期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
Mechanisms underlying lineage commitment and plasticity of human yo T cells 被引量:2
1
作者 nadia caccamo Matilde Todaro +3 位作者 Guido Sireci Serena Meraviglia Giorgio Stassi Francesco Dieli 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2013年第1期30-34,共5页
Phenotypic and functional heterogeneity are the hallmarks of effector and memory T cells. Upon antigen stimulation, y T cells differentiate into two major types of memory T cells: central memory cells, which patrol t... Phenotypic and functional heterogeneity are the hallmarks of effector and memory T cells. Upon antigen stimulation, y T cells differentiate into two major types of memory T cells: central memory cells, which patrol the blood and secondary lymphoid organs, and effector memory cells, which migrate to peripheral tissues, y T cells display in vitroa certain degree of plasticity in their function that is reminiscent of that which is observed in conventional CD4 T cells. Similar to CD4 T cells, in which a plethora of specialized subsets affect the host response, y8 T cells may readily and rapidly assume distinct Thl-, Th2-, Th17-, TFH and T regulatory-like effector functions, suggesting that they profoundly influence cell-mediated and humoral immune responses. In addition to differences in cytokine repertoire, y~ T cells exhibit diversity in homing, such as migration to lymph node follicles, to help B cells versus migration to inflamed tissues. Here, we review our current understanding of y T-cell lineage heterogeneity and flexibility, with an emphasis on the human system, and propose a classification of effector y T cells based on distinct functional phenotypes. 展开更多
关键词 CYTOKINES effector and memory cells y T cells lineage-specifying factors T-cell subsets
原文传递
Spatiotemporal mapping of the leprosy granuloma landscape
2
作者 Marco P.La Manna Francesco Dieli nadia caccamo 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2022年第5期558-560,共3页
Leprosy is a chronic infectious disease of humans caused by Mycobacterium leprae(M.leprae)that is prevalent in some countries of Asia,Africa,and South America[1].Leprosy has traditionally been classified into two majo... Leprosy is a chronic infectious disease of humans caused by Mycobacterium leprae(M.leprae)that is prevalent in some countries of Asia,Africa,and South America[1].Leprosy has traditionally been classified into two major types,tuberculoid and lepromatous.Patients with tuberculoid leprosy(TLEP)have limited disease with relatively few bacteria in the skin and nerves and can successfully control the infection. 展开更多
关键词 GRANULOMA NERVES LANDSCAPE
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部