Polymers are being used extensively in drug delivery due to their surface and bulk properties. They are being used in drug formulations and in drug delivery devices. These drug delivery devices may be in the form of i...Polymers are being used extensively in drug delivery due to their surface and bulk properties. They are being used in drug formulations and in drug delivery devices. These drug delivery devices may be in the form of implants for controlled drug delivery. Polymers used in colloidal drug carrier systems, consisting of small particles, show great advantage in drug delivery systems because of optimized drug loading and releasing property. Polymeric nano particulate systems are available in wide variety and have established chemistry. Non toxic, biodegradable and biocompatible polymers are available. Some nano particulate polymeric systems possess ability to cross blood brain barrier. They offer protection against chemical degradation. Smart polymers are responsive to atmospheric stimulus like change in temperature;pressure, pH etc. thus are extremely beneficial for targeted drug delivery. Some polymeric systems conjugated with antibodies/specific biomarkers help in detecting molecular targets specifically in cancers. Surface coating with thiolated PEG, Silica-PEG improves water solubility and photo stability. Surface modification of drug carriers e.g. attachment with PEG or dextran to the lipid bilayer increases their blood circulation time. Polymer drug conjugates such as Zoladex, Lupron Depot, On Caspar PEG intron are used in treatment of prostate cancer and lymphoblastic leukemia. Polymeric Drug Delivery systems are being utilized for controlled drug delivery assuring patient compliance.展开更多
Background The uncanny valley hypothesis states that users may experience discomfort when inter-acting with almost human-like artificial characters.Advancements in artificial intelligence,robotics,and computer graphic...Background The uncanny valley hypothesis states that users may experience discomfort when inter-acting with almost human-like artificial characters.Advancements in artificial intelligence,robotics,and computer graphics have led to the development of life-like virtual humans and humanoid robots.Revisiting this hypothesis is necessary to check whether they positively or negatively affect the current population,who are highly accustomed to the latest technologies.Methods In this study,we present a unique evaluation of the uncanny valley hypothesis by allowing participants to interact live with four humanoid robots that have varying levels of human-likeness.Each participant completed a survey questionnaire to evaluate the affinity of each robot.Additionally,we used deep learning methods to quantify the participants’emotional states using multimodal cues,including visual,audio,and text cues,by recording the participant-robot interactions.Results Multi-modal analysis and surveys provided interesting results and insights into the uncanny valley hypothesis.展开更多
文摘Polymers are being used extensively in drug delivery due to their surface and bulk properties. They are being used in drug formulations and in drug delivery devices. These drug delivery devices may be in the form of implants for controlled drug delivery. Polymers used in colloidal drug carrier systems, consisting of small particles, show great advantage in drug delivery systems because of optimized drug loading and releasing property. Polymeric nano particulate systems are available in wide variety and have established chemistry. Non toxic, biodegradable and biocompatible polymers are available. Some nano particulate polymeric systems possess ability to cross blood brain barrier. They offer protection against chemical degradation. Smart polymers are responsive to atmospheric stimulus like change in temperature;pressure, pH etc. thus are extremely beneficial for targeted drug delivery. Some polymeric systems conjugated with antibodies/specific biomarkers help in detecting molecular targets specifically in cancers. Surface coating with thiolated PEG, Silica-PEG improves water solubility and photo stability. Surface modification of drug carriers e.g. attachment with PEG or dextran to the lipid bilayer increases their blood circulation time. Polymer drug conjugates such as Zoladex, Lupron Depot, On Caspar PEG intron are used in treatment of prostate cancer and lymphoblastic leukemia. Polymeric Drug Delivery systems are being utilized for controlled drug delivery assuring patient compliance.
基金Supported by the National Research Foundation,Singapore under its International Research Centers in Singapore Funding InitiativeInstitute for Media Innovation,Nanyang Technological University(IMI-NTU)。
文摘Background The uncanny valley hypothesis states that users may experience discomfort when inter-acting with almost human-like artificial characters.Advancements in artificial intelligence,robotics,and computer graphics have led to the development of life-like virtual humans and humanoid robots.Revisiting this hypothesis is necessary to check whether they positively or negatively affect the current population,who are highly accustomed to the latest technologies.Methods In this study,we present a unique evaluation of the uncanny valley hypothesis by allowing participants to interact live with four humanoid robots that have varying levels of human-likeness.Each participant completed a survey questionnaire to evaluate the affinity of each robot.Additionally,we used deep learning methods to quantify the participants’emotional states using multimodal cues,including visual,audio,and text cues,by recording the participant-robot interactions.Results Multi-modal analysis and surveys provided interesting results and insights into the uncanny valley hypothesis.
