱ, two affected brothers were found respectively, while in pedigree Ⅲ, 2 sisters were affected. All the patients were otherwise normal without evidence of peripheral neuropathy at the time of this writing. Conclusions: In this study, patients with feature of non- syndromic hereditary auditory neuropathy were identified in three Chinese families.Pedigree analysis indicates autosomal recessive inheritances in the pedigrees. The observed inheritance and clinical audiologic findings are different from those previously described for non-syndromic low-frequency sensorineural hearing loss. This information should facilitate future molecular candidate genes screening for understanding the mechanism of AN.展开更多
The Pd-B/g-Al2O3 amorphous alloy catalyst and Pd/g-Al2O3 crystalline metal catalyst were prepared by KBH4 reduction and routine impregnation, respectively. Pd-B/g-Al2O3 and Pd/g-Al2O3 catalysts were characterized by ...The Pd-B/g-Al2O3 amorphous alloy catalyst and Pd/g-Al2O3 crystalline metal catalyst were prepared by KBH4 reduction and routine impregnation, respectively. Pd-B/g-Al2O3 and Pd/g-Al2O3 catalysts were characterized by XRD and SEM. It was found that the catalytic activity of the Pd-B/g-Al2O3 amorphous alloy catalyst was higher than that of the Pd/g-Al2O3 crystalline metal catalyst in the anthraquinone hydrogenation.展开更多
The method to synthesize a high affinity muscarinic receptor antagonist (R,S)I-QNB[(R)-(-)-1-azabicyclo [2,2,2]oct-3-yl-(S)-(+)-α-hydroxy-α-(4-[127I]iodophenyl)-α-phenyl acetate] from 4-nitrobenzophenone with impro...The method to synthesize a high affinity muscarinic receptor antagonist (R,S)I-QNB[(R)-(-)-1-azabicyclo [2,2,2]oct-3-yl-(S)-(+)-α-hydroxy-α-(4-[127I]iodophenyl)-α-phenyl acetate] from 4-nitrobenzophenone with improvement compared to literatures was reported in this article. IR, MS and 1HNMR characterized the final product. (R,S)131I-QNB was prepared using Cu(I) assisted iodine exchange labeling, and showed by TLC that the radiolabeling yield(RLY) was over 80%, and radiochemical purity(RCP) was over 95%. Stability of the labeled compound was also determined. It was found that (R,S)131I-QNB dried by nitrogen blowing can stay at 4-10℃ for a week without change of RCP.展开更多
The authors present a routing lookup architecture, SDIR(SDRAM based Direct Index Routing). With pipeline and interleaving access technique, SDIR can provide scalable lookup speed from 16 7 MPPS(mega packet per second)...The authors present a routing lookup architecture, SDIR(SDRAM based Direct Index Routing). With pipeline and interleaving access technique, SDIR can provide scalable lookup speed from 16 7 MPPS(mega packet per second) to 133 MPPS with SDRAM running at 133MHz frequency.展开更多
Bamei is a village hidden inremote mountains of Yun’nan Province.The only way ofgetting to this hidden treasureis to take a boat through the dark cave atthe end of which there is a bright worldfull of peace and beaut...Bamei is a village hidden inremote mountains of Yun’nan Province.The only way ofgetting to this hidden treasureis to take a boat through the dark cave atthe end of which there is a bright worldfull of peace and beauty.Anyone seeingphotos of the entrance to this amazingworld will surely be attracted.So was I.展开更多
To mark the 40th anniversary of the signing of the Sino-Japanese Peace and Friendship Treaty, Japan’s Eisei Bunko Museum donated4,175 ancient Chinese books to the National Library of China on Tuesday. Guests and offi...To mark the 40th anniversary of the signing of the Sino-Japanese Peace and Friendship Treaty, Japan’s Eisei Bunko Museum donated4,175 ancient Chinese books to the National Library of China on Tuesday. Guests and officials from both countries attended the donation ceremony at the National Museum of Classic Books in Beijing.展开更多
基金a grant from the National High Tech Development Project(2001AA221092)and by Beijing Natural Science Foundation(No.7011004)and Beijing Science and Technology Innovation Project(No.H010210160119)grants
