血小板衍生生长因子BB参与生长板损伤修复的作用与机制

背景:在生长板损伤炎症初期,血小板衍生生长因子BB通过促进间充质祖细胞浸润、软骨形成、成骨反应以及调控骨重塑来促进生长板损伤的修复。目的:总结血小板衍生生长因子BB在生长板损伤修复中的作用机制。方法:检索PubMed、维普、万方数据和中国知网数据库,中文检索词为“生长板损伤,骨桥形成,血小板衍生因子BB,修复”,英文检索词为“growth plate injury,bone bridge,PDGF-BB,repair”,最终筛选66篇文章进行综述。结果与结论:生长板损伤经历早期炎症、血管重建、纤维骨化、结构重塑等病理进程,伴随着软骨细胞、血管内皮细胞、干细胞、成骨细胞、破骨细胞多种细胞交叉对话。血小板衍生生长因子BB作为损伤早期炎症反应的重要因子通过介导多种细胞炎症反应调控损伤修复过程,靶向血小板衍生生长因子BB介导的炎症刺激可能通过改善破骨细胞、成骨细胞、软骨细胞功能活性延缓生长板损伤骨桥形成进程,实现生长板损伤修复。血小板衍生生长因子BB对生长板损伤部位的血管生成和骨修复组织形成以及未损伤生长板的软骨内骨延长功能具有重要作用,抑制血小板衍生生长因子BB启动的血管形成与软骨内成骨之间的偶联效应将有可能实现生长板损伤修复。

基于深度卷积自编码器的微波成像方法及其医学应用潜力

开发一个基于深度学习的微波成像模型,将散射电场直接映射为目标物体介电特性分布图像,并探索其在医学应用的潜在价值。采用二维时域有限差分法进行数值模拟来获取散射电场数据集;构建基于深度卷积自编码器成像模型,对两类目标物体进行成像研究;使用相对误差进行成像结果的定量评估,并分析成像模型对不同卒中类型的区分能力。结果表明基于深度卷积自编码器的成像网络在处理两种数值模型时均展现出色的成像性能。对于简单物体,该模型能准确定位并初步重建物体形状,平均相对误差为0.3012;对于卒中模型,能较好地重建卒中区域的位置和形状,初步重建其他脑组织,平均相对误差为0.0778。基于深度卷积自编码器的微波成像网络对快速准确重建图像很有前景,脑卒中检测的数值示例表明该方法在生物医学成像领域具有显著的应用潜力。

Study on structural characteristics and adsorption performance of ultrasonic treated Mn-containing sulfur transfer agent

To prepare manganese-containing spinel sulfur transfer agent with acid peptization, ultrasonic wave is used for the first time to modify the structure of sulfur transfer agent in this work. Mini fixed bed reactor was used to investigate the effect of ultrasonic power, time and temperature on the structure and oxidation adsorption performance of sulfur transfer agent and the adsorption kinetics and mechanism of SO2 were analyzed. SEM, TEM, XRD and N2 adsorption-desorption techniques were employed to characterize and analyse the function of sulfur transfer agent. The results indicated that manganese-containing spinel is a kind of promising sulfur transfer agent and exhibits higher sulfur capacity and desulfurization degree under the selected conditions of the ultrasonic wave power of 60%, and with the treatment period for 3 h at a temperature of 60 ℃.

Linked color imaging vs Lugol chromoendoscopy for esophageal squamous cell cancer and precancerous lesion screening: A noninferiority study

BACKGROUND Lugol chromoendoscopy(LCE)has served as a standard screening technique in high-risk patients with esophageal cancer.Nevertheless,LCE is not suitable for general population screening given its side effects.Linked color imaging(LCI)is a novel image-enhanced endoscopic technique that can distinguish subtle differences in mucosal color.AIM To compare the diagnostic performance of LCI with LCE in detecting esophageal squamous cell cancer and precancerous lesions and to evaluate whether LCE can be replaced by LCI in detecting esophageal neoplastic lesions.METHODS In this prospective study,we enrolled 543 patients who underwent white light imaging(WLI),LCI and LCE successively.We compared the sensitivity and specificity of LCI and LCE in the detection of esophageal neoplastic lesions.Clinicopathological features and color analysis of lesions were assessed.RESULTS In total,43 patients(45 neoplastic lesions)were analyzed.Among them,36 patients(38 neoplastic lesions)were diagnosed with LCI,and 39 patients(41 neoplastic lesions)were diagnosed with LCE.The sensitivity of LCI was similar to that of LCE(83.7%vs 90.7%,P=0.520),whereas the specificity of LCI was greater than that of LCE(92.4%vs 87.0%,P=0.007).The LCI procedure time in the esophageal examination was significantly shorter than that of LCE[42(34,50)s vs 160(130,189)s,P<0.001].The color difference between the lesion and surrounding mucosa in LCI was significantly greater than that observed with WLI.However,the color difference in LCI was similar in different pathological types of esophageal squamous cell cancer.CONCLUSION LCI offers greater specificity than LCE in the detection of esophageal squamous cell cancer and precancerous lesions,and LCI represents a promising screening strategy for general populations.

