AIM： To address the association between serum total IgE levels and age-related cataract in adults. METHODS： The study participants consisted of 1052 adults aged 40y or older in the Korean National Health and Nutriti...AIM： To address the association between serum total IgE levels and age-related cataract in adults. METHODS： The study participants consisted of 1052 adults aged 40y or older in the Korean National Health and Nutrition Examination Survey 2010. We performed multivariable logistic regression analyses using the quartile cut-points of total IgE levels. RESULTS： The odds ratios （ORs） for nuclear and any cataract with ≥267 kU/L of serum IgE levels were 1.75 [95% confidence intervals （CI）, 1.04-2.96] and 2.00 （95%CI, 1.22-3.27）, respectively, comparing to 35-87 kU/L. Interestingly, participants with ≤35 kU/L of IgE levels （OR, 1.67; 95%CI, 1.02-2.72） also had higher risk for any cataract than those with 35-87 kU/L. The risk for any cataract （OR, 1.48; 95%CI, 1.03-2.13） was higher in participants with high total IgE levels （〉150 kU/L）, comparing to normal participants. CONCLUSION： Our findings indicate a J-shaped relationship between serum IgE levels and age-related cataract.展开更多
AIM:To evaluate the possibility of an association between polyethylene glycol(PEG) and acute renal failure(ARF) in elderly patients using a health insurance claims database.METHODS:We conducted a population-based case...AIM:To evaluate the possibility of an association between polyethylene glycol(PEG) and acute renal failure(ARF) in elderly patients using a health insurance claims database.METHODS:We conducted a population-based casecrossover study using information obtained from Korean Health Insurance Review and Assessment Service(HIRA) claims from January 1,2005 to December 31,2005(Seoul,Korea).The study population consisted of elderly patients who received PEG prior to experiencing their first ARF-related hospitalization from April 1,2005 to December 31,2005.For each patient,one case and two control periods were matched.PEG use in a 2-or 4-wk window period prior to hospitalization for ARF was compared with PEG use in two earlier 2-or 4-wk control window periods.Conditional logistic regression analysis was used to estimate odds ratios(ORs) and 95% CI,adjusting for concomitant uses of diuretics,angiotensin converting enzyme inhibitors,non-steroidal anti-inflammatory drugs,antibiotics,anti-cancer drugs,and contrast media.RESULTS:Within the HIRA database which contained 1 093 262 elderly patients,1156 hospitalized ARF cases were identified.Among these cases,PEG was prescribed to 17(1.5%) patients before hospitalization.The adjusted ORs when applying the 2-and 4-wk window periods were 0.4(95% CI:0.03-5.24) and 2.1(95% CI:0.16-27.78),respectively.CONCLUSION:No increased risk of ARF was found in elderly PEG users.However,based on the limited number of study subjects,further analysis should be performed to confirm these results.展开更多
文摘AIM： To address the association between serum total IgE levels and age-related cataract in adults. METHODS： The study participants consisted of 1052 adults aged 40y or older in the Korean National Health and Nutrition Examination Survey 2010. We performed multivariable logistic regression analyses using the quartile cut-points of total IgE levels. RESULTS： The odds ratios （ORs） for nuclear and any cataract with ≥267 kU/L of serum IgE levels were 1.75 [95% confidence intervals （CI）, 1.04-2.96] and 2.00 （95%CI, 1.22-3.27）, respectively, comparing to 35-87 kU/L. Interestingly, participants with ≤35 kU/L of IgE levels （OR, 1.67; 95%CI, 1.02-2.72） also had higher risk for any cataract than those with 35-87 kU/L. The risk for any cataract （OR, 1.48; 95%CI, 1.03-2.13） was higher in participants with high total IgE levels （〉150 kU/L）, comparing to normal participants. CONCLUSION： Our findings indicate a J-shaped relationship between serum IgE levels and age-related cataract.
文摘AIM:To evaluate the possibility of an association between polyethylene glycol(PEG) and acute renal failure(ARF) in elderly patients using a health insurance claims database.METHODS:We conducted a population-based casecrossover study using information obtained from Korean Health Insurance Review and Assessment Service(HIRA) claims from January 1,2005 to December 31,2005(Seoul,Korea).The study population consisted of elderly patients who received PEG prior to experiencing their first ARF-related hospitalization from April 1,2005 to December 31,2005.For each patient,one case and two control periods were matched.PEG use in a 2-or 4-wk window period prior to hospitalization for ARF was compared with PEG use in two earlier 2-or 4-wk control window periods.Conditional logistic regression analysis was used to estimate odds ratios(ORs) and 95% CI,adjusting for concomitant uses of diuretics,angiotensin converting enzyme inhibitors,non-steroidal anti-inflammatory drugs,antibiotics,anti-cancer drugs,and contrast media.RESULTS:Within the HIRA database which contained 1 093 262 elderly patients,1156 hospitalized ARF cases were identified.Among these cases,PEG was prescribed to 17(1.5%) patients before hospitalization.The adjusted ORs when applying the 2-and 4-wk window periods were 0.4(95% CI:0.03-5.24) and 2.1(95% CI:0.16-27.78),respectively.CONCLUSION:No increased risk of ARF was found in elderly PEG users.However,based on the limited number of study subjects,further analysis should be performed to confirm these results.
