Nanodiamonds are novel nanosized carbon building blocks possessing varied fascinating mechanical,chemical,optical and biological properties,making them significant active moiety carriers for biomedical application.The...Nanodiamonds are novel nanosized carbon building blocks possessing varied fascinating mechanical,chemical,optical and biological properties,making them significant active moiety carriers for biomedical application.These are known as the most‘captivating’crystals attributed to their chemical inertness and unique properties posing them useful for variety of applications in biomedical era.Alongside,it becomes increasingly important to find,ascertain and circumvent the negative aspects associated with nanodiamonds.Surface modification or functionalization with biological molecules plays a significant role in managing the toxic behavior since nanodiamonds have tailorable surface chemistry.To take advantage of nanodiamond potential in drug delivery,focus has to be laid on its purity,surface chemistry and other considerations which may directly or indirectly affect drug adsorption on nanodiamond and drug release in biological environment.This review emphasizes on the basic properties,synthesis techniques,surface modification techniques,toxicity issues and biomedical applications of nanodiamonds.For the development of nanodiamonds as an effective dosage form,researchers are still engaged in the in-depth study of nanodiamonds and their effect on life interfaces.展开更多
Depression is a serious medical condition and is a leading cause of disability worldwide.Current depression diagnostics and assessment has significant limitations due to heterogeneity of clinical presentations,lack of...Depression is a serious medical condition and is a leading cause of disability worldwide.Current depression diagnostics and assessment has significant limitations due to heterogeneity of clinical presentations,lack of objective assessments,and assessments that rely on patients'perceptions,memory,and recall.Digital phenotyping(DP),especially assessments conducted using mobile health technologies,has the potential to greatly improve accuracy of depression diagnostics by generating objectively measurable endophenotypes.DP includes two primary sources of digital data generated using ecological momentary assessments(EMA),assessments conducted in real-time,in subjects'natural environment.This includes active EMA,data that require active input by the subject,and passive EMA or passive sensing,data passively and automatically collected from subjects'personal digital devices.The raw data is then analyzed using machine learning algorithms to identify behavioral patterns that correlate with patients'clinical status.Preliminary investigations have also shown that linguistic and behavioral clues from social media data and data extracted from the electronic medical records can be used to predict depression status.These other sources of data and recent advances in telepsychiatry can further enhance DP of the depressed patients.Success of DP endeavors depends on critical contributions from both psychiatric and engineering disciplines.The current review integrates important perspectives from both disciplines and discusses parameters for successful interdisciplinary collaborations.A clinically-relevant model for incorporating DP in clinical setting is presented.This model,based on investigations conducted by our group,delineates development of a depression prediction system and its integration in clinical setting to enhance depression diagnostics and inform the clinical decision making process.Benefits,challenges,and opportunities pertaining to clinical integration of DP of depression diagnostics are discussed from interdisciplinary perspectives.展开更多
Novel and simplified bi-layer top-emitting white organic light emitting diodes(OLEDs)with dual co-host emitters have been simulated and analyzed.They consist of yellow-green emitting layer(EML)as electron transport la...Novel and simplified bi-layer top-emitting white organic light emitting diodes(OLEDs)with dual co-host emitters have been simulated and analyzed.They consist of yellow-green emitting layer(EML)as electron transport layer(ETL)and blue EML as hole transport layer(HTL).Novelty of the device lies in simplification of tri-layer white OLED to a bi-layered device which is done by merging yellow-green EML with ETL and blue EML with HTL.The simulated devices show Commission Internationale de L’Eclairage(CIE)colour coordinates well within the emission range of white light.The results show that device A with 5,6,11,12-tetraphenylnaphthacene(rubrene)doped ETL has achieved the lowest luminance but longest excited state lifetime.Device D with tris-(8-hydroxyquinoline)aluminum:4-(dicyanomethylene)-2-t-butyle-6-(1,1,7,7-tetra-methyljulolidyl-9-enyl)4 H-pyran(Alq3:DCJTB)as ETL which emits yellow light and 2,7-bis[N,N-bis(4-methoxy-phenyl)amino]-9,9-spirobifluorene(MS-TPD):bis(2-methyl-8-quninolinato)-4-phenylphenolate alu-minium(BAlq)as HTL which is responsible for blue light emission is found to have best characteristics when compared to other simulated devices.It has a maximum luminance of 10000 cd/m2 and current efficiency of 15.25 cd/A,respectively,and CIE coordinates are at(0.329,0.319).The device is found to be compatible to be used in solid state lighting applications because of the low driving voltage of the device.展开更多
To increase the current density of the hole only device, 1, 4, 5, 8, 9, 11-hexaazatriphenylene-hexacarbonitrile (HAT-CN) material has been inserted in the device at the indium tin oxide (ITO)/organic interface. Since ...To increase the current density of the hole only device, 1, 4, 5, 8, 9, 11-hexaazatriphenylene-hexacarbonitrile (HAT-CN) material has been inserted in the device at the indium tin oxide (ITO)/organic interface. Since HATCN molecule can withdraw electrons, it can alter electronic properties of the electrodes and hence inserted between the organic/metal interfaces. This paper deals with the optimization of the thickness of organic-metal layers to enhance the efficiency. Also, efforts have been made to increase the current density and reduce the operating voltage of the device. The material 2, 7-bis [N, N-bis (4- methoxy-phenyl) amino]-9, 9-spirobifluorene (Meo-Spiro-TPD) is used to simulate the hole only device because it is a thermally stable hole transport material. Simulated results shows that better current density values can be achieved compared to fabricated one by optimizing the organic metal layer thickness. The best optimized layer thickness of 22 nm for Alq3, 25 nm for *CBP doped with Ir(ppy)3, 9 nm for Meo-Spiro TPD and 4 nm for HAT-CN which results in current density of 0.12 A/cm2 with a reduction in operating voltage by approximately 2 V.展开更多
文摘Nanodiamonds are novel nanosized carbon building blocks possessing varied fascinating mechanical,chemical,optical and biological properties,making them significant active moiety carriers for biomedical application.These are known as the most‘captivating’crystals attributed to their chemical inertness and unique properties posing them useful for variety of applications in biomedical era.Alongside,it becomes increasingly important to find,ascertain and circumvent the negative aspects associated with nanodiamonds.Surface modification or functionalization with biological molecules plays a significant role in managing the toxic behavior since nanodiamonds have tailorable surface chemistry.To take advantage of nanodiamond potential in drug delivery,focus has to be laid on its purity,surface chemistry and other considerations which may directly or indirectly affect drug adsorption on nanodiamond and drug release in biological environment.This review emphasizes on the basic properties,synthesis techniques,surface modification techniques,toxicity issues and biomedical applications of nanodiamonds.For the development of nanodiamonds as an effective dosage form,researchers are still engaged in the in-depth study of nanodiamonds and their effect on life interfaces.
