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Antimicrobial resistance containment in Africa:Moving beyond surveillance
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作者 Zikora Kizito Glory Anyaegbunam Ifeanyi Elibe Mba +6 位作者 Yandev Doowuese ngozi j.anyaegbunam Toluwalase Mba Fetuata Aminat Aina Vincent NnamdigadiChigor Emeka Innocent Nweze Emmanuel A.Ezea 《Biosafety and Health》 CAS CSCD 2024年第1期50-58,共9页
Worldwide,infections caused by drug‐resistant pathogens constitute a significant challenge threatening therapeutic efforts.According to the World Health Organization(WHO),antimicrobial resistance(AMR)ranks among the ... Worldwide,infections caused by drug‐resistant pathogens constitute a significant challenge threatening therapeutic efforts.According to the World Health Organization(WHO),antimicrobial resistance(AMR)ranks among the top 10 global public health threats.Organisms with a high rate of multiple host adaptivity,significant genetic diversity(multiple lineages),high virulence factors,and genetic exchange have been isolated from various sources(humans,animals,and the environment)even without exposure to prior antibiotics.Till now,the source of AMR and how resistant clones are selected in the environment remain largely elusive,and potential anthropogenic transmission has been reported in different studies.Various drug‐resistant pathogens,lineages,resistant clones,outbreak clusters,plasmid replicates,and genes that play a critical role in resistance dissemination have been identified.Maintenance of certain multidrug‐resistant(MDR)determinants has also been shown to enhance or support the propagation of MDR.So far,significant advances have been made in understanding the burden of AMR.However,overcoming AMR requires a holistic approach,as there is no single approach with sufficient precision to curb the threat.While strengthening AMR surveillance efforts is essential,as we have shown,there is also a need to intensify efforts to strengthen therapeutic interventions,especially in priority regions such as Africa.Herein,we discussed the burden of AMR and the dissemination of AMR in humans,animals,and the environment(non‐medical drivers).We further delved into the big questions on Africa and discussed how therapeutic interventions involving vaccines and other viable biomaterials could be pivotal in reducing the burden of AMR to the barest minimum. 展开更多
关键词 Antimicrobial resistance(AMR) BACTERIA SURVEILLANCE One Health Vaccines AFRICA
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