Design of 4D printed shape-changing tracheal stent and remote controlling actuation

has a good application prospect.The biodegradable stent can effectively reduce the damage to patients and improve the therapeutic performance of stents.In this work,a series of shape memory polylactic acid(Fe_(3)O_(4))composite tracheal stents were manufactured by 4D printing.The composite tracheal stents with different structures were designed.Moreover,with the addition of magnetic particles Fe3 O4,the shape memory PLA/Fe_(3)O_(4)composite tracheal stent has a magnetic driving effect.Under the magnetic field,the shape recovery process is completed within 40 s,and the shape recovery rate is more than 99%.Moreover,the 4D printed tracheal stent was also triggered by the irradiation of infrared lamp to realize the remote controlling recovery.The research on the structure design and driving method of 4D printing tracheal stent expands the application scope of shape memory polymer composites in biomedical field,provides a new way for personalized implantable medical devices and minimally invasive surgery.It is of great significance for better precision medical treatment.

MicroRNAs通过调节自噬影响乳腺癌的耐药性

自噬是一种保守的分解代谢过程,其特征在于通过溶酶体依赖性途径降解和再循环胞质成分或细胞器。它与乳腺癌的耐药性有着复杂而密切的关系。小分子核糖核酸(micro RNA,mi RNA)是小的非编码分子,可通过基因表达的转录后调控来影响众多细胞过程,包括自噬。许多蛋白质和途径能调节自噬,而其中一些反过来又被mi RNA调节。另外,这些mi RNA可能会影响乳腺癌的耐药性。耐药性是乳腺癌患者远处复发、转移和死亡的主要原因。在这篇综述中,我们总结了乳腺癌自噬与药物耐药性之间的因果关系,同时还讨论了自噬相关蛋白和途径及其相关的mi RNA在乳腺癌耐药性中的作用。