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Anti-Melanogenesis Effect of Daniellic Acid Isolated from <i>Daniellia oliveri</i>(Rolfe) Hutch. &Dalziel (Leguminosae) Oleoresin of Burkina Faso
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作者 Aminata P. Nacoulma Moussa Compaoré +4 位作者 naamwin-so-bawfu romaric meda Laurent Pottier Véronique Megalizzi Issa Some Martin Kiendrebeogo 《Open Journal of Medicinal Chemistry》 CAS 2021年第4期41-57,共17页
Over the past years, natural products have been used as useful candidates for prevention and treatment of skin disorders such as skin darkening. In this current research, <i><span style="font-family:Verd... Over the past years, natural products have been used as useful candidates for prevention and treatment of skin disorders such as skin darkening. In this current research, <i><span style="font-family:Verdana;">Daniellia oliveri</span></i><span style="font-family:Verdana;"> which was a potential source of cosmeceutical agent was selected to investigate its active components. Daniellic acid isolated from the oleoresin was characterized by using data from </span><sup><span style="font-family:Verdana;">1</span></sup><span style="font-family:Verdana;">H-NMR, </span><sup><span style="font-family:Verdana;">13</span></sup><span style="font-family:Verdana;">C-NMR, HSQC, IR, and online chemo-informatic analysis. The daniellic acid antioxidant, anti-proliferative, and tyrosinase inhibition capabilities were evaluated. This compound possessed an anti-DPPH and iron (III) reducing effect compared to quercetin. It was able to inhibit 9 tumor cells with IC</span><sub><span style="font-family:Verdana;">50</span></sub><span style="font-family:Verdana;"> going from 0.03 mM (U373) to 0.14 mM (Malme-3M). Interestingly daniellic acid inhibit</span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">s</span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;"> tyrosinase activity with 1.20 mM as IC</span><sub><span style="font-family:Verdana;">50</span></sub><span style="font-family:Verdana;">. The tyrosinase inhibition mechanism was noncompetitive mixed-type with un-significant effect on cell melanogenesis. Daniellic acids induced a half-reduction of melanin production in B16F10 cell in IBMX stimulation (p</span></span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">0.05). The same observation was effective in Malme-3M melanin production with a significant daniellic acid action than kojic acid (p</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">0.05) without reducing cell viabilities. This bioactive daniellic acid could explain the traditional uses of oleoresins from </span><i><span style="font-family:Verdana;">Daniellia oliveri</span></i><span style="font-family:Verdana;"> for genitor-urinary tract diseases treatments, wound healing, and skin ailments in Burkina Faso.</span></span></span></span> 展开更多
关键词 Daniellia oliveri Daniellic Acid Tyrosinase MELANOGENESIS Cytotoxicity
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Contribution to the Valorization of Plants Used in the Management of Rheumatic Diseases in Burkina Faso
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作者 Aminata P. Nacoulma Gontili Reine Elodie Karambiri +3 位作者 naamwin-so-bawfu romaric meda Mindiédiba Jean Bangou Moussa Ouedraogo Dieu-Donné Ouedraogo 《Pharmacology & Pharmacy》 2022年第3期81-92,共12页
Joint pain is a real public health problem. According to recent studies, it is increasingly common in sub-Saharan Africa and represents a cause of greater loss of working days than accidents, heart disease and infecti... Joint pain is a real public health problem. According to recent studies, it is increasingly common in sub-Saharan Africa and represents a cause of greater loss of working days than accidents, heart disease and infections. The aim of this study was to study the pharmacochemical and therapeutic evidence of ten (10) plants used in the management of joint pain by traditional health practitioners in Ouagadougou. We conducted a meta-analysis of the data from December 2018 to September 2019. The anti-inflammatory activity of the ten (10) plants retained the maximum consensus internationally. Trichilia emetica Vahl (35.25%), Guiera senegalensis J.F.G.mel. (31%), Calotropis procera (Ait) Ait.F. (28.29%) and Crescientia cujete L. (25.12%) had more than 25% internationally reliability for their effects on joint pain. The structural analogy between conventional drugs and the molecules found in these plants has been confirmed. Additional studies should be carried out in order to improve and secure the use of these plants, which represent a prominent option in the therapeutic offer. 展开更多
关键词 Medicinal Plants ANTI-INFLAMMATORY Rheumatic Pathologies Burkina Faso
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