New series of oxovanadium (IV) complexes isolated from 2,4,6-tris-(2-pyridyl)-1,3,5-triazine (L<sup>1</sup>) are incorporated and portrayed using spectroscopic (IR, UV-Vis, ESR, mass spectrometric), magnet...New series of oxovanadium (IV) complexes isolated from 2,4,6-tris-(2-pyridyl)-1,3,5-triazine (L<sup>1</sup>) are incorporated and portrayed using spectroscopic (IR, UV-Vis, ESR, mass spectrometric), magnetic moment, thermal and cyclic voltammetry measurements. The results demonstrate that L<sup>1</sup> acts in various styles of chelation with [V<sub>3</sub>O<sub>3</sub>(L<sup>1</sup>)(SO<sub>4</sub>)<sub>3</sub>(EtOH)<sub>1/2</sub>(H<sub>2</sub>O)<sub>3/2</sub>] 1), [VO(L<sup>1</sup>)(2,4-pentadionate)]·Cl·4HCl 2), [V<sub>2</sub>O<sub>2</sub>(L<sup>1</sup>)(SO<sub>4</sub>)<sub>2</sub>(EtOH)<sub>5/2</sub>] 3), [V<sub>2</sub>O<sub>2</sub>(L<sup>1</sup>)(SO<sub>4</sub>)<sub>2</sub>(EtOH)<sub>3/2</sub>(H<sub>2</sub>O)<sub>1/2</sub>] 4), [VO(L<sup>1</sup>)SO<sub>4</sub> (H<sub>2</sub>O)<sub>3/2</sub>]·2.5H<sub>2</sub>O 5) and [V<sub>2</sub>O<sub>2</sub>(L<sup>1</sup>)(SO<sub>4</sub>)<sub>2</sub>(H<sub>2</sub>O)]·H<sub>2</sub>O 6). The values of magnetic moments and spectral studies suggest a square-pyramidal geometry around the V (IV) ion for all complexes. The molar conductance values suggest that the complexes are non-electrolyte, except the [VO(L<sup>1</sup>) (2,4-pentadionate)] Cl·4HCl. Molecular modeling calculates the bond length, bond angle, chemical reactivity, energy components (Kcal/mol) and binding energy (Kcal/mol) for the isolated complexes. The in vitro antibacterial studies of these complexes screened against pathogenic bacteria prove them as growth inhibiting agents. Antitumor activity is carried out in vitro on human mammary gland (breast) MCF-7 and cervical cancer cell-HeLa has shown that [VO(L<sup>1</sup>)SO<sub>4</sub>(H<sub>2</sub>O)<sub>3/2</sub>]·2.5 H<sub>2</sub>O and [VO(L<sup>1</sup>)(2,4-pentadionate)] Cl·4HCl complexes display the highest powerful activity between all of the investigated complexes.展开更多
文摘New series of oxovanadium (IV) complexes isolated from 2,4,6-tris-(2-pyridyl)-1,3,5-triazine (L<sup>1</sup>) are incorporated and portrayed using spectroscopic (IR, UV-Vis, ESR, mass spectrometric), magnetic moment, thermal and cyclic voltammetry measurements. The results demonstrate that L<sup>1</sup> acts in various styles of chelation with [V<sub>3</sub>O<sub>3</sub>(L<sup>1</sup>)(SO<sub>4</sub>)<sub>3</sub>(EtOH)<sub>1/2</sub>(H<sub>2</sub>O)<sub>3/2</sub>] 1), [VO(L<sup>1</sup>)(2,4-pentadionate)]·Cl·4HCl 2), [V<sub>2</sub>O<sub>2</sub>(L<sup>1</sup>)(SO<sub>4</sub>)<sub>2</sub>(EtOH)<sub>5/2</sub>] 3), [V<sub>2</sub>O<sub>2</sub>(L<sup>1</sup>)(SO<sub>4</sub>)<sub>2</sub>(EtOH)<sub>3/2</sub>(H<sub>2</sub>O)<sub>1/2</sub>] 4), [VO(L<sup>1</sup>)SO<sub>4</sub> (H<sub>2</sub>O)<sub>3/2</sub>]·2.5H<sub>2</sub>O 5) and [V<sub>2</sub>O<sub>2</sub>(L<sup>1</sup>)(SO<sub>4</sub>)<sub>2</sub>(H<sub>2</sub>O)]·H<sub>2</sub>O 6). The values of magnetic moments and spectral studies suggest a square-pyramidal geometry around the V (IV) ion for all complexes. The molar conductance values suggest that the complexes are non-electrolyte, except the [VO(L<sup>1</sup>) (2,4-pentadionate)] Cl·4HCl. Molecular modeling calculates the bond length, bond angle, chemical reactivity, energy components (Kcal/mol) and binding energy (Kcal/mol) for the isolated complexes. The in vitro antibacterial studies of these complexes screened against pathogenic bacteria prove them as growth inhibiting agents. Antitumor activity is carried out in vitro on human mammary gland (breast) MCF-7 and cervical cancer cell-HeLa has shown that [VO(L<sup>1</sup>)SO<sub>4</sub>(H<sub>2</sub>O)<sub>3/2</sub>]·2.5 H<sub>2</sub>O and [VO(L<sup>1</sup>)(2,4-pentadionate)] Cl·4HCl complexes display the highest powerful activity between all of the investigated complexes.
