The antidepressant effects of the flavonoid-rieh fraction of Monodora tenuifolia seed extract were examined by assess- ing the extent of attenuation of behavioural alterations and oxidative damage in the rats that wer...The antidepressant effects of the flavonoid-rieh fraction of Monodora tenuifolia seed extract were examined by assess- ing the extent of attenuation of behavioural alterations and oxidative damage in the rats that were stressed by forced swim test. Com- pared with the model control group, the altered behavioural parameters were attenuated significantly （P 〈 0.05） in the group treated with the flavonoid-rich fraction （100 and 200 mg·kg^-1）, comparable to the group treated with the standard drug, fluoxetine （10 mg·kg^-1）. The flavonoid-rich fraction and fluoxetine improved significantly （P 〈 0.05） the activities of the antioxidant enzymes such as superoxide dismutase and catalase as well as other biochemical parameters such as reduced glutathione, protein, and nitrite in the brain of the stressed rats. These results suggested that the flavonoid-rich fraction of Monodora tenuifolia seed extract exerted the antidepres- sant-like effects which could be useful in the management of stress induced disease.展开更多
Objective:To determine the beneficial effects of the methanol extract of Synsepalum dulcificum on some biochemical parameters.Methods:In this study,rats were orally administered(gavage)with methanol extracts at doses ...Objective:To determine the beneficial effects of the methanol extract of Synsepalum dulcificum on some biochemical parameters.Methods:In this study,rats were orally administered(gavage)with methanol extracts at doses of 0 mg/kg(Group 1,as normal group),100 mg/kg(Group 2),200 mg/kg(Group 3)and 500 mg/kg(Group 4)body weight per day for 28 d.Results:Acute toxicity study showed that the methanol extract was not toxic to rats up to 5000 mg/kg.From the results,the 100 mg/kg doses of the extract significantly(P<0.05)reduced serum levels of bilirubin,low density lipoprotein,alanine aminotransferase and glucose after 14 d compared with those after 28 d.A significant difference(P<0.05)was observed in the malondialdehyde and serum protein concentration in Group 4 while glucose concentration decreased significantly(P<0.05)in Group 1 and Group 4 after 14 d compared with 28 d.The high density lipoprotein significantly increased(P<0.05)in Group 3.Conclusions:The fruit has no negative effect on some biochemical parameters in albino rats.展开更多
基金supported by the Tertiary Education Trust Fund,Nigeria with grant number 2012
文摘The antidepressant effects of the flavonoid-rieh fraction of Monodora tenuifolia seed extract were examined by assess- ing the extent of attenuation of behavioural alterations and oxidative damage in the rats that were stressed by forced swim test. Com- pared with the model control group, the altered behavioural parameters were attenuated significantly （P 〈 0.05） in the group treated with the flavonoid-rich fraction （100 and 200 mg·kg^-1）, comparable to the group treated with the standard drug, fluoxetine （10 mg·kg^-1）. The flavonoid-rich fraction and fluoxetine improved significantly （P 〈 0.05） the activities of the antioxidant enzymes such as superoxide dismutase and catalase as well as other biochemical parameters such as reduced glutathione, protein, and nitrite in the brain of the stressed rats. These results suggested that the flavonoid-rich fraction of Monodora tenuifolia seed extract exerted the antidepres- sant-like effects which could be useful in the management of stress induced disease.
基金Support by Department of Biochemistry,Faculty of Biological Sciences,University of Nigeria,Nsukka,Enugu State,Nigeria(Grant No:2013).
文摘Objective:To determine the beneficial effects of the methanol extract of Synsepalum dulcificum on some biochemical parameters.Methods:In this study,rats were orally administered(gavage)with methanol extracts at doses of 0 mg/kg(Group 1,as normal group),100 mg/kg(Group 2),200 mg/kg(Group 3)and 500 mg/kg(Group 4)body weight per day for 28 d.Results:Acute toxicity study showed that the methanol extract was not toxic to rats up to 5000 mg/kg.From the results,the 100 mg/kg doses of the extract significantly(P<0.05)reduced serum levels of bilirubin,low density lipoprotein,alanine aminotransferase and glucose after 14 d compared with those after 28 d.A significant difference(P<0.05)was observed in the malondialdehyde and serum protein concentration in Group 4 while glucose concentration decreased significantly(P<0.05)in Group 1 and Group 4 after 14 d compared with 28 d.The high density lipoprotein significantly increased(P<0.05)in Group 3.Conclusions:The fruit has no negative effect on some biochemical parameters in albino rats.
