Protein chemical modifications are important tools for elucidating chemical and biological functions of proteins.Several strategies have been developed to implement these modifications,including enzymatic tailoring re...Protein chemical modifications are important tools for elucidating chemical and biological functions of proteins.Several strategies have been developed to implement these modifications,including enzymatic tailoring reactions,unnatural amino acid incorporation using the expanded genetic codes,and recognition-driven transformations.These technologies have been applied in metalloenzyme studies,specifically in dissecting their mechanisms,improving their enzymatic activities,and creating artificial enzymes with non-natural activities.Herein,we summarize some of the recent efforts in these areas with an emphasis on a few metalloenzyme case studies.展开更多
Ferroptosis is an iron-dependent, non-apoptotic cell death program marked by aberrant accumulation of membranea-ssociated lipid radicals and hydroperoxides (Zou and Schreiber, 2020). Normal cells deploy multiple mecha...Ferroptosis is an iron-dependent, non-apoptotic cell death program marked by aberrant accumulation of membranea-ssociated lipid radicals and hydroperoxides (Zou and Schreiber, 2020). Normal cells deploy multiple mechanisms.展开更多
基金This research was partially supported by National Science Foundation(CHE-2004109 to P.L.)。
文摘Protein chemical modifications are important tools for elucidating chemical and biological functions of proteins.Several strategies have been developed to implement these modifications,including enzymatic tailoring reactions,unnatural amino acid incorporation using the expanded genetic codes,and recognition-driven transformations.These technologies have been applied in metalloenzyme studies,specifically in dissecting their mechanisms,improving their enzymatic activities,and creating artificial enzymes with non-natural activities.Herein,we summarize some of the recent efforts in these areas with an emphasis on a few metalloenzyme case studies.
基金supported by the Westlake Education Foundationthe Westlake Laboratory of Life Sciences and Biomedicine
文摘Ferroptosis is an iron-dependent, non-apoptotic cell death program marked by aberrant accumulation of membranea-ssociated lipid radicals and hydroperoxides (Zou and Schreiber, 2020). Normal cells deploy multiple mechanisms.