基于EPSTI1表达的临床病理特征列线图预测肾透明细胞癌预后

目的:构建基于上皮间质相互作用蛋白1(epithelial-stromal interaction protein 1,EPSTI1)预后列线图预测肾透明细胞癌的预后。方法:回顾性分析2012年1月至2015年12月于福建医科大学附属第一医院221例接受手术治疗的肾透明细胞癌患者和TCGA数据库中533例肾透明细胞癌患者数据,对癌旁正常组织和癌组织标本进行免疫组织化学(immunohistochemistry,IHC)染色,分析EPSTI1的表达差异及与临床病理特征的相关性。对EPSTI1高表达与低表达患者的总生存期(overall survival,OS)和无病生存期(disease-free survival,DFS)进行Kaplan-Meier生存分析,采用单因素和多因素Cox比例风险模型分析OS的预后因素,进一步构建列线图模型并验证。结果:与癌旁正常肾组织比较,肾透明细胞癌组织中EPSTI1的IHC评分和m RNA表达水平均显著高于正常组织(均P<0.001),且在高T分期的癌组织中表达更高(P=0.036,P=0.006);EPSTI1蛋白表达与肿瘤最大径、TNM分期相关(P=0.002,P=0.032);EPSTI1低表达组OS、DFS均优于高表达组(P=0.046,P=0.003,P=0.001);单因素和多因素Cox回归分析结果显示,EPSTI1蛋白高表达、WHO/ISUP分级、AJCC/TNM分期是影响肾透明细胞癌患者预后不良的独立危险因素(P=0.009,P=0.039,P<0.001);基于上述变量构建的预后列线图模型对患者5年OS预测能力优于AJCC/TNM分期,校准曲线显示模型预测值与实际值间具有良好的一致性。结论:基于EPSTI1、AJCC/TNM分期和WHO/ISUP分级建立的列线图模型对肾透明细胞癌预后具有较强的预测能力。

Comparative transcriptome analysis between rhesus macaques(Macaca mulatta) and crab-eating macaques(M. fascicularis)

Understanding gene expression variations between species is pivotal for deciphering the evolutionary diversity in phenotypes. Rhesus macaques(Macaca mulatta, MMU)and crab-eating macaques(M. fascicularis, MFA) serve as crucial nonhuman primate biomedical models with different phenotypes. To date, however, large-scale comparative transcriptome research between these two species has not yet been fully explored. Here, we conducted systematic comparisons utilizing newly sequenced RNA-seq data from84 samples(41 MFA samples and 43 MMU samples)encompassing 14 common tissues. Our findings revealed a small fraction of genes(3.7%) with differential expression between the two species, as well as 36.5% of genes with tissue-specific expression in both macaques. Comparison of gene expression between macaques and humans indicated that 22.6% of orthologous genes displayed differential expression in at least two tissues. Moreover,19.41% of genes that overlapped with macaque-specific structural variants showed differential expression between humans and macaques. Of these, the FAM220A gene exhibited elevated expression in humans compared to macaques due to lineage-specific duplication. In summary,this study presents a large-scale transcriptomic comparison between MMU and MFA and between macaques and humans. The discovery of gene expression variations not only enhances the biomedical utility of macaque models but also contributes to the wider field of primate genomics.

