The attenuated anaerobic bacterium Clostridium novyi-NT(C.novyi-NT)is known for its ability to precisely germinate in and eradicate treatment-resistant hypoxic tumors in various experimental animal models and spontane...The attenuated anaerobic bacterium Clostridium novyi-NT(C.novyi-NT)is known for its ability to precisely germinate in and eradicate treatment-resistant hypoxic tumors in various experimental animal models and spontaneously occurring canine sarcomas.In this article,we review the therapeutic and toxicologic aspects of C.novyi-NT therapy,key challenges and limitations,and promising strategies to optimize its performance via recombinant DNA technology and immunotherapeutic approaches,to establish C.novyi-NT as an essential tool in cancer therapy.展开更多
基金This work was supported by the Francis S.Collins Scholars Program in Neurofibromatosis Clinical and Translational Research(V.S.)the Sol Goldman Pancreatic Cancer Research Center(N.J.R.),NIH/NCI K99-CA190889(N.J.R.)1R03CA178118-01A1(R-Y.B.),as well as BioMed Valley Discoveries Inc.(S.Z.),the Virginia and D.K.Ludwig Fund for Cancer Research(S.Z.),and NIH/NCI CA062924(S.Z.).
文摘The attenuated anaerobic bacterium Clostridium novyi-NT(C.novyi-NT)is known for its ability to precisely germinate in and eradicate treatment-resistant hypoxic tumors in various experimental animal models and spontaneously occurring canine sarcomas.In this article,we review the therapeutic and toxicologic aspects of C.novyi-NT therapy,key challenges and limitations,and promising strategies to optimize its performance via recombinant DNA technology and immunotherapeutic approaches,to establish C.novyi-NT as an essential tool in cancer therapy.
