Gluconacetobacter hansenii GK-1 is an acid-resistant gram-negative bacterium used in vinegar brewing. Oral ingestion of GK-1 was previously reported to help maintain immunity and reduce nasal discomfort. Considering t...Gluconacetobacter hansenii GK-1 is an acid-resistant gram-negative bacterium used in vinegar brewing. Oral ingestion of GK-1 was previously reported to help maintain immunity and reduce nasal discomfort. Considering the suggested mechanism of action of activation of regulatory T cells via TLR4 to control Th1/Th2 balancing, GK-1 is also assumed to reduce skin discomfort secondary to immune reactions;however, this has not been validated in humans. Thus, we conducted a randomized, double-blind, placebo-controlled, parallel-group study on 100 healthy Japanese men and women (mean age, 47.6 ± 1.01 years) aged 20–64 years who consumed GK-1 (9 × 109 cells) daily for 8 weeks. Visual analog scale for overall, facial, arm, and leg skin discomfort was assessed before and after ingestion. The cumulative days of skin discomfort during the ingestion period were assessed. Compared with the placebo group, the G. hansenii GK-1 group had a significantly lower visual analog scale for overall and facial skin discomfort after 8 weeks and cumulative days of skin discomfort. Moreover, there were no adverse events attributable to G. hansenii GK-1. This study confirmed that oral ingestion of G. hansenii GK-1 contributed to skin integrity. The study protocol was preregistered at the Clinical Trials Registry System (registration no. UMIN000053005, December 7, 2023).展开更多
Objective: Few studies have evaluated the effect of oral sodium hyaluronate (SH) ingestion on the moisture content of the superficial stratum corneum. This study aimed to assess whether oral SH ingestion improves the ...Objective: Few studies have evaluated the effect of oral sodium hyaluronate (SH) ingestion on the moisture content of the superficial stratum corneum. This study aimed to assess whether oral SH ingestion improves the moisture content of the upper layer of the stratum corneum, which is susceptible to changes in environmental humidity, using the Skicon 200EX. Design: Randomized, double-blind, placebo-controlled, parallel-group study. Participants: One hundred healthy Japanese men and women aged 20 - 64 years. Interventions: Oral ingestion of one 119-mg SH or dextrin (placebo) capsule once daily for 8 weeks. Evaluations: Measurement of water content in the superficial stratum corneum of the face and upper extremities using the Skicon 200EX. Results: Overall facial stratum corneum water content changes were significantly higher at 8 weeks in the SH group compared to the placebo group. Conclusions: In healthy Japanese adults, oral SH ingestion improved skin moisture by increasing the stratum corneum water content. Clinical Trial Registration: The study protocol was preregistered with the Clinical Trials Registry System (registration no. UMIN000053322, January 11, 2024).展开更多
文摘Gluconacetobacter hansenii GK-1 is an acid-resistant gram-negative bacterium used in vinegar brewing. Oral ingestion of GK-1 was previously reported to help maintain immunity and reduce nasal discomfort. Considering the suggested mechanism of action of activation of regulatory T cells via TLR4 to control Th1/Th2 balancing, GK-1 is also assumed to reduce skin discomfort secondary to immune reactions;however, this has not been validated in humans. Thus, we conducted a randomized, double-blind, placebo-controlled, parallel-group study on 100 healthy Japanese men and women (mean age, 47.6 ± 1.01 years) aged 20–64 years who consumed GK-1 (9 × 109 cells) daily for 8 weeks. Visual analog scale for overall, facial, arm, and leg skin discomfort was assessed before and after ingestion. The cumulative days of skin discomfort during the ingestion period were assessed. Compared with the placebo group, the G. hansenii GK-1 group had a significantly lower visual analog scale for overall and facial skin discomfort after 8 weeks and cumulative days of skin discomfort. Moreover, there were no adverse events attributable to G. hansenii GK-1. This study confirmed that oral ingestion of G. hansenii GK-1 contributed to skin integrity. The study protocol was preregistered at the Clinical Trials Registry System (registration no. UMIN000053005, December 7, 2023).
文摘Objective: Few studies have evaluated the effect of oral sodium hyaluronate (SH) ingestion on the moisture content of the superficial stratum corneum. This study aimed to assess whether oral SH ingestion improves the moisture content of the upper layer of the stratum corneum, which is susceptible to changes in environmental humidity, using the Skicon 200EX. Design: Randomized, double-blind, placebo-controlled, parallel-group study. Participants: One hundred healthy Japanese men and women aged 20 - 64 years. Interventions: Oral ingestion of one 119-mg SH or dextrin (placebo) capsule once daily for 8 weeks. Evaluations: Measurement of water content in the superficial stratum corneum of the face and upper extremities using the Skicon 200EX. Results: Overall facial stratum corneum water content changes were significantly higher at 8 weeks in the SH group compared to the placebo group. Conclusions: In healthy Japanese adults, oral SH ingestion improved skin moisture by increasing the stratum corneum water content. Clinical Trial Registration: The study protocol was preregistered with the Clinical Trials Registry System (registration no. UMIN000053322, January 11, 2024).