Microstructures and micromechanical behaviors of high -entropy alloys investigated by synchrotron X-ray and neutron diffraction techniques: A review

High-entropy alloys(HEAs)possess outstanding features such as corrosion resistance,irradiation resistance,and good mechan-ical properties.A few HEAs have found applications in the fields of aerospace and defense.Extensive studies on the deformation mech-anisms of HEAs can guide microstructure control and toughness design,which is vital for understanding and studying state-of-the-art structural materials.Synchrotron X-ray and neutron diffraction are necessary techniques for materials science research,especially for in situ coupling of physical/chemical fields and for resolving macro/microcrystallographic information on materials.Recently,several re-searchers have applied synchrotron X-ray and neutron diffraction methods to study the deformation mechanisms,phase transformations,stress behaviors,and in situ processes of HEAs,such as variable-temperature,high-pressure,and hydrogenation processes.In this review,the principles and development of synchrotron X-ray and neutron diffraction are presented,and their applications in the deformation mechanisms of HEAs are discussed.The factors that influence the deformation mechanisms of HEAs are also outlined.This review fo-cuses on the microstructures and micromechanical behaviors during tension/compression or creep/fatigue deformation and the application of synchrotron X-ray and neutron diffraction methods to the characterization of dislocations,stacking faults,twins,phases,and intergrain/interphase stress changes.Perspectives on future developments of synchrotron X-ray and neutron diffraction and on research directions on the deformation mechanisms of novel metals are discussed.

Lipid metabolism-related long noncoding RNA RP11-817I4.1 promotes fatty acid synthesis and tumor progression in hepatocellular carcinoma

BACKGROUND Hepatocellular carcinoma(HCC)is one of the most common types of tumors.The influence of lipid metabolism disruption on the development of HCC has been demonstrated in published studies.AIM To establish an HCC prognostic model for lipid metabolism-related long non-coding RNAs(LMR-lncRNAs)and conduct in-depth research on the specific role of novel LMR-lncRNAs in HCC.METHODS Correlation and differential expression analyses of The Cancer Genome Atlas data were used to identify differentially expressed LMR-lncRNAs.Quantitative real-time polymerase chain reaction analysis was used to evaluate the expression of LMR-lncRNAs.Nile red staining was employed to observe intracellular lipid levels.The interaction between RP11-817I4.1,miR-3120-3p,and ATP citrate lyase(ACLY)was validated through the performance of dual-luciferase reporter gene and RIP assays.RESULTS Three LMR-lncRNAs(negative regulator of antiviral response,RNA transmembrane and coiled-coil domain family 1 antisense RNA 1,and RP11-817I4.1)were identified as predictive markers for HCC patients and were utilized in the construction of risk models.Additionally,proliferation,migration,and invasion were reduced by RP11-817I4.1 knockdown.An increase in lipid levels in HCC cells was significantly induced by RP11-817I4.1 through the miR-3120-3p/ACLY axis.CONCLUSION LMR-lncRNAs have the capacity to predict the clinical characteristics and prognoses of HCC patients,and the discovery of a novel LMR-lncRNAs,RP11-817I4.1,revealed its role in promoting lipid accumulation,thereby accelerating the onset and progression of HCC.

Comparison of Microwave Imaging Algorithms for Short-Range Scenarios

Three dimensional(3-D)imaging algorithms with irregular planar multiple-input-multiple-output(MIMO)arrays are discussed and compared with each other.Based on the same MIMO array,a modified back projection algorithm(MBPA)is accordingly proposed and four imaging algorithms are used for comparison,back-projection method(BP),back-projection one in time domain(BP-TD),modified back-projection one and fast Fourier transform(FFT)-based MIMO range migration algorithm(FFT-based MIMO RMA).All of the algorithms have been implemented in practical application scenarios by use of the proposed imaging system.Back to the practical applications,MIMO array-based imaging system with wide-bandwidth properties provides an efficient tool to detect objects hidden behind a wall.An MIMO imaging radar system,composed of a vector network analyzer(VNA),a set of switches,and an array of Vivaldi antennas,have been designed,fabricated,and tested.Then,these algorithms have been applied to measured data collected in different scenarios constituted by five metallic spheres in the absence and in the presence of a wall between the antennas and the targets in simulation and pliers in free space for experimental test.Finally,the focusing properties and time consumption of the above algorithms are compared.

