Alteration of Ground Motion Acceleration at Ground Level Due To Tunnel Excavation

Underground tunneling is one of the alternative solutions to diminish traffic congestion in large cities. One of the most important effects of tunneling is the displacement of the ground surface, the settlement around the tunnel, and the variation in earthquake acceleration. The performance and behavior of underground structures have been studied by several researchers, but the impact of tunnel excavation on earthquake records and its effects on structures above the ground level have received less attention. This research emphasizes changes of earthquake acceleration at the ground level, structural response and Fourier spectrum by excavating a horseshoe tunnel. Results show that digging a horseshoe tunnel will change the characteristics of the earthquake record at ground level.

ALK-Rearranged Lung Adenocarcinoma Initially Presenting with Cutaneous Metastases: A Case Report

Only 1% - 12% of patients with lung cancer develop cutaneous metastases. While adenocarcinoma is incredibly common, it is rare for a cutaneous manifestation of the disease to be the initial presenting complaint. Skin manifestations can be difficult to identify and can appear to be deceptively benign, leading to delays in diagnosis and treatment. ALK+ lung cancer specifically has an increased frequency of distant lymph node involvement and lymphangitic carcinomatosis relative to typical EGFR+ lung cancer. Herein we report a case of ALK-rearranged lung adenocarcinoma that initially presented as cutaneous skin metastases to the neck. Such skin lesions should be identified early, and considered as a potential manifestation of an internal malignancy. Given the poor prognosis associated with cutaneous metastases, further diagnostic tests, such as imaging or biopsy, should be done with urgency.