In 1957,Macfarlane Burnet proposed the theory that harnessing the body’s immune system could be an effective method for cancer treatment[1].Today,T-cell-based immunotherapies have indeed become a vital part of cancer...In 1957,Macfarlane Burnet proposed the theory that harnessing the body’s immune system could be an effective method for cancer treatment[1].Today,T-cell-based immunotherapies have indeed become a vital part of cancer treatment[2].However,a deeper understanding of antitumor immunity is still necessary to further support these treatments.Notably,CD4^(+)T cells are central to mediating antitumor immune responses[3,4,5,6],yet the cellular and molecular programs governing CD4^(+)T-cell antitumor immunity remain unclear.Our recent research revealed that CD4^(+)T-cell immunity is critically dependent on an intrinsic stem-like program[7].展开更多
文摘In 1957,Macfarlane Burnet proposed the theory that harnessing the body’s immune system could be an effective method for cancer treatment[1].Today,T-cell-based immunotherapies have indeed become a vital part of cancer treatment[2].However,a deeper understanding of antitumor immunity is still necessary to further support these treatments.Notably,CD4^(+)T cells are central to mediating antitumor immune responses[3,4,5,6],yet the cellular and molecular programs governing CD4^(+)T-cell antitumor immunity remain unclear.Our recent research revealed that CD4^(+)T-cell immunity is critically dependent on an intrinsic stem-like program[7].
