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S-acylation of Ca^(2+)transport proteins in cancer
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作者 Sana Kouba nicolas demaurex 《Chronic Diseases and Translational Medicine》 CAS CSCD 2024年第4期263-280,共18页
Alterations in cellular calcium(Ca^(2+))signals have been causally associated with the development and progression of human cancers.Cellular Ca^(2+)signals are generated by channels,pumps,and exchangers that move Ca^(... Alterations in cellular calcium(Ca^(2+))signals have been causally associated with the development and progression of human cancers.Cellular Ca^(2+)signals are generated by channels,pumps,and exchangers that move Ca^(2+)ions across membranes and are decoded by effector proteins in the cytosol or in organelles.S-acylation,the reversible addition of 16-carbon fatty acids to proteins,modulates the activity of Ca^(2+)transporters by altering their affinity for lipids,and enzymes mediating this reversible post-translational modification have also been linked to several types of cancers.Here,we compile studies reporting an association between Ca^(2+)transporters or S-acylation enzymes with specific cancers,as well as studies reporting or predicting the S-acylation of Ca^(2+)transporters.We then discuss the potential role of S-acylation in the oncogenic potential of a subset of Ca^(2+)transport proteins involved in cancer. 展开更多
关键词 Ca^(2+)signaling Ca^(2+)transport proteins CANCER S-ACYLATION S-palmitoylation
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