期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Body temperature control in fever modeling after preliminary injection of glutamate receptors ligands into the solitary tract nucleus
1
作者 Stanislav V. Koulchitsky Svetlana G. Pashkevich +2 位作者 nastassia m. navasiolava marc-Antoine Custaud Vladimir A. Kulchitsky 《Advances in Bioscience and Biotechnology》 2013年第4期557-562,共6页
Deep body temperature of 57 male Wistar rats was measured in response to systemic (i.v. or i.p.) injection of Escherichia coli lipopolysaccharide (LPS). Animals were preliminarily (4 weeks before the experiment) treat... Deep body temperature of 57 male Wistar rats was measured in response to systemic (i.v. or i.p.) injection of Escherichia coli lipopolysaccharide (LPS). Animals were preliminarily (4 weeks before the experiment) treated with microinjections of the toxic dose of glutamate receptors agonists or vehicle into solitary tract nucleus or caudal part of ventrolateral medulla. Microinjections of the glutamate receptors agonists provoked a local destruction of brain tissue, which was accompanied by the significant transformation (amplification or attenuation) of temperature response to the systemic injection of 3 μg/kg E. coli LPS. Animals treated with vehicle did not demonstrate significant changes in their response to LPS. Obtained data testify that impairment of central nervous structure involved in the regulation and maintenance of deep body temperature is accompanied by atypical development of E. coli LPS-induced fever. 展开更多
关键词 ESCHERICHIA coli ENDOTOXIN BRAINSTEM Fever CONTROL Body Temperature Defense REFLEXES
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部