Objective:To explore the changes of immune function and serum inflammatory cytokines levels in patients with primary biliary cirrhosis.Methods: Fifty-five patients with primary biliary cirrhosis who were treated in ou...Objective:To explore the changes of immune function and serum inflammatory cytokines levels in patients with primary biliary cirrhosis.Methods: Fifty-five patients with primary biliary cirrhosis who were treated in our hospital from June 2015 to January 2017 were selected as the observation group and 55 healthy subjects were selected as the control group. The liver function, immune function and inflammatory cytokines levels were measured.Results: The levels of ALT, AST and TBIL in observation group were (103.2±6.14) U/L, (96.07±3.48) U/L and (86.60±8.25)μmol/L respectively, which were significantly higher than those in control group, the difference was statistically significant;The levels of IL-6, IL-8, IL-10 and TNF-αin the observation group were (68.47±10.70) pg/mL, (881.49±94.50) pg/mL, (50.49±5.22) pg/mL and (429.45±96.13) pg/mL, which were significantly higher than those in healthy controls;The percentage of CD3+, CD4+, CD8+ and CD4+/CD8+ in the observation group were (68.73±7.21)%, (42.31±1.06)%, (20.27±1.1)% and (2.35±0.08)%, and the CD3+, CD4+, CD4+/CD8+ levels were obviously higher than control group. There was no significant difference in CD8+ level compared with control group.Conclusion: Patients with primary biliary cirrhosis have abnormal liver function, immune dysfunction and inflammatory response, which should be timely monitored in clinical treatment so as to treat the disease more effectively.展开更多
A study on ultrahigh strength steel plate subjected to novel thermo-mechanical control process was presented. The mechanical properties examination showed that the investigated steel exhibited excellent combination of...A study on ultrahigh strength steel plate subjected to novel thermo-mechanical control process was presented. The mechanical properties examination showed that the investigated steel exhibited excellent combination of ultra-high strength（ 2 200 MPa） and toughness（ 26 J）. The microstructure of the experimental steel was observed by scanning electron microscope and transmission electron microscope. Desired martensitic lath with width of about 180- 250 nm was obtained. Nanostructured carbide precipitates with sizes of 20-50 nm,which contained Nb,Ti and Mo,were observed in the lath martensitic microstructure,and confirmed to be MC-type carbides with B1 structure by means of selected area electron diffraction.The compositional characteristics revealed by energy dispersive X-ray spectrometer mapping implied that the carbide forming elements Nb,Ti and Mo distributed in the precipitates evenly. Three-dimensional atom probe tomography reconstruction further indicated that Mo incorporated into the precipitates without enrichment in the carbide-matrix interface and probably substituted for Nb and Ti to form the（ Nb,Ti,Mo） C carbides.展开更多
文摘Objective:To explore the changes of immune function and serum inflammatory cytokines levels in patients with primary biliary cirrhosis.Methods: Fifty-five patients with primary biliary cirrhosis who were treated in our hospital from June 2015 to January 2017 were selected as the observation group and 55 healthy subjects were selected as the control group. The liver function, immune function and inflammatory cytokines levels were measured.Results: The levels of ALT, AST and TBIL in observation group were (103.2±6.14) U/L, (96.07±3.48) U/L and (86.60±8.25)μmol/L respectively, which were significantly higher than those in control group, the difference was statistically significant;The levels of IL-6, IL-8, IL-10 and TNF-αin the observation group were (68.47±10.70) pg/mL, (881.49±94.50) pg/mL, (50.49±5.22) pg/mL and (429.45±96.13) pg/mL, which were significantly higher than those in healthy controls;The percentage of CD3+, CD4+, CD8+ and CD4+/CD8+ in the observation group were (68.73±7.21)%, (42.31±1.06)%, (20.27±1.1)% and (2.35±0.08)%, and the CD3+, CD4+, CD4+/CD8+ levels were obviously higher than control group. There was no significant difference in CD8+ level compared with control group.Conclusion: Patients with primary biliary cirrhosis have abnormal liver function, immune dysfunction and inflammatory response, which should be timely monitored in clinical treatment so as to treat the disease more effectively.
基金Item Sponsored by High Technology Research and Development Program of China(2012AA03A508)
文摘A study on ultrahigh strength steel plate subjected to novel thermo-mechanical control process was presented. The mechanical properties examination showed that the investigated steel exhibited excellent combination of ultra-high strength（ 2 200 MPa） and toughness（ 26 J）. The microstructure of the experimental steel was observed by scanning electron microscope and transmission electron microscope. Desired martensitic lath with width of about 180- 250 nm was obtained. Nanostructured carbide precipitates with sizes of 20-50 nm,which contained Nb,Ti and Mo,were observed in the lath martensitic microstructure,and confirmed to be MC-type carbides with B1 structure by means of selected area electron diffraction.The compositional characteristics revealed by energy dispersive X-ray spectrometer mapping implied that the carbide forming elements Nb,Ti and Mo distributed in the precipitates evenly. Three-dimensional atom probe tomography reconstruction further indicated that Mo incorporated into the precipitates without enrichment in the carbide-matrix interface and probably substituted for Nb and Ti to form the（ Nb,Ti,Mo） C carbides.
