目的:探讨胆红素尿苷二磷酸葡萄糖醛酸转移酶1A1(UGT1A1)基因编码区的Gly71Arg(G71R)突变与越南新生儿黄疸的关系。方法:选择2017年1月至2018年6月在越南平顺省综合医院住院治疗的越南籍足月新生儿149例,根据是否患有高胆红素血症分为...目的:探讨胆红素尿苷二磷酸葡萄糖醛酸转移酶1A1(UGT1A1)基因编码区的Gly71Arg(G71R)突变与越南新生儿黄疸的关系。方法:选择2017年1月至2018年6月在越南平顺省综合医院住院治疗的越南籍足月新生儿149例,根据是否患有高胆红素血症分为病例组(99例)和对照组(无黄疸,50例)。采用PCR和DNA直接测序法检测两组UGT1A1 G71R突变频率,比较两组UGT1A1 G71R基因型分布及等位基因频率,观察病例组UGT1A1基因突变类型及其不同基因型患儿血清总胆红素水平。结果:病例组和对照组G71R突变等位基因频率分别为27.3%和5.0%,两组比较差异有统计学意义( P <0.01)。病例组G71R纯合子患儿血清总胆红素水平高于野生型及杂合子患儿(均 P <0.01)。结论:越南新生儿高胆红素血症的发生及其严重程度可能与UGT1A1 G71R基因突变有关。展开更多
In this paper, an analysis of adapted 20 extreme precipitation indices is calculated for a limited mountain area in southern Vietnam. The daily precipitation data from four stations in the period of more than 30 years...In this paper, an analysis of adapted 20 extreme precipitation indices is calculated for a limited mountain area in southern Vietnam. The daily precipitation data from four stations in the period of more than 30 years are selected. The statistical characteristics of maximum, minimum, mean, standard deviation, skewness, and kurtoris for each index are also analysed. A variety of distributions such as Normal, Lognormal, Beta, Gamma, Exponential, Loglogistic, and Johnson is used to find the best fit probability distribution for this area on the basic of the highest score. The scores are estimated based on the ranking of statistical goodness of fit test. The goodness of fit tests is the Anderson-Darling and Shapiro-Wilks tests. The best fit distribution for each index of extreme precipitation at each station is found out. Results revealed that the Johnson distribution is the best fit distribution to the data of very heavy precipitation days greater than 50 mm. Over a limited mountain area, it is difficult to fit a probability distribution to the precipitation fraction due to extremely wet days, number of extremely wet days, and number of extremely wet days when precipitation greater than 99 percentage. The lognormal, Johnson, and Loglogistic distribution are the best choices to fit most of the extreme precipitation indices over this area.展开更多
文摘目的:探讨胆红素尿苷二磷酸葡萄糖醛酸转移酶1A1(UGT1A1)基因编码区的Gly71Arg(G71R)突变与越南新生儿黄疸的关系。方法:选择2017年1月至2018年6月在越南平顺省综合医院住院治疗的越南籍足月新生儿149例,根据是否患有高胆红素血症分为病例组(99例)和对照组(无黄疸,50例)。采用PCR和DNA直接测序法检测两组UGT1A1 G71R突变频率,比较两组UGT1A1 G71R基因型分布及等位基因频率,观察病例组UGT1A1基因突变类型及其不同基因型患儿血清总胆红素水平。结果:病例组和对照组G71R突变等位基因频率分别为27.3%和5.0%,两组比较差异有统计学意义( P <0.01)。病例组G71R纯合子患儿血清总胆红素水平高于野生型及杂合子患儿(均 P <0.01)。结论:越南新生儿高胆红素血症的发生及其严重程度可能与UGT1A1 G71R基因突变有关。
文摘In this paper, an analysis of adapted 20 extreme precipitation indices is calculated for a limited mountain area in southern Vietnam. The daily precipitation data from four stations in the period of more than 30 years are selected. The statistical characteristics of maximum, minimum, mean, standard deviation, skewness, and kurtoris for each index are also analysed. A variety of distributions such as Normal, Lognormal, Beta, Gamma, Exponential, Loglogistic, and Johnson is used to find the best fit probability distribution for this area on the basic of the highest score. The scores are estimated based on the ranking of statistical goodness of fit test. The goodness of fit tests is the Anderson-Darling and Shapiro-Wilks tests. The best fit distribution for each index of extreme precipitation at each station is found out. Results revealed that the Johnson distribution is the best fit distribution to the data of very heavy precipitation days greater than 50 mm. Over a limited mountain area, it is difficult to fit a probability distribution to the precipitation fraction due to extremely wet days, number of extremely wet days, and number of extremely wet days when precipitation greater than 99 percentage. The lognormal, Johnson, and Loglogistic distribution are the best choices to fit most of the extreme precipitation indices over this area.
