精密轴承用PEEK保持架结构及注塑工艺优化

针对原PEEK保持架兜孔无锁口,采用侧向抽芯机构进行注塑加工时外圆精度低的问题,将保持架兜孔分成内外两部分且设计为球面,注塑模具采用单分型面注塑模结构。并对注塑工艺浇口结构和浇口数量进行优化,基于正交试验得到最优工艺参数为模具温度180℃、熔体温度390℃、保压时间5 s和保压压力55 MPa。实际加工表明:外径面圆度不大于0.15 mm占86%;拉伸强度远高于65 MPa;200℃高温摩擦系数平均值为0.195,磨痕宽度平均值为0.9625 mm,磨损量平均值为0.1394 mm^(3);与相应公差等级套圈、球合套后,轴承旋转精度达到P4,振动值达到Z4。

Interface Migration between Martensite and Austenite during Quenching and Partitioning (Q&P) Process

Fe-0.2C-l.5Si-l.67Mn 钢受到熄灭并且划分(Q&P ) 进程，和在在提高的划分温度的马氏体和奥氏体之间的接口移植被观察。接口迁居在 constrainedparaequilibrium (用户终端设备) 被排除模型。基于“端点”由用户终端设备模型预言接口移植的热力学的条件被分析，也就是说，在在铁酸盐(martenisite ) 和奥氏体的铁的化学势的差别生产铁原子的驱动力从一个阶段移居到另外的阶段。另外，接口迁居罐头改变奥氏体部分；作为结果，在划分温度的奥氏体部分可能在通过接口移植熄灭温度比那高，但是这现象不能被用户终端设备模型解释。

全产业链模式下国内农产品供应链韧性提升的路径研究——以郑明物流与建发股份的冷链合作为案例分析

加强农产品供应链的韧性,有助于实现全国保障物流畅通,对国内的产业链大循环起到托底作用。文章基于全产业链理论,对国内农产品供应链中的堵点、断点进行系统性梳理,并对强链、补链的路径进行了分析,基于分析结论,结合郑明物流与建发股份的冷链合作案例,对提升国内农产品供应链韧性的具体举措进行研究。结果表明,加强冷链农产品供应链的数字化建设,提升对农产品供应链上各节点的普惠金融支持力度,加大农产品期货衍生品的开发力度,有助于农产品供应链的强链与补链。在此基础上,提出了当前市场要素配置下提升农产品供应链韧性的对策建议。

我国“十四五”科技创新战略研究与启示——基于人民网新闻数据

[目的/意义]准确把握科技创新战略能够为政府工作人员、科学研究人员和企业管理人员准确理解国家战略发展目标提供决策支持。[方法/过程]构建了基于新闻数据的科技创新战略主题多维度分析框架,从人民网数据库中采集“十四五”规划实施前后发布的科技创新战略相关新闻,在主题发现的基础上,通过主题强度、主题态势和战略坐标图多个维度对比“十四五”规划实施前后科技创新战略的变化特征。[结果/结论]高质量科技创新人才、科技创新重点规划等主题是“十四五”规划科技创新战略中的核心,高新技术人才政策是相对独立的主题,对科技创新战略具有重要的支持作用,规划实施后更加关注科技创新人才与人才教育。研究结论为政府、科研单位和企业接下来的工作重点提供了方向和思路。

基于PVAR模型的科技创新、国际技术溢出与数字经济增长关系实证分析——以粤港澳大湾区为例

为探究科技创新,国际技术溢出与数字经济增长三者之间相互影响与作用机制,以科技创新,国际技术溢出与数字经济增长的作用机制为理论基础提出假设,利用2006—2021年广东省珠三角九市的相关数据描述区域整体情况,构建面板向量自回归PVAR模型、Fisher检验、Kao协整关系检验和脉冲响应函数等进行实证分析。结果表明,科技创新对国际技术溢出和数字经济增长具有促进作用,数字经济增长和国际技术溢出对科技创新具有明显的正向作用,而国际技术溢出和数字经济之间存在一定相互抑制作用。为此,政府应推行“双化”协同综合试点创建战略,利用数字要素生产禀赋差异促进区域间产业结构合理化,以国际技术溢出扩散效应带动数字经济高质量发展和科技创新。

