Low toxic graphene quantum dot（GQD） was synthesized by pyrolyzing citric acid in alkaline solution and characterized by ultraviolet-visible（UV-vis） spectroscopy,X-ray diffraction（XRD）,atomic force microscopy（AF...Low toxic graphene quantum dot（GQD） was synthesized by pyrolyzing citric acid in alkaline solution and characterized by ultraviolet-visible（UV-vis） spectroscopy,X-ray diffraction（XRD）,atomic force microscopy（AFM）,spectrofluorimetery and dynamic light scattering（DLS） techniques.GQD was used for electrode modification and electro-oxidation of doxorubicin（DOX） at low potential.A substantial decrease in the overvoltage（- 0.56 V） of the DOX oxidation reaction（compared to ordinary electrodes） was observed using GQD as coating of glassy carbon electrode（GCE）.Differential pulse voltammetry was used to evaluate the analytical performance of DOX in the presence of phosphate buffer solution（pH 4.0） and good limit of detection was obtained by the proposed sensor.Such ability of GQD to promote the DOX electron-transfer reaction suggests great promise for its application as an electrochemical sensor.展开更多
基金financial support by the Hematology-Oncology Research Center,Tabriz University of Medical Sciences,under Grants No.93/5
文摘Low toxic graphene quantum dot（GQD） was synthesized by pyrolyzing citric acid in alkaline solution and characterized by ultraviolet-visible（UV-vis） spectroscopy,X-ray diffraction（XRD）,atomic force microscopy（AFM）,spectrofluorimetery and dynamic light scattering（DLS） techniques.GQD was used for electrode modification and electro-oxidation of doxorubicin（DOX） at low potential.A substantial decrease in the overvoltage（- 0.56 V） of the DOX oxidation reaction（compared to ordinary electrodes） was observed using GQD as coating of glassy carbon electrode（GCE）.Differential pulse voltammetry was used to evaluate the analytical performance of DOX in the presence of phosphate buffer solution（pH 4.0） and good limit of detection was obtained by the proposed sensor.Such ability of GQD to promote the DOX electron-transfer reaction suggests great promise for its application as an electrochemical sensor.
