Background: Purpose of our study was to find out correlation between estimated Glomerular Filtration Rate (GFR) by Modification of Diet in Renal Disease (MDRD) formula and Glomerular Filtration Rate by Cockcroft-Gault...Background: Purpose of our study was to find out correlation between estimated Glomerular Filtration Rate (GFR) by Modification of Diet in Renal Disease (MDRD) formula and Glomerular Filtration Rate by Cockcroft-Gault equations, in patients with chronic kidney disease (CKD), and to see whether they can be used interchangeably. Methods: We conducted a cross section study of 70 patients presented to the nephrology clinic over a period of one year. We compared the Glomerular Filtration Rate by these two formulas in five stages of Chronic Kidney Disease. Abbreviated 4 variable Modification of Diet in Renal Disease formula was used.Results: Age range was 15 - 79 years;Male 49%, Female 51%. The correlation (r) between eGFR by MDRD and eGFR by Cockcroft-Gault equation for CKD stages 1 to 5 was 0.64;0.31;0.32;0.67;and 0.45 respectively. The correlation (r) between creatinine clearance by 24 hour urine collection and MDRD formula was 0.84 (P: 0.001). The correlation (r) between creatinine clearance by 24 hour urine collection Cockcroft-Gault equation was 0.79 (P: 0.001). Conclusion: We conclude that Cockcroft-Gault equation correlates best with MDRD formula at CKD stages 4 and one. Cockcroft-Gault equation underestimated eGFR in stages 1, 2 and 3 of chronic Kidney Disease.展开更多
Background: Kidney biopsy is one of the most important tools in the assessment of kidney disease. Knowing the histopathology is important for immediate clinical management. It helps in predicting the long term prognos...Background: Kidney biopsy is one of the most important tools in the assessment of kidney disease. Knowing the histopathology is important for immediate clinical management. It helps in predicting the long term prognosis and in planning for prevention of chronic kidney disease. Methods: This is a cross section study of percutaneus biopsies of the native kidneys of patients, who presented to the Aga Khan University Hospital Karachi Pakistan, over ten year period from 2003 to 2012. Age range was 16 to 77 years. Results: Total number of 435 biopsies were included in the study. The most common histopathological findings, regardless of the indication of biopsy were Tubulo Interstitial Nephritis in 15 percent, followed by Membranous Nephropathy in 12 percent, Focal Segmental Glomerulosclerosis in 8 percent and Membrano Proliferative Glomerulonephritis also in 8 percent. Conclusion: This study will help in better understanding the spectrum of renal disease in Pakistan. It will guide the clinician in the management and provide a data base or a starting point for the researchers for conducting the controlled and population base studies.展开更多
文摘Background: Purpose of our study was to find out correlation between estimated Glomerular Filtration Rate (GFR) by Modification of Diet in Renal Disease (MDRD) formula and Glomerular Filtration Rate by Cockcroft-Gault equations, in patients with chronic kidney disease (CKD), and to see whether they can be used interchangeably. Methods: We conducted a cross section study of 70 patients presented to the nephrology clinic over a period of one year. We compared the Glomerular Filtration Rate by these two formulas in five stages of Chronic Kidney Disease. Abbreviated 4 variable Modification of Diet in Renal Disease formula was used.Results: Age range was 15 - 79 years;Male 49%, Female 51%. The correlation (r) between eGFR by MDRD and eGFR by Cockcroft-Gault equation for CKD stages 1 to 5 was 0.64;0.31;0.32;0.67;and 0.45 respectively. The correlation (r) between creatinine clearance by 24 hour urine collection and MDRD formula was 0.84 (P: 0.001). The correlation (r) between creatinine clearance by 24 hour urine collection Cockcroft-Gault equation was 0.79 (P: 0.001). Conclusion: We conclude that Cockcroft-Gault equation correlates best with MDRD formula at CKD stages 4 and one. Cockcroft-Gault equation underestimated eGFR in stages 1, 2 and 3 of chronic Kidney Disease.
文摘Background: Kidney biopsy is one of the most important tools in the assessment of kidney disease. Knowing the histopathology is important for immediate clinical management. It helps in predicting the long term prognosis and in planning for prevention of chronic kidney disease. Methods: This is a cross section study of percutaneus biopsies of the native kidneys of patients, who presented to the Aga Khan University Hospital Karachi Pakistan, over ten year period from 2003 to 2012. Age range was 16 to 77 years. Results: Total number of 435 biopsies were included in the study. The most common histopathological findings, regardless of the indication of biopsy were Tubulo Interstitial Nephritis in 15 percent, followed by Membranous Nephropathy in 12 percent, Focal Segmental Glomerulosclerosis in 8 percent and Membrano Proliferative Glomerulonephritis also in 8 percent. Conclusion: This study will help in better understanding the spectrum of renal disease in Pakistan. It will guide the clinician in the management and provide a data base or a starting point for the researchers for conducting the controlled and population base studies.
