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The RecQ DNA helicases: Jacks-of-all-trades or master-tradesmen?
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作者 neil hunter 《Cell Research》 SCIE CAS CSCD 2008年第3期328-330,共3页
Homologous recombination occurs when a damaged chromosome uses an intact homologous chromosome as a template for its repair. The main steps of recombination are most readily illustrated for the repair of a DNA doubles... Homologous recombination occurs when a damaged chromosome uses an intact homologous chromosome as a template for its repair. The main steps of recombination are most readily illustrated for the repair of a DNA doublestrand-break (DSB). First, DSB-ends are processed to form single-stranded tails, which assemble into nucleoprotein complexes comprising an oligomeric filament of a RecA-family protein (Rad51 in eukaryotes) and associated factors. Rad51 filaments catalyze homologous pairing and strand-exchange between a DSB-end and a double-stranded template to form a joint molecule intermediate. This structure allows de novo priming of DNA synthesis to restore sequences that were lost or damaged at the site of the original lesion. Recombination also underpins chromosome replication by facilitating the repair of broken replication forks. In this case, joint molecule formation allows rep- lication to reinitiate. At the final step of recombination, strand-exchange "Holliday" junctions that connect the involved chromosomes are resolved so that segregation can ensue. Joint molecule resolution can occur with one of two outcomes: a crossover, in which chromosome arms are exchanged; or a noncrossover without exchange. 展开更多
关键词 解螺旋酶 核蛋白 真核生物 细胞核
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Hyperresolution information and hyperresolution ignorance in modelling the hydrology of the land surface 被引量:6
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作者 Keith BEVEN Hannah CLOKE +2 位作者 Florian PAPPENBERGER Rob LAMB neil hunter 《Science China Earth Sciences》 SCIE EI CAS CSCD 2015年第1期25-35,共11页
There is a strong drive towards hyperresolution earth system models in order to resolve finer scales of motion in the atmosphere.The problem of obtaining more realistic representation of terrestrial fluxes of heat and... There is a strong drive towards hyperresolution earth system models in order to resolve finer scales of motion in the atmosphere.The problem of obtaining more realistic representation of terrestrial fluxes of heat and water,however,is not just a problem of moving to hyperresolution grid scales.It is much more a question of a lack of knowledge about the parameterisation of processes at whatever grid scale is being used for a wider modelling problem.Hyperresolution grid scales cannot alone solve the problem of this hyperresolution ignorance.This paper discusses these issues in more detail with specific reference to land surface parameterisations and flood inundation models.The importance of making local hyperresolution model predictions available for evaluation by local stakeholders is stressed.It is expected that this will be a major driving force for improving model performance in the future. 展开更多
关键词 hyperresolution models epistemic uncertainties models of everywhere communicating uncertainty flood risk
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