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新生儿复温期间脑血流量和氧合作用的持续测定
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作者 naulaers g. Cossey V. +1 位作者 Morren g. 平智广 《世界核心医学期刊文摘(儿科学分册)》 2005年第4期15-15,共1页
目的:调查复温对住院的低体温早产儿的治疗效果。方法:测定了8例体温【350℃的住院早产儿的组织氧合指数(TOI)、脑血流量变化(△CBV)和血管内氧合度变化(△HbD)。结果:4例患儿(A组)的HbD和TOI显著升高,另外4例患儿(B组)的CBV明显升高而... 目的:调查复温对住院的低体温早产儿的治疗效果。方法:测定了8例体温【350℃的住院早产儿的组织氧合指数(TOI)、脑血流量变化(△CBV)和血管内氧合度变化(△HbD)。结果:4例患儿(A组)的HbD和TOI显著升高,另外4例患儿(B组)的CBV明显升高而HbD降低。回顾性分析表明A组患儿曾有明显的围生期窒息征象。结论:围生期有明显窒息征象的新生儿在复温过程中其体内氧合作用明显提高,而在无窒息征象的新生儿中则没有明显改变。 展开更多
关键词 氧合作用 复温 围生期窒息 脑血流量 血管内氧合 氧合指数 低体温 OXYGENATION ADMISSION 程中
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水合氯醛用于早产儿的药效动力学
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作者 Allegaert K. Daniels H. +1 位作者 naulaers g. 韩浩 《世界核心医学期刊文摘(儿科学分册)》 2005年第12期24-25,共2页
The aim of this study was to document the pharmacodynamics of chloral hydrate in former preterm infants at term post-conception age. The degree of sedation (COMFORT), feeding behaviour and cardiorespiratory events (br... The aim of this study was to document the pharmacodynamics of chloral hydrate in former preterm infants at term post-conception age. The degree of sedation (COMFORT), feeding behaviour and cardiorespiratory events (bradycard-ic events, apnoeas) before and after administration of chloral hydrate (oral, 30 mg/kg) were prospectively eva-luated in former preterm infants during procedural sedation. Characteristics at birth, during neonatal stay and at inclusion were collected. Paired Wilcoxon and McNemar tests were used to study the impact of chloral hydrate. Characteristics of infants who displayed severe bradycardic events were compared to infants in whom no bradycardic events were recorded (MannWhitney U, Fischer’s exact). A significant increase in sedation (decrease COMFORT scale) was observed up to 12 h after administration. There was a minor but significant decrease in oral intake (161 to 156 ml/kg/day, P < 0.01). A significant increase in the number of bradycardic events (< 80/min: 38 to 82 events, of which < 70/min: 30 to 79 of which < 60/min: 15 to 45; at least P < 0.01) and in the duration of the most severe bradycardic event (8- 12.5 s) was observed. Therefore, further inclusion was stopped when 26 neonates were included. Infants who displayed severe bradycardic (< 60/min) events ( n=13) after administration of chloral hydrate had a lower gestational age at birth without difference in post-conception age at inclusion. Conclusion: Chloral hydrate was associated with an increase in unintended side-effects in former preterm infants, likely reflecting population specific pharmacodynamics and kinetics of chloral hydrate. 展开更多
关键词 水合氯醛 药效动力学 严重心动过缓 新生儿时期 进食行为 症状持续时间 药代动力学 镇静作用 出生后 呼吸暂停
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布洛芬对早产儿脑循环及氧合指数的影响
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作者 naulaers g. Delanghe g. +1 位作者 Allegaert K. 宁亮 《世界核心医学期刊文摘(儿科学分册)》 2005年第9期10-10,共1页
The effect of prophylactic administration of ibuprofen on the cerebral circulation in preterm babies was measured with near infrared spectroscopy. No significant difference in the change in cerebral blood volume, chan... The effect of prophylactic administration of ibuprofen on the cerebral circulation in preterm babies was measured with near infrared spectroscopy. No significant difference in the change in cerebral blood volume, change in cerebral blood flow, or tissue oxygenation index was found between administration of ibuprofen or placebo. 展开更多
关键词 氧合指数 脑循环 脑血容量 检查法 脑血流量 红外分光 安慰剂 药对
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