苗药九仙罗汉接骨汤含药血清对MC3T3-E1Subclone14细胞增殖、凋亡和Runx2、Osterix、Bax、Bcl-2表达的影响

目的:观察苗药九仙罗汉接骨汤含药血清对MC3T3-E1Subclone14细胞增殖、凋亡及Runx2、Osterix、Bax、Bcl-2 mRNA及蛋白表达的影响,探讨其促进成骨细胞增殖,抑制成骨细胞凋亡的可能机制。方法:将体外培养的MC3T3-E1Subclone14细胞系分为空白对照组、仙灵骨葆胶囊组及九仙罗汉接骨汤含药血清低、中、高浓度组,各组制备含药血清后均用高糖DMEM培养液分别配制成不同浓度进行培养;培养24 h后采用MTT与流式细胞仪检测细胞增殖及凋亡;RT-PCR与Western Blot、免疫组化法测定Runx2、Osterix、Bax、Bcl-2 mRNA及蛋白表达。结果:与空白对照组比较,九仙罗汉接骨汤含药血清中、高浓度组增殖能力显著升高,细胞凋亡率显著降低,Runx2、Osterix、Bcl-2 mRNA及蛋白表达显著升高,Bax mRNA及蛋白表达显著降低(P<0.05或P<0.01)。结论:苗药九仙罗汉接骨汤可促进MC3T3-E1Subclone14细胞增殖,并抑制其凋亡,其作用机制可能与调节Runx2、Osterix、Bax、Bcl-2基因及蛋白表达有关。

异构多核计算系统的Codelet任务调度策略

Codelet数据流计算模型在处理大规模并行计算任务时效果显著,但该模型目前缺少在异构多核环境中的任务调度策略。因此,提出了一种在异构多核环境下基于蚁群算法的Codelet任务调度策略。该调度策略将启发式算法与蚁群算法相融合,在发挥各自优势的同时克服了启发式算法不能得出最优解的缺陷以及蚁群算法初始信息匮乏的问题。实验结果表明,智能蚁群任务调度策略相比Codelet运行时系统中原生的动态调度和静态调度策略具有更高的执行效率。

注塑轴承保持架圆度分析及控制方法

通过对注塑轴承保持架材料、结构及成型模具结构、精度和注塑工艺等方面进行分析与探讨,提出解决注塑保持架圆度的控制方法。

新疆SETH水利枢纽砂石骨料加工系统的升级与改良

介绍了对新疆SETH水利枢纽工程砂石加工系统生产能力、产量、级配、除尘进行的升级改良过程,升级改良后,骨料供应满足工程建设的需求量和级配要求,除尘效果明显,减少了扬尘,环境得到了很大程度地提升。介绍了具体的砂石骨料加工系统的升级与改良过程。

颠覆性技术研究述评与展望——基于战略生态位管理视角

颠覆性技术突破了传统技术的发展轨迹,推动新产业、新业态、新模式的加速迭代。战略生态位管理是新兴管理理论,能够对颠覆性技术的整个发展轨迹进行高效管理,推动颠覆性技术从技术生态位“跃迁”至市场生态位,并最终到达范式生态位,从而颠覆主流技术,带来深刻的社会技术变革。文章辨析了颠覆性技术的概念内涵,以战略生态位管理视角,阐释颠覆性技术的研究与应用,为未来的研究方向提供了建议与展望。

