In this work, Bioactive-functionalized interpenetrating network (IPNs) hydrogel (BIOF-INPs) were prepared and investigated in vitro for the free radical detection/defense, therapeutic release as well as shear bond str...In this work, Bioactive-functionalized interpenetrating network (IPNs) hydrogel (BIOF-INPs) were prepared and investigated in vitro for the free radical detection/defense, therapeutic release as well as shear bond strength to dentine, ability to re-mineralize surface of the dentin after application of these bio-inspired materials using a biologically inspired mineralization process in vitro as well as investigating antimicrobial properties of the BIOF-INPs against S. aureous. The aim of this investigation was to evaluate the suitability and flexibility of the designer materials to act as an “in vitro” probe to gain insights into molecular origin of TMD and associated disorders.展开更多
Restorative materials in the new era aim to be “bioactive” and long-lasting. The purpose of the study was to design and evaluate novel chitosan hydrogels containing melatonin and/or propolis (antioxidant containing ...Restorative materials in the new era aim to be “bioactive” and long-lasting. The purpose of the study was to design and evaluate novel chitosan hydrogels containing melatonin and/or propolis (antioxidant containing material), nystatin (antifungal), naproxen (pain relieve medication) and combinations thereof (chitosan-H-melatonin, chitosan-H-melatonin-naproxen, chitosan-H-propolis, chitosan-H-propolisnaproxen, chitosan-H-naproxen-propolis-melatonin, Chitosan/Propolis/Nystatin, Chitosan/Melatonin/Propolis/Nystatin, Chitosan/Propolis/BSA/Nystatin, Chitosan/Melatonin/BSA/Nystatin) as functional additive prototypes for further development of “dual function restorative materials”, to determine their effect on the dentin bond strength of a composite, to evaluate stability of the encapsulated antioxidants as well as evaluate antimicrobial properties of the selected group of “designer” functional materials. Materials and Methods: The above mentioned hydrogels were prepared by dispersion of the corresponding component in glycerol and acetic acid with the addition of chitosan gelling agent. The surface morphology (SEM), drug-polymer solid state interaction (FT-IR spectroscopy), released behaviours (physiological pH and also in acidic conditions), stability of the therapeutic agent-antioxidant-chitosan and the effect of the hydrogels on the shear bond strength of dentin were also evaluated. Results: The release of naproxen confers the added benefit of synergistic action of a functional therapeutic delivery when comparing the newly designed chitosan-based hydrogel restorative materials to the commercially available products alone. Neither the release of naproxen or the antioxidant stability was affected by storage over a 6-month period. The hydrogel formulations have a uniform distribution of drug content, homogenous texture and yellow colour (SEM study). All chitosan dentin treated hydrogels gave significantly展开更多
文摘In this work, Bioactive-functionalized interpenetrating network (IPNs) hydrogel (BIOF-INPs) were prepared and investigated in vitro for the free radical detection/defense, therapeutic release as well as shear bond strength to dentine, ability to re-mineralize surface of the dentin after application of these bio-inspired materials using a biologically inspired mineralization process in vitro as well as investigating antimicrobial properties of the BIOF-INPs against S. aureous. The aim of this investigation was to evaluate the suitability and flexibility of the designer materials to act as an “in vitro” probe to gain insights into molecular origin of TMD and associated disorders.
文摘Restorative materials in the new era aim to be “bioactive” and long-lasting. The purpose of the study was to design and evaluate novel chitosan hydrogels containing melatonin and/or propolis (antioxidant containing material), nystatin (antifungal), naproxen (pain relieve medication) and combinations thereof (chitosan-H-melatonin, chitosan-H-melatonin-naproxen, chitosan-H-propolis, chitosan-H-propolisnaproxen, chitosan-H-naproxen-propolis-melatonin, Chitosan/Propolis/Nystatin, Chitosan/Melatonin/Propolis/Nystatin, Chitosan/Propolis/BSA/Nystatin, Chitosan/Melatonin/BSA/Nystatin) as functional additive prototypes for further development of “dual function restorative materials”, to determine their effect on the dentin bond strength of a composite, to evaluate stability of the encapsulated antioxidants as well as evaluate antimicrobial properties of the selected group of “designer” functional materials. Materials and Methods: The above mentioned hydrogels were prepared by dispersion of the corresponding component in glycerol and acetic acid with the addition of chitosan gelling agent. The surface morphology (SEM), drug-polymer solid state interaction (FT-IR spectroscopy), released behaviours (physiological pH and also in acidic conditions), stability of the therapeutic agent-antioxidant-chitosan and the effect of the hydrogels on the shear bond strength of dentin were also evaluated. Results: The release of naproxen confers the added benefit of synergistic action of a functional therapeutic delivery when comparing the newly designed chitosan-based hydrogel restorative materials to the commercially available products alone. Neither the release of naproxen or the antioxidant stability was affected by storage over a 6-month period. The hydrogel formulations have a uniform distribution of drug content, homogenous texture and yellow colour (SEM study). All chitosan dentin treated hydrogels gave significantly
