Rationale:Dengue fever is a leading cause of death in tropical and subtropical countries.Although most patients have a self-limited febrile illness,the viral infection can induce virus-mediated host changes,making imm...Rationale:Dengue fever is a leading cause of death in tropical and subtropical countries.Although most patients have a self-limited febrile illness,the viral infection can induce virus-mediated host changes,making immunocompetent persons susceptible to deadly fungal infections.However,there are only a few reports of such an association.Here we present a case of this deadly co-infection.Patient’s Concern:A 17-year-old male patient was diagnosed with dengue fever.He presented to us with facial swelling,periorbital edema,and black discoloration over the palate during the second week of his illness.Diagnosis:Diagnostic tests confirmed the presence of fungal hyphae.A diagnosis of post-dengue mucormycosis was made.No other comorbidity or underlying immune deficit was detected.Interventions:The patient underwent surgical debridement and antifungal treatment.Outcomes:The patient recovered and showed signs of palatal healing with an advancing mucosal edge.Lessons:Dengue virus and mucor co-infection has brought to light a new pathogenic paradigm.Clinicians need to be aware of this emerging medical condition and maintain a high index of suspicion for mucor co-infections while treating dengue patients.展开更多
Microglial cells are non-neuronal cells which serve as the first line of defence against various injuries and insults in the central nervous system(CNS).They act as sentinels that constantly patrol the surrounding par...Microglial cells are non-neuronal cells which serve as the first line of defence against various injuries and insults in the central nervous system(CNS).They act as sentinels that constantly patrol the surrounding parenchyma through their ramified processes in the CNS.In response to any pathological insult,microglia become activated,undergo proliferation,migrate to the site of injury or infection,and release chemokines and cytokines followed by the phagocytosis of dead cells and debris.展开更多
文摘Rationale:Dengue fever is a leading cause of death in tropical and subtropical countries.Although most patients have a self-limited febrile illness,the viral infection can induce virus-mediated host changes,making immunocompetent persons susceptible to deadly fungal infections.However,there are only a few reports of such an association.Here we present a case of this deadly co-infection.Patient’s Concern:A 17-year-old male patient was diagnosed with dengue fever.He presented to us with facial swelling,periorbital edema,and black discoloration over the palate during the second week of his illness.Diagnosis:Diagnostic tests confirmed the presence of fungal hyphae.A diagnosis of post-dengue mucormycosis was made.No other comorbidity or underlying immune deficit was detected.Interventions:The patient underwent surgical debridement and antifungal treatment.Outcomes:The patient recovered and showed signs of palatal healing with an advancing mucosal edge.Lessons:Dengue virus and mucor co-infection has brought to light a new pathogenic paradigm.Clinicians need to be aware of this emerging medical condition and maintain a high index of suspicion for mucor co-infections while treating dengue patients.
基金This work was supported by the NUS Strategic Research Grant(Memory Networks in Rodent and Primate)DPRT/944/09/14(R185-000-271-646)(to STD)Ministry of Education(Tier 2)grant(R181-000-186-112)(to STD).
文摘Microglial cells are non-neuronal cells which serve as the first line of defence against various injuries and insults in the central nervous system(CNS).They act as sentinels that constantly patrol the surrounding parenchyma through their ramified processes in the CNS.In response to any pathological insult,microglia become activated,undergo proliferation,migrate to the site of injury or infection,and release chemokines and cytokines followed by the phagocytosis of dead cells and debris.
