Psoriasis is considered a systemic disease associated with metabolic abnormalities,and it is important to understand the mechanisms by which metabolism affects pathophysiological processes both holistically and system...Psoriasis is considered a systemic disease associated with metabolic abnormalities,and it is important to understand the mechanisms by which metabolism affects pathophysiological processes both holistically and systematically.Metabolites are closely related to disease phenotypes,especially in systemic diseases under multifactorial modulation.The emergence of metabolomics has provided information regarding metabolite changes in lesions and circulation and deepened our understanding of the association between metabolic reprogramming and psoriasis.Metabolomics has great potential for the development of effective biomarkers for clinical diagnosis,therapeutic monitoring,prediction of the efficacy of psoriasis management,and further discovery of new metabolism-based therapeutic targets.展开更多
Psoriasis is a chronic inflammatory disease that involves complex pathogenic interactions between the innate and adaptive immune systems,affecting approximately 2%of the population.In patients with pso riasi sis,s,the...Psoriasis is a chronic inflammatory disease that involves complex pathogenic interactions between the innate and adaptive immune systems,affecting approximately 2%of the population.In patients with pso riasi sis,s,the incidence of several important diseases is reportedly higher than that observed in the general population.Among them,car diovascular diseases(CVDs)are the most common cause of morbidity and mortality in patients with psoriasis.Hence,effective and safe treatments are critical in lowering cardiovascular risk in this patient group.展开更多
IntroductionMetabolic syndrome (MetS),also known as syndrome X,is a composite of multiple clinical symptoms and numerous postulated pathophysiological mechanisms that is becoming a common cause of mortality.Although M...IntroductionMetabolic syndrome (MetS),also known as syndrome X,is a composite of multiple clinical symptoms and numerous postulated pathophysiological mechanisms that is becoming a common cause of mortality.Although MetS is not a dermatological diagnosis,it is closely implicated in a number of dermatological pathological conditions,and several cutaneous manifestations can serve as a clinical indicator for impending MetS as well as facilitate an early diagnosis and appropriate therapy to prevent the longterm sequela of MetS.展开更多
Introduction Psoriasis is a chronic,immune-mediated inflammatory skin disease.The pathogenic characters of psoriasis are remarkable proliferation,unusual differentiation and immune activation of keratinocytes,accompan...Introduction Psoriasis is a chronic,immune-mediated inflammatory skin disease.The pathogenic characters of psoriasis are remarkable proliferation,unusual differentiation and immune activation of keratinocytes,accompanied with disorderly immune system[1].Psoriasis patients suffered from tremendous psychosocial burden,and remarkable reduction of physical activity and quality of life[2].展开更多
文摘Psoriasis is considered a systemic disease associated with metabolic abnormalities,and it is important to understand the mechanisms by which metabolism affects pathophysiological processes both holistically and systematically.Metabolites are closely related to disease phenotypes,especially in systemic diseases under multifactorial modulation.The emergence of metabolomics has provided information regarding metabolite changes in lesions and circulation and deepened our understanding of the association between metabolic reprogramming and psoriasis.Metabolomics has great potential for the development of effective biomarkers for clinical diagnosis,therapeutic monitoring,prediction of the efficacy of psoriasis management,and further discovery of new metabolism-based therapeutic targets.
文摘Psoriasis is a chronic inflammatory disease that involves complex pathogenic interactions between the innate and adaptive immune systems,affecting approximately 2%of the population.In patients with pso riasi sis,s,the incidence of several important diseases is reportedly higher than that observed in the general population.Among them,car diovascular diseases(CVDs)are the most common cause of morbidity and mortality in patients with psoriasis.Hence,effective and safe treatments are critical in lowering cardiovascular risk in this patient group.
文摘IntroductionMetabolic syndrome (MetS),also known as syndrome X,is a composite of multiple clinical symptoms and numerous postulated pathophysiological mechanisms that is becoming a common cause of mortality.Although MetS is not a dermatological diagnosis,it is closely implicated in a number of dermatological pathological conditions,and several cutaneous manifestations can serve as a clinical indicator for impending MetS as well as facilitate an early diagnosis and appropriate therapy to prevent the longterm sequela of MetS.
基金CAMS Innovation Fund for Medical Sciences(No.CIFMS-2017-I2M-1-017)the Natural Science Foundation of Jiangsu Province(No.BK20161123).
文摘Introduction Psoriasis is a chronic,immune-mediated inflammatory skin disease.The pathogenic characters of psoriasis are remarkable proliferation,unusual differentiation and immune activation of keratinocytes,accompanied with disorderly immune system[1].Psoriasis patients suffered from tremendous psychosocial burden,and remarkable reduction of physical activity and quality of life[2].