社会性创业企业的双底线绩效评价

和谐社会建设的目标之一就是促进公共服务的发展。然而,政府不是万能的,公共服务不能完全靠政府提供,要通过社会组织来完成一些公共职能。非营利组织由于其自身资金来源的问题而不能完全满足社会对公共服务的要求,而欧美近年出现的"社会性创业"结合了营利组织和非营利组织的特点,可以更好地完成这一任务。本文介绍了社会性创业的起源和含义,社会性创业企业评价的目标,描述了在双底线绩效评价原则下的三种现行方法和双底线绩效评价应用实例,并提出在绩效评估中需要注意的问题。

Comprehensive Design of the High-Sulfur-Loading Li–S Battery Based on MXene Nanosheets

The lithium-sulfur battery is the subject of much recent attention due to the high theoretical energy density,but practical applications are challenged by fast decay owing to polysulfide shuttle and electrode architecture degradation.A comprehensive study of the sulfur host microstructure design and the cell architecture construction based on the MXene phase(Ti3C2Tx nanosheets) is performed,aiming at realize stable cycling performance of Li-S battery with high sulfur areal loading.The interwoven KB@Ti3C2Tx composite formed by self-assembly of MXene and Ktej en black,not only provides superior conductivity and maintains the electrode integrality bearing the volume expansion/shrinkage when used as the sulfur host,but also functions as an interlayer on separator to further retard the polysulfide cross-diffusion that possibly escaped from the cathode.The KB@Ti3C2Tx interlayer is only 0.28 mg cm-2 in areal loading and 3 μm in thickness,which accounts a little contribution to the thick sulfur electrode;thus,the impacts on the energy density is minimal.By coupling the robust KB@Ti3C2Tx cathode and the effective KB@Ti3C2Tx modified separator,a stable Li-S battery with high sulfur areal loading(5.6 mg cm-2) and high areal capacity(6.4 mAh cm-2) at relatively lean electrolyte is achieved.

How to Make "Web Intelligence (WI) Meets Brain Informatics (BI)" Successfully﹖

Recently, we gave a new perspective of Web Intelligence (WI) research from the viewpoint of Brain Informatics (BI), a new interdisciplinary field that studies the mechanisms of human information processing from both the macro and micro viewpoints by combining experimental cognitive neuroscience with advanced information technology.We argue that new instruments like fMRI and information technology will revolutionize both Web intelligence and brain science. This revolution will be bi-directional: new understanding of human intelligence through brain science will yield a new generation of Web intelligence research and development, and Web intelligence portal techniques will provide a powerful new platform for brain science. The ultimate goal is to establish the foundation of WI towards human-level Web intelligence. In this talk, we investigate how to make such a study successfully.

积石山Ms 6.2级地震诱发的次生泥流灾害再现喇家遗址史前灾难场景

喇家遗址位于青海省民和县官亭盆地黄河北岸的第二级阶地之上,是一处以大型的齐家文化(4200~3600 a BP)为主的聚落遗址[1].在遗址区8处房址中发现了32具非正常死亡人骨遗骸和惨烈灾难场景,被称为“东方庞贝”,并出土了已知世界上最早的面条.凭借其罕见的史前灾难遗迹和诸多突破性的新发现,喇家遗址入选2001年度“全国十大考古新发现”[1~4].近年来,对于造成喇家遗址齐家文化时期人群突然死亡和聚落毁灭废弃的灾难问题,学术界提出了各种观点和见解,引发了激烈的学术争议[4~9].其中,基于观察到的史前地震现象、毁灭喇家遗址齐家文化聚落的堆积物、全新世地层沉积特征和区域地貌演化,学术界提出了3种不同的观点.

