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Stress granules: friend or foe in neurodegenerative disorders?
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作者 Shanshan Xu nico p.dantuma 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第2期403-404,共2页
Neurodegenerative diseases,such as Alzheimer’s disease,Parkinson’s disease,and amyotrophic lateral sclerosis,despite the diversity in clinical symptoms,share a striking feature at the cellular level:the accumulation... Neurodegenerative diseases,such as Alzheimer’s disease,Parkinson’s disease,and amyotrophic lateral sclerosis,despite the diversity in clinical symptoms,share a striking feature at the cellular level:the accumulation of insoluble aggregates of misfolded proteins that are sequestered in intraneuronal inclusion bodies.Besides mutations in disease-associated proteins that render them aggregation-prone,the decline of protein homeostasis(i.e.proteostasis)with aging is also believed to be a contributing factor to the accumulation of protein aggregates. 展开更多
关键词 DEGENERATIVE HOMEOSTASIS CLINICAL
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