椎间盘退行性变的机制及治疗方案研究进展

椎间盘退行性变(intervertebral disc degeneration,IDD)是多种慢性脊椎疾病的主要致病因素,其主要临床症状包括下腰痛和急性下肢神经根性疼痛。近年来,随着人口老龄化进展加速及生活方式改变,IDD的发病率显著上升且呈现年轻化趋势,严重影响了患者的生活质量,并给社会带来了巨大的经济和医疗负担。如何有效防治IDD已成为当前亟待解决的医学难题。现有研究表明,椎间盘细胞衰老在IDD的发生与进展中扮演着重要角色,靶向衰老椎间盘细胞的治疗策略,如抗细胞衰老药物、基因编辑及干细胞疗法等,正逐渐成为研究热点。该文综述了椎间盘细胞衰老的分子机制,阐述了针对衰老细胞的多种治疗策略及最新进展,旨在为IDD的防治提供新的研究思路和治疗靶点,并为后续研究提供参考。

Network Pharmacological Analysis of Action Mechanism of Mongolian Medicine Rhododendron micranthum Turcz. in Treating Lung Cancer

[Objectives]To explore the action mechanism of Mongolian medicine Rhododendron micranthum Turcz.on lung cancer by network pharmacology.[Methods]Based on the high-throughput experiment and reference database(HERB)of traditional Chinese medicine,component target database(Swiss ADME),small molecule drug target prediction online platform(SWISS Target Prediction),human gene business card database(GENECARD),the database of genes and mutation sites related to human diseases(DISGENET)and other databases,the target genes of drugs and diseases were screened out.Venny software was used for obtaining the target intersection of active components of the Mongolian medicine R.micranthum Turcz.and the lung cancer,a CytoNCA plug-in in cytoscape 3.10.0 software was used for screening candidate core target genes,and related effective components were obtained in a reverse direction.A drug-active ingredient-gene-disease regulation network was established,a protein-protein interaction(PPI)network was established by means of the STRING database to screen core genes,and common targets were screened by the David database.Gene Ontology(GO)function and Kyoto Encyclopedia of Genes and Genomes(KEGG)were used for enrichment analysis.[Results]There were 13 effective components of Mongolian medicine R.micranthum Turcz.for treating lung cancer and 115 drug disease intersection target genes.Core genes affecting the disease included SRC,HSP90AB1,EGFR,AKT1,and ERBB2.GO functional enrichment analysis involved 462 items of biological processes,64 items of cellular components and 126 items of molecular functions.Enrichment analysis of KEGG signaling pathways screened out cancer pathways,endocrine resistance,PI3K-Akt signaling pathways,proteoglycans in cancer and other signaling pathways.[Conclusions]Mongolian medicine R.micranthum Turcz.can inhibit the proliferation of lung cancer cells from multiple targets and pathways,and the results of network pharmaceutical analysis provide a theoretical basis for further experimental research.

模拟电子技术课程设计课程AOT教学模式的改革及实践

目的:结合陆军军医大学模拟电子技术课程设计课程的特点,开展该课程AOT教学模式改革及实践。方法:结合AOT教学模式和模拟电子技术基础课程的特点,从教学内容、教学方法和过程评价等进行教学模式改革与实践,以满足部队卫勤保障和社会需求。实践结果:AOT教学模式调动了学员的学习热情,增强了学习效果,使学员更好地掌握理论知识。结论:AOT教学模式符合生物医学工程专业教学要求,可以有效提高教学质量。

CIK细胞治疗老年人中晚期胃癌的副反应分析

目的:探讨使用细胞因子诱导的杀伤细胞(cytokine-induced killer cells,CIK细胞)免疫治疗老年中晚期胃癌的副反应及其处理方法。方法:采用生物技术诱导培养CIK细胞,经培养后的CIK细胞回输给老年中晚期胃癌患者,同时观察输注后的临床反应。结果:在回输后29例老年中晚期胃癌患者中PR 8例,MR 9例,sD 7例,PD 5例,总缓解率为58．6％。患者的全身反应及局部反应包括寒战13例,发热9例,恶心呕吐1例,全身不适3例,经对症处理后无一例患者出现休克、毛细血管渗漏综合征、皮疹与血尿常规、肝肾功能异常。结论:用自体CIK细胞治疗老年中晚期胃癌,可使老年中晚期胃癌患者的临床症状和体征得到改善,治疗中的副反应经对症处理可以缓解。

Evaluation of Prognosis of Brain Function with Early Transcranial Color Doppler Ultrasound in Patients after Cardiopulmonary Resuscitation

