Electrical stimulation via invasive microelectrodes is commonly used to treat a wide range of neurological and psychiatric conditions.Despite its remarkable success,the stimulation performance is not sustainable since...Electrical stimulation via invasive microelectrodes is commonly used to treat a wide range of neurological and psychiatric conditions.Despite its remarkable success,the stimulation performance is not sustainable since the electrodes become encapsulated by gliosis due to foreign body reactions.Magnetic stimulation overcomes these limitations by eliminating the need for a metal-electrode contact.Here,we demonstrate a novel microfabricated solenoid inductor(80µm×40µm)with a magnetic core that can activate neuronal tissue.The characterization and proof-of-concept of the device raise the possibility that micromagnetic stimulation solenoids that are small enough to be implanted within the brain may prove to be an effective alternative to existing electrode-based stimulation devices for chronic neural interfacing applications.展开更多
基金This work was supported by the National Science Foundation under ECCS1533484 and NIH NINDS(UF1NS107694)Diamond sample fabrication was performed at the Center for Nanoscale Systems(CNS)at Harvard University,a member of the National Nanotechnology Coordinated Infrastructurewhich is supported by the NSF under ECCS-1541959.
文摘Electrical stimulation via invasive microelectrodes is commonly used to treat a wide range of neurological and psychiatric conditions.Despite its remarkable success,the stimulation performance is not sustainable since the electrodes become encapsulated by gliosis due to foreign body reactions.Magnetic stimulation overcomes these limitations by eliminating the need for a metal-electrode contact.Here,we demonstrate a novel microfabricated solenoid inductor(80µm×40µm)with a magnetic core that can activate neuronal tissue.The characterization and proof-of-concept of the device raise the possibility that micromagnetic stimulation solenoids that are small enough to be implanted within the brain may prove to be an effective alternative to existing electrode-based stimulation devices for chronic neural interfacing applications.