De novo ADGRV1 variant in a patient with ictal asystole provides novel clues for increased risk of SUDEP

Background Various cardiac and autonomic manifestations are frequently reported during seizures.Among the seizure-related arrhythmia,ictal tachycardia is the most common,followed by ictal bradycardia,with ictal asystole being the rarest.The occurrence of ictal asystole may obscure the clinical presentation and delay the diagnosis,representing a life-threatening presentation of epilepsy,with an elevated risk of sudden unexpected death in epilepsy patients(SUDEP).These cardiac abnormalities are being increasingly recognized as the key to elucidating the mechanisms of SUDEP.Case presentation We present a 35-year-old man with a history of focal-onset seizures with impaired consciousness since his mid-20 s.He developed different types of seizures for 2 years,described as tonic seizure and atonic seizure(drop attack).During such clinical events,he suffered from falls and cardiac arrest.However,thorough cardiac electrophysiology and imaging workup failed to reveal a cardiac etiology.Subsequent video electroencephalograph(EEG)monitoring was performed,and ictal bradycardia and ictal asystole were discovered.A cardiac pacemaker was implanted,and at 3-year follow-up,the patient did not suffer more atonic seizures,or falls.Genetic tests discovered a de novo variant of Adhesion G Protein-Coupled Receptor V1(ADGRV1),which may provide a clue for the patient’s ictal asystole and the increased risk of SUDEP.Conclusions Considering the important impact of ictal bradycardia and asystole on the morbidity and potential mortality of epileptic patients,it is important to simultaneously utilize EEG and electrocardiogram to confirm the diagnosis.This case report highlights the link between the de novo variant of ADGRV1 and the ictal bradycardia/asystole phenotype and implicates the importance of genetic testing in adult epilepsy patients.

Heterogeneity of clinical features, EEG and brain imaging findings in anti‑leucine‑rich glioma‑inactivated protein 1 autoimmune encephalitis: a retrospective case series study and review of the literature

Background Anti-leucine-rich glioma-inactivated 1(LGI-1)autoimmune encephalitis(AE),characterized by rapid decline of memory,seizures,and neuropsychiatric abnormalities,is a rare but devastating disorder.Early diagnosis and treatment are essential to prevent long-term sequelae.In this report,we provide a detailed description of clinical characteristics,laboratory test results,imaging,and electroencephalography(EEG)findings,as well as treatment responses of eight patients with anti-LGI-1 AE treated at our center.Case presentation At the onset,all eight patients presented with confusion/memory deterioration,seizures(including faciobrachial dystonic seizures or other types of seizure),and behavioral changes such as hallucination,paranoia,and anxiety.Four patients were found with severe hyponatremia.Anti-LGI1 antibodies were detected in the cerebrospinal fluid and/or serum of all patients.For patients with faciobrachial dystonic seizures,no discernible scalp EEG change was detected,while EEG recording of patients experiencing other types of seizure showed focal slowing,focal epileptiform discharges,and focal onset seizures.All patients showed abnormal brain magnetic resonance imaging signals,mainly involving the mesial temporal lobe and the hippocampus.In addition,one patient also experienced fulminant cerebral edema during the acute phase of the illness.All patients received immunotherapy and anti-seizure medications and achieved good seizure control.Nevertheless,these patients continued to experience cognitive impairment during their long-term follow-ups.Conclusions The care of anti-LGI1 AE patients requires rapid evaluation,prompt initiation of immunotherapy,and long-term follow-up.The long-term presence of neurocognitive complications observed in these patients underline the importance of developing reliable biomarkers that can distinguish between different subtypes of this disease with heterogeneous clinico-electrographico-radiological features.Further research is needed to understand the molecular mechanisms underlying the heterogeneity,in order to facilitate development of more effective treatments for anti-LGI1 AE.