Objective: To evaluate the clinical value of transcranial color Doppler ultrasound (TCCD) in assessing cerebral function after cardiopulmonary resuscitation (CPR). Methods: A prospective study was conducted in 52 patients with cardiac arrest treated by CPR from January 2018 to January 2020, and its clinical data were analyzed. According to classification of cerebral performance category (CPC), 31 cases (CPC grade 1 - 2) were selected in the good prognosis group and 21 cases (CPC grade 3 - 5) in the poor prognosis group. The cerebral blood flow was measured by transcranial Doppler ultrasound (TCCD) 24 h after CPR, and the differences were compared between the two groups in stroke index, diastolic blood flow velocity (Vd), systolic peak blood flow velocity (Vs) and mean peak blood flow velocity (Vm). The ROC curve of cerebral blood flow after CPR was drawn to predict the prognosis of brain function. Results: The data showed that the pulsatility index of middle cerebral artery of the poor prognosis group decreased within 24 h;the difference between the two groups was statistically significant (p < 0.05);the Vd, Vs, Vm increased in the good prognosis group;the difference between the two groups was statistically significant (p < 0.05). The ROC curve of cerebral blood flow after CPR was drawn to predict the prognosis of brain function, and the results showed that the area under the curve and the optimal critical value of cerebral blood flow were 0.731 and 5.69. The sensitivity and specificity were 67.3% and 79.1% respectively. Conclusion: The cerebral blood flow increase in the early stage of successful CPR is positively correlated with the prognosis of cerebral functional resuscitation. Monitoring intracranial blood flow after CPR by TCCD has clinical value to evaluate prognosis of brain function.

输灰系统流场优化与节能降耗关键技术研究

输灰系统是燃煤发电厂中重要的环保设备,其流场优化与节能降耗是当前研究的热点问题。文章分析了输灰系统的流场特性,探索了输灰系统流场优化的关键技术,并对流场优化后的节能降耗效果进行了评估,提出了输灰系统流场优化的实施方案。研究结果表明,流场优化技术能够显著降低能耗,提高输灰效率。

协同烟羽治理烟气余热利用系统的节能分析

为控制烟囱冒白烟现象的发生,某330MW机组配备有冷凝-再热烟羽治理系统,系统包含烟气冷却器、烟气加热器和烟气冷凝器,成为纯环保设备。根据投运后系统运行特点和烟羽治理效果需求,为实现节能降耗,系统进行了协同余热利用改造。改造内容包括:(1)新增板式换热器A,用于非供暖期烟气冷却器出口热媒水和低加系统凝结水换热;(2)新增板式换热器B,用于供暖期烟气冷却器出口热媒水与供暖回水换热;(3)新增板式换热器C,用于供暖期冷凝器出口循环冷却水与供暖水补水换热。板式换热器A可排挤低加系统抽汽,板式换热器B和C可减少供暖抽汽耗量。性能试验结果显示,协同烟羽治理余热利用系统在非供暖期可降低机组发电煤耗1.09g/(kW·h),供暖期可降低机组发电煤耗2.30g/(kW·h),节能效益显著。

2型糖尿病患者中载脂蛋白M与脂蛋白a、载脂蛋白AI的关系研究

目的研究2型糖尿病患者中载脂蛋白M(apolipoprote in M,apoM)与脂蛋白及其他载脂蛋白的相关关系。方法用dot-b lotting法检测73例2型糖尿病患者(36男37女)血浆中apoM的水平,酶法及比浊法检测糖尿病患者血浆中载脂蛋白AI(apoAI)、载脂蛋白B(apoB)、脂蛋白a[Lp(a)]、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)以及空腹血糖(G lu),ELISA法测定血浆中瘦素的含量,对apoM与其它脂蛋白、载脂蛋白、瘦素的关系作相关性分析。结果男性病例中,apoM负相关于甘油三酯(r=-0.364 8,P=0.028 7),但与年龄成正相关(r=0.375 2,P=0.026 4)。女性病例中apoM负相关于血浆Lp(a)水平(r=-0.442 0,P=0.007 0),正相关于apoAI/apoB(r=0.458 3,P=0.004 3)。男女病例混合分析发现,apoM负相关于Lp(a)(r=-0.338 5,P=0.003 0),正相关于apoAI(r=0.232 1,P=0.046 6)、瘦素(r=0.247 1,P=0.032 6)和年龄(r=0.242 0,P=0.035 2)。结论apoM负相关于Lp(a),正相关于apoAI、apoAI/apoB,提示了apoM可能是抑制动脉粥样硬化的保护因子。如果体内apoM与apoAI同时升高,可能会降低体内Lp(a)水平。

