Two new N-methyladenine-containing diterpenes,nemoechines F（l）and G（2）,were isolated from the South China Sea sponge Agelas aff.nemoechinata.The structures were assigned on the basis of spectroscopic date.Compound...Two new N-methyladenine-containing diterpenes,nemoechines F（l）and G（2）,were isolated from the South China Sea sponge Agelas aff.nemoechinata.The structures were assigned on the basis of spectroscopic date.Compound 2 showed weak activity against Jurkat cell lines with IC50 of 17.1 μmol/L展开更多
Comprehensive Summary Seven new kalihinene diterpenoids,kalihioxepanes A-G(1-7)bearing a rare oxepane ring,were isolated from sponge Acanthella cavernosa collected from the South China Sea.The structures and absolute ...Comprehensive Summary Seven new kalihinene diterpenoids,kalihioxepanes A-G(1-7)bearing a rare oxepane ring,were isolated from sponge Acanthella cavernosa collected from the South China Sea.The structures and absolute configurations were elucidated by comprehensive spectroscopic analysis,single crystal X-ray diffraction,and quantum chemical calculation methods.Kalihioxepane A(1)displayed strong cytotoxicity against H69 and K562 tumor cells,while kalihioxepane B(2)showed moderate cytotoxicity against K562 cells.展开更多
Main observation and conclusion Two new bis-quinolizidine alkaloids,neopetrosiasins A(1)and B(2),possessing cis-and trans-quinolizidine nuclei,one known related analogue petrosin(3)and three known xestospongins(4-6),w...Main observation and conclusion Two new bis-quinolizidine alkaloids,neopetrosiasins A(1)and B(2),possessing cis-and trans-quinolizidine nuclei,one known related analogue petrosin(3)and three known xestospongins(4-6),were isolated from the South China Sea sponge Neopetrosia chaliniformis.展开更多
Three new non-brominated pyrrole alkaloids,nakamurines A-C（1-3） were isolated from the South China Sea sponge Agelas nakamurai.Their structures were elucidated on the basis of spectroscopic data.Compound 2 showed we...Three new non-brominated pyrrole alkaloids,nakamurines A-C（1-3） were isolated from the South China Sea sponge Agelas nakamurai.Their structures were elucidated on the basis of spectroscopic data.Compound 2 showed weak antimicrobial activity against Candida albicans with MIC of 60μg/mL.展开更多
The dietary relationship study between marine sponge Xestospongia sp.and its nudibranch predators Jorunna funebris based on the discovery of isoquinolinequinones has long been studied.In this study,chemical investigat...The dietary relationship study between marine sponge Xestospongia sp.and its nudibranch predators Jorunna funebris based on the discovery of isoquinolinequinones has long been studied.In this study,chemical investigation of the sponge Xestospongia sp.and nudibranch J.funebris from the South China Sea yielded a new marine alkaloid neopetroside C(1),together with nine known alkaloids(2-10).The chemical structures of all the compounds were elucidated by extensive spectroscopic analysis.Neopetroside C(1)featured a riboside of nicotinic acid with a rareα-N glycosildic linkage and an acyl residue of(Z)-2-methylbut-2-enoic acid attached to C-5′.The plausible chemical ecology relationship between sponge Xestospongia sp.and its nudibranch predator J.funebris was proposed based on the biogenetic relationship of the common marine alkaloids.The observation of two structural fragments,(Z)-2-methylbut-2-enoyloxy and trigonelline groups in both sponge and nudibranch,indicated that nudibranch might uptake chemicals from sponge and then modify and transform them into chemical weapons to defend against predators.展开更多
基金supported by the National Natural Science Foundation of China (Nos. 41376142 and 41476107)NSFCShandong Joint Fund for Marine Science Research Centers (No. U1406402)
文摘Two new N-methyladenine-containing diterpenes,nemoechines F（l）and G（2）,were isolated from the South China Sea sponge Agelas aff.nemoechinata.The structures were assigned on the basis of spectroscopic date.Compound 2 showed weak activity against Jurkat cell lines with IC50 of 17.1 μmol/L
基金This work was supported by the National Natural Science Foundation of China(Nos.U2006204,41776136,2181101213,81991522,and 41876161)。
文摘Comprehensive Summary Seven new kalihinene diterpenoids,kalihioxepanes A-G(1-7)bearing a rare oxepane ring,were isolated from sponge Acanthella cavernosa collected from the South China Sea.The structures and absolute configurations were elucidated by comprehensive spectroscopic analysis,single crystal X-ray diffraction,and quantum chemical calculation methods.Kalihioxepane A(1)displayed strong cytotoxicity against H69 and K562 tumor cells,while kalihioxepane B(2)showed moderate cytotoxicity against K562 cells.
基金This research work was financially supported by the National Natural Science Foundation of China(Nos.81991521,82022069,42076099,41830535)the Shanghai Rising-Star Program(No.20QA1411100)+1 种基金the National Key Research and Development Program of China(No.2018YFC0310903)the Taishan Scholars Program,China.Bao Chen is thankful for the financial support of Syngenta-OUC-PhD Studentship Project.
文摘Main observation and conclusion Two new bis-quinolizidine alkaloids,neopetrosiasins A(1)and B(2),possessing cis-and trans-quinolizidine nuclei,one known related analogue petrosin(3)and three known xestospongins(4-6),were isolated from the South China Sea sponge Neopetrosia chaliniformis.
基金supported by the National Natural Science Foundation of China(Nos.41376142,41476107,41522605)NSFC-Shandong Joint Fund for Marine Science Research Centers(Nos.U1406402)+1 种基金AoShan Talents Program Supported by Qingdao National Laboratory for Marine Science and Technology(No.2015ASTP)Science and Technology Program of Applied Basic Research Projects of Qingdao Municipal Government(No.14-2-4-32-jch)
文摘Three new non-brominated pyrrole alkaloids,nakamurines A-C（1-3） were isolated from the South China Sea sponge Agelas nakamurai.Their structures were elucidated on the basis of spectroscopic data.Compound 2 showed weak antimicrobial activity against Candida albicans with MIC of 60μg/mL.
基金This research work was financially supported by the National Natural Science Foundation of China(NSFC)(Nos.8202290170,81991521,42076099,41676073)the NSFC/CNRS joint project(No.81811530284),and the SKLDR/SIMM Project(No.SIMM1903ZZ-04)X-W Li is also thankful for the Shanghai Rising-Star Program(No.20QA1411100),SA-SIBS Scholarship Program.
文摘The dietary relationship study between marine sponge Xestospongia sp.and its nudibranch predators Jorunna funebris based on the discovery of isoquinolinequinones has long been studied.In this study,chemical investigation of the sponge Xestospongia sp.and nudibranch J.funebris from the South China Sea yielded a new marine alkaloid neopetroside C(1),together with nine known alkaloids(2-10).The chemical structures of all the compounds were elucidated by extensive spectroscopic analysis.Neopetroside C(1)featured a riboside of nicotinic acid with a rareα-N glycosildic linkage and an acyl residue of(Z)-2-methylbut-2-enoic acid attached to C-5′.The plausible chemical ecology relationship between sponge Xestospongia sp.and its nudibranch predator J.funebris was proposed based on the biogenetic relationship of the common marine alkaloids.The observation of two structural fragments,(Z)-2-methylbut-2-enoyloxy and trigonelline groups in both sponge and nudibranch,indicated that nudibranch might uptake chemicals from sponge and then modify and transform them into chemical weapons to defend against predators.