Outcomes of endoscopic sclerotherapy for jejunal varices at the site of choledochojejunostomy (with video): Three case reports

BACKGROUND Hemorrhage associated with varices at the site of choledochojejunostomy is an unusual,difficult to treat,and often fatal manifestation of portal hypertension.So far,no treatment guidelines have been established.CASE SUMMARY We reported three patients with jejunal varices at the site of choledochojejun-ostomy managed by endoscopic sclerotherapy with lauromacrogol/α-butyl cyanoacrylate injection at our institution between June 2021 and August 2023.We reviewed all patient records,clinical presentation,endoscopic findings and treatment,outcomes and follow-up.Three patients who underwent pancre-aticoduodenectomy with a Whipple anastomosis were examined using conven-tional upper gastrointestinal endoscopy for suspected hemorrhage from the afferent jejunal loop.Varices with stigmata of recent hemorrhage or active he-morrhage were observed around the choledochojejunostomy site in all three patients.Endoscopic injection of lauromacrogol/α-butyl cyanoacrylate was carried out at jejunal varices for all three patients.The bleeding ceased and patency was observed for 26 and 2 months in two patients.In one patient with multiorgan failure and internal environment disturbance,rebleeding occurred 1 month after endoscopic sclerotherapy,and despite a second endoscopic sclero-therapy,repeated episodes of bleeding and multiorgan failure resulted in eventual death.CONCLUSION We conclude that endoscopic sclerotherapy with lauromacrogol/α-butyl cyanoac-rylate injection can be an easy,effective,safe and low-cost treatment option for jejunal varicose bleeding at the site of choledochojejunostomy.

Effects of proton pump inhibitor on gastroesophageal varices in patients with cirrhosis:A randomized controlled trial from China

Aims:Proton pump inhibitors(PPI)are widely used for gastroesophageal varices in patients with cirrhosis after endoscopic therapy,although the effect of PPI on these patients remains controversial.This study aimed to evaluate the effect of PPI on gastroesophageal varices in patients with cirrhosis after endoscopic therapy,including variceal bleeding and adverse events.Methods:Cirrhotic patients with endoscopically confirmed gastroesophageal varices were enrolled in this study between May 2017 and June 2019.Eligible patients were randomized into two groups:one group received PPI for 14 days and the other group did not receive PPI treatment(n=53 in each group).All patients were followed for 8 weeks.Results:During the follow‐up period,three patients(5.66%)in the PPI group experienced variceal bleeding on days 9,16,and 25 after endoscopic therapy,including two patients with acute bleeding and one with primary prophylaxis.In the non‐PPI group,three patients(5.66%)experienced variceal bleeding on days 7,42,and 56 after endoscopic therapy,including one patient with acute bleeding and two with secondary prophylaxis(p=0.990).The incidence of adverse events was similar between the two groups(37.74%vs.28.30%,p=0.30).Conclusions:PPI did not appear to reduce variceal bleeding and adverse events in patients with cirrhosis after endoscopic therapy.

KMG:考虑逆向物流的无人机路径规划策略研究

物流领域无人机派送正成为一种快捷高效的派件方式和应用热点.针对于正向、逆向的物流数据,无人机派送是国内外大型物流企业实施高效物流派送的重要手段.本文提出了一种融合拓展性K-Means++算法和遗传算法的路径动态规划模型(KMG),实现包含逆向物流的无人机调度策略.KMG模型将逆向物流路径融入正向物流路径之中,采用加权聚类算法确定不同属性包裹所需派送无人机的最小数量.在每一簇坐标数据的连通图中,采用遗传算法求解TSP问题,并对可行解进行编码,最终求解出最小欧拉回路.在仿真实验中,KMG模型比独立逆向物流派送的成本减少20.08%,使用拓展性K-Means++聚类计算的时间比传统K-Means算法缩短了298.85%.

基于专利和Bass模型的颠覆性技术识别方法研究

文章对现有颠覆性技术及其识别方法的研究进行了梳理,构建了一种采用专利引用信息和Bass模型对颠覆性技术进行识别和判断的新方法,并利用1976-2016年间的445条美国专利数据对太阳能光伏发电技术进行了实证分析,结果验证了薄膜电池发电是一项颠覆性技术,其技术扩散呈现典型的S型轨迹,并将在未来40年进入技术快速扩散期。本方法能够在早期对颠覆性技术进行识别,为研究人员和管理者提供决策依据和参考。