文摘Depression is a serious medical condition and is a leading cause of disability worldwide.Current depression diagnostics and assessment has significant limitations due to heterogeneity of clinical presentations,lack of objective assessments,and assessments that rely on patients'perceptions,memory,and recall.Digital phenotyping(DP),especially assessments conducted using mobile health technologies,has the potential to greatly improve accuracy of depression diagnostics by generating objectively measurable endophenotypes.DP includes two primary sources of digital data generated using ecological momentary assessments(EMA),assessments conducted in real-time,in subjects'natural environment.This includes active EMA,data that require active input by the subject,and passive EMA or passive sensing,data passively and automatically collected from subjects'personal digital devices.The raw data is then analyzed using machine learning algorithms to identify behavioral patterns that correlate with patients'clinical status.Preliminary investigations have also shown that linguistic and behavioral clues from social media data and data extracted from the electronic medical records can be used to predict depression status.These other sources of data and recent advances in telepsychiatry can further enhance DP of the depressed patients.Success of DP endeavors depends on critical contributions from both psychiatric and engineering disciplines.The current review integrates important perspectives from both disciplines and discusses parameters for successful interdisciplinary collaborations.A clinically-relevant model for incorporating DP in clinical setting is presented.This model,based on investigations conducted by our group,delineates development of a depression prediction system and its integration in clinical setting to enhance depression diagnostics and inform the clinical decision making process.Benefits,challenges,and opportunities pertaining to clinical integration of DP of depression diagnostics are discussed from interdisciplinary perspectives.
文摘Novel and simplified bi-layer top-emitting white organic light emitting diodes(OLEDs)with dual co-host emitters have been simulated and analyzed.They consist of yellow-green emitting layer(EML)as electron transport layer(ETL)and blue EML as hole transport layer(HTL).Novelty of the device lies in simplification of tri-layer white OLED to a bi-layered device which is done by merging yellow-green EML with ETL and blue EML with HTL.The simulated devices show Commission Internationale de L’Eclairage(CIE)colour coordinates well within the emission range of white light.The results show that device A with 5,6,11,12-tetraphenylnaphthacene(rubrene)doped ETL has achieved the lowest luminance but longest excited state lifetime.Device D with tris-(8-hydroxyquinoline)aluminum:4-(dicyanomethylene)-2-t-butyle-6-(1,1,7,7-tetra-methyljulolidyl-9-enyl)4 H-pyran(Alq3:DCJTB)as ETL which emits yellow light and 2,7-bis[N,N-bis(4-methoxy-phenyl)amino]-9,9-spirobifluorene(MS-TPD):bis(2-methyl-8-quninolinato)-4-phenylphenolate alu-minium(BAlq)as HTL which is responsible for blue light emission is found to have best characteristics when compared to other simulated devices.It has a maximum luminance of 10000 cd/m2 and current efficiency of 15.25 cd/A,respectively,and CIE coordinates are at(0.329,0.319).The device is found to be compatible to be used in solid state lighting applications because of the low driving voltage of the device.
文摘To increase the current density of the hole only device, 1, 4, 5, 8, 9, 11-hexaazatriphenylene-hexacarbonitrile (HAT-CN) material has been inserted in the device at the indium tin oxide (ITO)/organic interface. Since HATCN molecule can withdraw electrons, it can alter electronic properties of the electrodes and hence inserted between the organic/metal interfaces. This paper deals with the optimization of the thickness of organic-metal layers to enhance the efficiency. Also, efforts have been made to increase the current density and reduce the operating voltage of the device. The material 2, 7-bis [N, N-bis (4- methoxy-phenyl) amino]-9, 9-spirobifluorene (Meo-Spiro-TPD) is used to simulate the hole only device because it is a thermally stable hole transport material. Simulated results shows that better current density values can be achieved compared to fabricated one by optimizing the organic metal layer thickness. The best optimized layer thickness of 22 nm for Alq3, 25 nm for *CBP doped with Ir(ppy)3, 9 nm for Meo-Spiro TPD and 4 nm for HAT-CN which results in current density of 0.12 A/cm2 with a reduction in operating voltage by approximately 2 V.
