Purpose: To investigate the effects of photodynamic therapy (PDT) on subfoveal choroidal neovascularization (CNV) in age-related macular degeneration (AMD) i n a Swedish patient material with smaller lesions than thos...Purpose: To investigate the effects of photodynamic therapy (PDT) on subfoveal choroidal neovascularization (CNV) in age-related macular degeneration (AMD) i n a Swedish patient material with smaller lesions than those investigated in the TAP (Treatment of Age-related Macular Degeneration with Photodynamic Therapy) and VIP (Verteporfin in Photodynamic Therapy) Studies. Methods: Photodynamic the rapy with verteporfin was performed according to the results and recommendations of the TAP and VIP Studies. The patients were followed up for 12 months and ret reatment was performed every 12 weeks when leakage from CNV was present. Of the 100 eyes in the first 100 patients with a follow-up period of 12 months, 59%ha d a predominantly classic lesion, 36%had an occult-only lesion and 5%had a mi nimally classic lesion. The greatest linear dimension (GLD) was ≤3 NIPS (Macula r Photocoagulation Study) disc diameters (DD) in 73%, 39%and 20%of lesions, r espectively, for the three groups. The actual lesion area was ≤3 MPS disc areas (DA) in 85%, 50%and 40%of lesions, respectively. There was a positive correl ation (P < 0.05) between the duration of symptoms and GLD, as well as between th e duration of symptoms and the lesion area (P < 0.02). Results: At 12 months, vi sual acuity had remained stable or increased by ≥3 lines (ETDRS) in 61%of pati ents with predominantly classic lesions, in 61%of patients with occult-only le sions and in 60%of patients with minimally classic lesions. Leakage had stopped after 2.9 ±0.9 treatments in 77%of the total group of patients. Conclusion: T he visual outcome was comparable to those of the TAP and VIP Studies (P > 0.3). Regarding the effect on leakage, however, our results are far better than those of the TAP and VIP Studies. The proportion of patients in which leakage had stop ped was almost three times that of the TAP (27%) and VIP (26%) Studies. It see ms likely that this difference was caused by the fact that the lesions in our st udy were much smaller, on average, than those in the TAP and VIP Studies.展开更多
文摘Purpose: To investigate the effects of photodynamic therapy (PDT) on subfoveal choroidal neovascularization (CNV) in age-related macular degeneration (AMD) i n a Swedish patient material with smaller lesions than those investigated in the TAP (Treatment of Age-related Macular Degeneration with Photodynamic Therapy) and VIP (Verteporfin in Photodynamic Therapy) Studies. Methods: Photodynamic the rapy with verteporfin was performed according to the results and recommendations of the TAP and VIP Studies. The patients were followed up for 12 months and ret reatment was performed every 12 weeks when leakage from CNV was present. Of the 100 eyes in the first 100 patients with a follow-up period of 12 months, 59%ha d a predominantly classic lesion, 36%had an occult-only lesion and 5%had a mi nimally classic lesion. The greatest linear dimension (GLD) was ≤3 NIPS (Macula r Photocoagulation Study) disc diameters (DD) in 73%, 39%and 20%of lesions, r espectively, for the three groups. The actual lesion area was ≤3 MPS disc areas (DA) in 85%, 50%and 40%of lesions, respectively. There was a positive correl ation (P < 0.05) between the duration of symptoms and GLD, as well as between th e duration of symptoms and the lesion area (P < 0.02). Results: At 12 months, vi sual acuity had remained stable or increased by ≥3 lines (ETDRS) in 61%of pati ents with predominantly classic lesions, in 61%of patients with occult-only le sions and in 60%of patients with minimally classic lesions. Leakage had stopped after 2.9 ±0.9 treatments in 77%of the total group of patients. Conclusion: T he visual outcome was comparable to those of the TAP and VIP Studies (P > 0.3). Regarding the effect on leakage, however, our results are far better than those of the TAP and VIP Studies. The proportion of patients in which leakage had stop ped was almost three times that of the TAP (27%) and VIP (26%) Studies. It see ms likely that this difference was caused by the fact that the lesions in our st udy were much smaller, on average, than those in the TAP and VIP Studies.
