The Karakorum Fault zone(KFZ)plays an important role in understanding the formation,evolvement and deformation of the Tibetan Plateau.The high-T dextral shearing metamorphic rocks,e.g.,mylonites or mylonitized gneisse...The Karakorum Fault zone(KFZ)plays an important role in understanding the formation,evolvement and deformation of the Tibetan Plateau.The high-T dextral shearing metamorphic rocks,e.g.,mylonites or mylonitized gneisses-granites,locally crop out along the southeastern part of the KFZ in the Ayila Ri’gyüRange area.The SHRIMP U-Pb dating of the syn-kinematic crystallized zircons indicates that the initial age of the KFZ is^27 Ma,~10 Ma older than previous results.The extensive high-T dextral shearing along the KFZ started at least at 27-20 Ma,accompanied by the syn-kinematic emplacement of leuco-granites.Deformation and concomitant fluid circulation during shearing most likely occurred as early as at 25-13 Ma.The KFZ probably grew from southeast to northwest along the fault as a result of continuous convergence between the India plate and Eurasia plate.展开更多
Indolent B-cell lymphomas are a group of incurable cancers of the elderly that encompass various entities,such as chronic lymphocytic leukemia(CLL),follicular lymphoma(FL),and marginal zone lymphoma(MZL).All indolent ...Indolent B-cell lymphomas are a group of incurable cancers of the elderly that encompass various entities,such as chronic lymphocytic leukemia(CLL),follicular lymphoma(FL),and marginal zone lymphoma(MZL).All indolent lymphomas may evolve towards aggressive transformation with an increased proliferation index and decreased tumor doubling time.This transformation,which is called Richter’s syndrome in CLL,is associated with an aggressive clinical course and poor survival.At least in CLL,transformation of an indolent B-cell clone is molecularly different from that of de novo diffuse large B-cell lymphomas.1 Aging is known to be associated with immune decline,with increased inflammation,decreased immune surveillance and increased onset of malignancies among the consequences.2 Progression of indolent B-cell lymphomas is likely to be associated with escape from immune surveillance.展开更多
基金Supported by the National Natural Science Foundation of China(Grant Nos.40272096 and 40572122)and China Geological Survey(Grant No.1212010610105)
文摘The Karakorum Fault zone(KFZ)plays an important role in understanding the formation,evolvement and deformation of the Tibetan Plateau.The high-T dextral shearing metamorphic rocks,e.g.,mylonites or mylonitized gneisses-granites,locally crop out along the southeastern part of the KFZ in the Ayila Ri’gyüRange area.The SHRIMP U-Pb dating of the syn-kinematic crystallized zircons indicates that the initial age of the KFZ is^27 Ma,~10 Ma older than previous results.The extensive high-T dextral shearing along the KFZ started at least at 27-20 Ma,accompanied by the syn-kinematic emplacement of leuco-granites.Deformation and concomitant fluid circulation during shearing most likely occurred as early as at 25-13 Ma.The KFZ probably grew from southeast to northwest along the fault as a result of continuous convergence between the India plate and Eurasia plate.
基金The group of J Feuillard is supported by grants from the Ligue Nationale contre le Cancer(Equipe Labellisee Ligue),the Institut National contre le Cancer(INCa),the Comité Orientation Recherche Cancer(CORC),the Limousin Region and the Haute Vienne and Correze comitees of the Ligue Nationale contre le Cancer and by the Lyons Club of CorrezeU Zimber-Strobl was supported by the German ResearchFoundation(SFB 1243,TP-A13).
文摘Indolent B-cell lymphomas are a group of incurable cancers of the elderly that encompass various entities,such as chronic lymphocytic leukemia(CLL),follicular lymphoma(FL),and marginal zone lymphoma(MZL).All indolent lymphomas may evolve towards aggressive transformation with an increased proliferation index and decreased tumor doubling time.This transformation,which is called Richter’s syndrome in CLL,is associated with an aggressive clinical course and poor survival.At least in CLL,transformation of an indolent B-cell clone is molecularly different from that of de novo diffuse large B-cell lymphomas.1 Aging is known to be associated with immune decline,with increased inflammation,decreased immune surveillance and increased onset of malignancies among the consequences.2 Progression of indolent B-cell lymphomas is likely to be associated with escape from immune surveillance.
