New and sophisticated endovascular devices, such as drug-eluting stents(DES)and drug-coated balloons(DCB), provide targeted drug delivery to affected vessels. The invention of these devices has made it possible to add...New and sophisticated endovascular devices, such as drug-eluting stents(DES)and drug-coated balloons(DCB), provide targeted drug delivery to affected vessels. The invention of these devices has made it possible to address the reparative cascade of arterial wall injury following balloon angioplasty that results in restenosis. DESs were first used for the treatment of infrapopliteal lesions almost 20 years ago. More recently, however, DCB technology is being investigated to improve outcomes of endovascular below-the-knee arterial procedures, avoiding the need for a metallic scaffold. Today, level IA evidence supports the use of infrapopliteal DES for short to medium length lesions,although robust evidence that justifies the use of DCBs in this anatomical area is missing. This review summarizes and discusses all available data on infrapopliteal drug-elution devices and highlights the most promising future perspectives.展开更多
Colorectal cancer(CRC)is the second most common cause of cancer death in the developed world and the third most common malignancy worldwide,with more than 1 million people affected.Approximately half of this populatio...Colorectal cancer(CRC)is the second most common cause of cancer death in the developed world and the third most common malignancy worldwide,with more than 1 million people affected.Approximately half of this population develops colorectal liver metastases(CLM)with a significant increase in morbidity and mortality,yet only a minority of these patients(10-15%)can undergo hepatectomy(1).Image-guided percutaneous thermal ablation(TA)destroys cancer cells by delivering heat directly into the tumor using radiofrequency(RFA)or microwave(MWA)energy,via special needles/electrodes.展开更多
文摘New and sophisticated endovascular devices, such as drug-eluting stents(DES)and drug-coated balloons(DCB), provide targeted drug delivery to affected vessels. The invention of these devices has made it possible to address the reparative cascade of arterial wall injury following balloon angioplasty that results in restenosis. DESs were first used for the treatment of infrapopliteal lesions almost 20 years ago. More recently, however, DCB technology is being investigated to improve outcomes of endovascular below-the-knee arterial procedures, avoiding the need for a metallic scaffold. Today, level IA evidence supports the use of infrapopliteal DES for short to medium length lesions,although robust evidence that justifies the use of DCBs in this anatomical area is missing. This review summarizes and discusses all available data on infrapopliteal drug-elution devices and highlights the most promising future perspectives.
文摘Colorectal cancer(CRC)is the second most common cause of cancer death in the developed world and the third most common malignancy worldwide,with more than 1 million people affected.Approximately half of this population develops colorectal liver metastases(CLM)with a significant increase in morbidity and mortality,yet only a minority of these patients(10-15%)can undergo hepatectomy(1).Image-guided percutaneous thermal ablation(TA)destroys cancer cells by delivering heat directly into the tumor using radiofrequency(RFA)or microwave(MWA)energy,via special needles/electrodes.