文摘Objectives: Auditory neuropathy (AN) is a sensorineural hearing disorder characterized by absent or abnormal auditory brainstem responses (ABRs) and normal cochlear outer hair cell function as measured by otoacoustic emissions (OAEs). Many risk factors are thought to be involved in its etiology and pathophysiology. Three Chinese pedigrees with familial AN are presented herein to demonstrate involvement of genetic factors in AN etiology. Methods: Probands of the above - mentioned pedigrees, who had been diagnosed with AN, were evaluated and followed up in the Department of Otolaryngology Head and Neck Surgery, China PLA General Hospital. Their family members were studied and the pedigree diagrams were established. History of illness, physical examination,pure tone audiometry, acoustic reflex, ABRs and transient evoked and distortion- product otoacoustic emissions (TEOAEs and DPOAEs) were obtained from members of these families. DPOAE changes under the influence of contralateral sound stimuli were observed by presenting a set of continuous white noise to the non - recording ear to exam the function of auditory efferent system. Some subjects received vestibular caloric test, computed tomography (CT)scan of the temporal bone and electrocardiography (ECG) to exclude other possible neuropathy disorders. Results: In most affected subjects, hearing loss of various degrees and speech discrimination difficulties started at 10 to16 years of age. Their audiological evaluation showed absence of acoustic reflex and ABRs. As expected in AN, these subjects exhibited near normal cochlear outer hair cell function as shown in TEOAE & DPOAE recordings. Pure- tone audiometry revealed hearing loss ranging from mild to severe in these patients. Autosomal recessive inheritance patterns were observed in the three families. In Pedigree Ⅰ and Ⅱ, two affected brothers were found respectively, while in pedigree Ⅲ, 2 sisters were affected. All the patients were otherwise normal without evidence of peripheral neuropathy at the time of this writing. Conclusions: In this study, patients with feature of non- syndromic hereditary auditory neuropathy were identified in three Chinese families.Pedigree analysis indicates autosomal recessive inheritances in the pedigrees. The observed inheritance and clinical audiologic findings are different from those previously described for non-syndromic low-frequency sensorineural hearing loss. This information should facilitate future molecular candidate genes screening for understanding the mechanism of AN.
文摘The Pd-B/g-Al2O3 amorphous alloy catalyst and Pd/g-Al2O3 crystalline metal catalyst were prepared by KBH4 reduction and routine impregnation, respectively. Pd-B/g-Al2O3 and Pd/g-Al2O3 catalysts were characterized by XRD and SEM. It was found that the catalytic activity of the Pd-B/g-Al2O3 amorphous alloy catalyst was higher than that of the Pd/g-Al2O3 crystalline metal catalyst in the anthraquinone hydrogenation.
基金Foundation for Outstanding Young Members of Health Ministry in China(9925)
文摘The method to synthesize a high affinity muscarinic receptor antagonist (R,S)I-QNB[(R)-(-)-1-azabicyclo [2,2,2]oct-3-yl-(S)-(+)-α-hydroxy-α-(4-[127I]iodophenyl)-α-phenyl acetate] from 4-nitrobenzophenone with improvement compared to literatures was reported in this article. IR, MS and 1HNMR characterized the final product. (R,S)131I-QNB was prepared using Cu(I) assisted iodine exchange labeling, and showed by TLC that the radiolabeling yield(RLY) was over 80%, and radiochemical purity(RCP) was over 95%. Stability of the labeled compound was also determined. It was found that (R,S)131I-QNB dried by nitrogen blowing can stay at 4-10℃ for a week without change of RCP.
文摘The authors present a routing lookup architecture, SDIR(SDRAM based Direct Index Routing). With pipeline and interleaving access technique, SDIR can provide scalable lookup speed from 16 7 MPPS(mega packet per second) to 133 MPPS with SDRAM running at 133MHz frequency.
文摘Bamei is a village hidden inremote mountains of Yun’nan Province.The only way ofgetting to this hidden treasureis to take a boat through the dark cave atthe end of which there is a bright worldfull of peace and beauty.Anyone seeingphotos of the entrance to this amazingworld will surely be attracted.So was I.
文摘To mark the 40th anniversary of the signing of the Sino-Japanese Peace and Friendship Treaty, Japan’s Eisei Bunko Museum donated4,175 ancient Chinese books to the National Library of China on Tuesday. Guests and officials from both countries attended the donation ceremony at the National Museum of Classic Books in Beijing.
