We conducted a case-control study to analyse the association of psoriasis of recent onset with smoking habits, body mass index (BMI) and stressful life events. Cases (n = 560; median age 38) were patients with a first...We conducted a case-control study to analyse the association of psoriasis of recent onset with smoking habits, body mass index (BMI) and stressful life events. Cases (n = 560; median age 38) were patients with a first diagnosis of psoriasis and a history of skin manifestations of no longer than two years after the reported disease onset. Patients with a new diagnosis of skin diseases other than psoriasis (n = 690; median age 36) were selected as controls. The risk of psoriasis was higher in ex-and current smokers than in never-smokers, the relative risk estimates (OR) being 1.9 for ex-smokers and 1.7 for smokers. Smoking was strongly associated with pustular lesions (32 patients, OR = 5.3 for smokers). The frequency of psoriasis varied significantly in relation to a family history of psoriasis in first degree relatives, BMI (OR = 1.6 and 1.9 for over weighted, BMI 26-29, and obese, BMI≥30, respectively) and stressful life event score (compared to the lower index quartile, the OR being 2.2 for index values≥115). Risk estimates, when taking into consideration the combined effect of these factors with smoking habits, were consistent with a multiplicative model of risk combination with no significant statistical interaction.展开更多
Background: Limited studies on the prevalence and risk factors for superficial mycoses are available. Objective: The aim of this paper was to evaluate the prevalence and risk factors for superficial mycoses (dermatoph...Background: Limited studies on the prevalence and risk factors for superficial mycoses are available. Objective: The aim of this paper was to evaluate the prevalence and risk factors for superficial mycoses (dermatophytes and Candida spp.) in a sample of young Italian people resident at a military school. Methods: A total of 1,024 young cadets from the Italian Navy Petty Officers School in Taranto,including 975 (95.21%)males and 49 (4.79%) females,mean age 22.5 ±3.0 years (range 18-30),were consecutively examined by the same observer. A complete dermatological examination was performed on all the subjects,and skin scrapings for microscopy and fungal culture were obtained from suspected lesions. All the subjects completed a questionnaire providing information on sports practice,swimming-pool attendance,marching,wearing shower sandals,frequent use of’gummed’shoes,history of severe traumas to the nails,presence of hyperhidrosis and history of superficial mycoses. The affected subjects were also asked if they were aware of their condition. Data were analysed by the Statistical Analysis System,version 8.0. The Fisher exact test and odds ratios were calculated. Results: A total of 33 subjects (3.2%)-were found to suffer from a mycologically confirmed fungal infection (3%by dermatophytes and 0.2%by Candida albicans ): tinea pedis/Candida intertrigo of the feet was suspected in 126 (12.1%) subjects and confirmed in 30 (2.9%),including 28 cases of tinea pedis and 2 cases of Candida intertrigo; tinea cruris/Candida intertrigo of the groin was suspected in 28 (2.7%) subjects,but confirmed in only 1 case (0.1%); onychomycosis was suspected in 64 (6.1%) subjects and confirmed in 2 cases (0.2%). The organism most frequently responsible in tinea pedis was Trichophyton mentagrophytes var. interdigitale (82.1%). The same species (50%) and T. mentagrophytes var. mentagrophytes (50%) were associated with tinea unguium,Epidermophyton floccosum was the only species detected in tinea cruris. Non-dermatophytic filamentous fungi ( Penicillium spp.,Fusarium spp.,Aspergillus spp. and Paecilomyces spp.),not considered pathogenic,were isolated in 48 samples. None of the risk factors analysed were significantly associated with fungal infection. Only 2 subjects out of the 33 people affected were aware of their condition. They both had tinea pedis. Conclusion: The prevalence of mycoses in sailors living in an Italian military school was lower than rates detected in other military populations. This may be due to the cadets’life style and environmental conditions. The most frequent infection was tinea pedis,mainly caused by T. interdigitale. None of the investigated risk factors were significantly associated with the disease,and most of the affected individuals were not aware of their condition.展开更多
The risk of cutaneous malignant melanoma (CMM) is strongly associated with total number of nevi. Scanty information is available on the association betweenCMMat a specific anatomical site and number of nevi at the sam...The risk of cutaneous malignant melanoma (CMM) is strongly associated with total number of nevi. Scanty information is available on the association betweenCMMat a specific anatomical site and number of nevi at the same site. We analyzed data from a case-control study conducted in Italy between 1992 and 1994, on 542 cases of CMM and 538 hospital controls. Cases and controls were examined by trained dermatologists who counted the number of melanocytic nevi. We derived multivariate odds ratios (ORs) and 95%confidence intervals (95%CIs) of site-specific risk of CMM for high versus low number of nevi at the corresponding site. The ORs of CMM for the highest versus the lowest tertile of number of nevi at the corresponding site was 1.4 (95%CIs: 0.7-2.8) at face and neck, 2.3 (95%CIs: 1.1-4.9) at anterior trunk, 4.9 (95%CIs: 2.9-8.4) at posterior trunk, 2.9 (95%CIs: 1.2-6.6) at upper limbs and 5.0 (95%CIs: 2.9-8.5) at lower limbs. In a case-case analysis, comparing CMM cases at a specific site and CMM cases at all other sites, the only excess risk was found for the posterior trunk, the ORs being 2.1 (95%CIs: 1.2-3.6) for the highest versus the lowest tertile of number of nevi. Our data do not support the hypothesis of a specific effect of nevi at each single anatomical site.展开更多
文摘We conducted a case-control study to analyse the association of psoriasis of recent onset with smoking habits, body mass index (BMI) and stressful life events. Cases (n = 560; median age 38) were patients with a first diagnosis of psoriasis and a history of skin manifestations of no longer than two years after the reported disease onset. Patients with a new diagnosis of skin diseases other than psoriasis (n = 690; median age 36) were selected as controls. The risk of psoriasis was higher in ex-and current smokers than in never-smokers, the relative risk estimates (OR) being 1.9 for ex-smokers and 1.7 for smokers. Smoking was strongly associated with pustular lesions (32 patients, OR = 5.3 for smokers). The frequency of psoriasis varied significantly in relation to a family history of psoriasis in first degree relatives, BMI (OR = 1.6 and 1.9 for over weighted, BMI 26-29, and obese, BMI≥30, respectively) and stressful life event score (compared to the lower index quartile, the OR being 2.2 for index values≥115). Risk estimates, when taking into consideration the combined effect of these factors with smoking habits, were consistent with a multiplicative model of risk combination with no significant statistical interaction.