大鼠肝缺血再灌注损伤过程中apoM mRNA的表达

目的探讨apoMmRNA在大鼠肝缺血再灌注损伤中的表达。方法建立大鼠肝缺血再灌注损伤模型,健康雄性SD大鼠40只随机分成5组,每组8只:假手术组(对照组);IR1组(肝缺血30min);IR2组(肝缺血60min);IR3组(肝缺血120min);IR4组(肝缺血180min)。IR组的再灌注时间统一为60min。观察每1组的病理变化;检测各组血浆谷丙转氨酶水平(ALT);RealtimeRT-PCR检测apoMmRNA在肝脏中的表达。结果肝缺血再灌注后,光镜下大鼠肝组织有明显的肝血窦和中央静脉瘀血,内皮细胞及肝细胞普遍水肿变性,可见肝细胞坏死,这些变化随着缺血时间的延长而逐渐加重。同样的结果见于血浆中ALT的水平。而apoMmRNA的表达有所不同,与对照组相比,IR1组的表达明显下降(P<0.05),随着缺血时间的延长,apoMmRNA的表达开始上升,至IR4及IR5组,其表达已明显高于IR1组(P<0.05)。结论在肝缺血再灌注损伤过程中,肝内apoMmRNA的表达有迅速、明显的变化,提示apoM可能具有急性时相反应蛋白的特性。

肝癌患者血浆apoM水平与其他脂类的相关性研究

目的分析肝癌患者血浆中载脂蛋白M(apoM)的水平,阐明apoM与其他脂蛋白或载脂蛋白的关系。方法应用dot-blotting技术检测36例肝癌患者及64名健康人血浆中apoM的水平,酶法及比浊法检测肝癌患者血浆中TG、TC、apoAI、apoB、Lp(a)、HDL-C、LDL-C;比较原发性肝细胞癌患者和健康人血浆中apoM的水平,并对apoM与其他脂蛋白的关系进行相关性分析。结果血浆apoM水平肝癌组(712.87±345.98)INT/mm2明显高于健康人组(433.70±79.53)INT/mm2(t=3.399,P<0.05),差异具有统计学意义。肝癌患者血浆中的TG、HDL-C、apoAⅠ和Lp(a)水平明显低于健康人,而TC、apoB和LDL-C水平与健康人差异无统计学意义(P>0.05)。以Pearson相关分析法检测健康人组血浆apoM与Lp(a)呈正相关(r=0.6275,P=0.0005),与HDL-C呈负相关(r=-0.4587,P=0.0161),与其他血脂成分无明显的相关性。肝癌患者血浆apoM与血脂参数无相关性。结论肝癌患者血浆apoM水平明显高于健康人,apoM分析有可能作为判断肝癌受损程度的一种辅助指标。

缺血再灌注损伤对载脂蛋白M表达的影响

目的探讨肝缺血再灌注损伤时肝内载脂蛋白M(apoM)mRNA及血浆apoM的表达。方法将40只健康雄性SD大鼠随机分成5组(每组8只)。假手术组(对照组)进腹后仅分离十二指肠韧带,不阻断血流;IR1组灌注0.5h;IR2组缺血60min后再灌注1.0h;IR3组缺血60min后再灌注2.0h、IR4缺血60min后再灌注3.0h。在各时间点活杀大鼠,检测血浆谷丙转氨酶(ALT)水平、肝组织病理变化、血浆apoM蛋白及肝组织apoMmRNA。结果血浆ALT的水平随着灌注时间的延长而升高,肝组织损伤随着灌注时间的延长而逐渐加重。肝组织apoMmRNA的表达则先有一过性下降(IR1组),此后随着灌注时间的延长其表达明显增强。血浆apoM蛋白有相同的变化趋势,但其表达的上升有相应的滞后(IR2组)。结论在肝缺血再灌注损伤过程中,肝脏apoMmRNA的表达和血浆蛋白水平有迅速、明显的变化,提示apoM可能具有急性时相反应蛋白的特性。