文摘Background: Limited studies on the prevalence and risk factors for superficial mycoses are available. Objective: The aim of this paper was to evaluate the prevalence and risk factors for superficial mycoses (dermatophytes and Candida spp.) in a sample of young Italian people resident at a military school. Methods: A total of 1,024 young cadets from the Italian Navy Petty Officers School in Taranto,including 975 (95.21%)males and 49 (4.79%) females,mean age 22.5 ±3.0 years (range 18-30),were consecutively examined by the same observer. A complete dermatological examination was performed on all the subjects,and skin scrapings for microscopy and fungal culture were obtained from suspected lesions. All the subjects completed a questionnaire providing information on sports practice,swimming-pool attendance,marching,wearing shower sandals,frequent use of’gummed’shoes,history of severe traumas to the nails,presence of hyperhidrosis and history of superficial mycoses. The affected subjects were also asked if they were aware of their condition. Data were analysed by the Statistical Analysis System,version 8.0. The Fisher exact test and odds ratios were calculated. Results: A total of 33 subjects (3.2%)-were found to suffer from a mycologically confirmed fungal infection (3%by dermatophytes and 0.2%by Candida albicans ): tinea pedis/Candida intertrigo of the feet was suspected in 126 (12.1%) subjects and confirmed in 30 (2.9%),including 28 cases of tinea pedis and 2 cases of Candida intertrigo; tinea cruris/Candida intertrigo of the groin was suspected in 28 (2.7%) subjects,but confirmed in only 1 case (0.1%); onychomycosis was suspected in 64 (6.1%) subjects and confirmed in 2 cases (0.2%). The organism most frequently responsible in tinea pedis was Trichophyton mentagrophytes var. interdigitale (82.1%). The same species (50%) and T. mentagrophytes var. mentagrophytes (50%) were associated with tinea unguium,Epidermophyton floccosum was the only species detected in tinea cruris. Non-dermatophytic filamentous fungi ( Penicillium spp.,Fusarium spp.,Aspergillus spp. and Paecilomyces spp.),not considered pathogenic,were isolated in 48 samples. None of the risk factors analysed were significantly associated with fungal infection. Only 2 subjects out of the 33 people affected were aware of their condition. They both had tinea pedis. Conclusion: The prevalence of mycoses in sailors living in an Italian military school was lower than rates detected in other military populations. This may be due to the cadets’life style and environmental conditions. The most frequent infection was tinea pedis,mainly caused by T. interdigitale. None of the investigated risk factors were significantly associated with the disease,and most of the affected individuals were not aware of their condition.
文摘The risk of cutaneous malignant melanoma (CMM) is strongly associated with total number of nevi. Scanty information is available on the association betweenCMMat a specific anatomical site and number of nevi at the same site. We analyzed data from a case-control study conducted in Italy between 1992 and 1994, on 542 cases of CMM and 538 hospital controls. Cases and controls were examined by trained dermatologists who counted the number of melanocytic nevi. We derived multivariate odds ratios (ORs) and 95%confidence intervals (95%CIs) of site-specific risk of CMM for high versus low number of nevi at the corresponding site. The ORs of CMM for the highest versus the lowest tertile of number of nevi at the corresponding site was 1.4 (95%CIs: 0.7-2.8) at face and neck, 2.3 (95%CIs: 1.1-4.9) at anterior trunk, 4.9 (95%CIs: 2.9-8.4) at posterior trunk, 2.9 (95%CIs: 1.2-6.6) at upper limbs and 5.0 (95%CIs: 2.9-8.5) at lower limbs. In a case-case analysis, comparing CMM cases at a specific site and CMM cases at all other sites, the only excess risk was found for the posterior trunk, the ORs being 2.1 (95%CIs: 1.2-3.6) for the highest versus the lowest tertile of number of nevi. Our data do not support the hypothesis of a specific effect of nevi at each single anatomical site.
